姓名：王悦冰

职称：副教授

一、教育经历

2005.09–2008.07中国农业科学院，生物化学与分子生物学，理学博士

二、工作经历

2016至今南开大学，医学院，副教授

2008.07–2015.12南开大学，医学院，讲师

2016.12–2018.1斯坦福大学，医学院，访问学者

三、研究方向

分子影像学，干细胞生物学，肿瘤生物学

主持或参加科研项目

1.       国家自然科学基金面上项目，81971670，基于多模态分子影像学研究细胞外囊泡治疗急性肾损伤机制，2020.1–2023.12，主持

2.       中国科协创新战略研究院科研项目，2019-pgs-002，老科技工作者健康养老问题与对策研究，2020.1–2023.12，主持

3.       中国人民解放军总医院肾脏疾病国家重点实验室开放课题基金，KF-2018-04，聚集诱导发光材料示踪间充质干细胞来源的细胞外囊泡修复缺血再灌注肾损伤，2018.12–2020.12，主持

4.       国家重点研发计划重点专项，2020YFA0803700，三维智能生物材料构建血管化胰岛类器官及其代谢与转化应用，2020.12-2025.11，主要科研骨干

5.       军队后勤科研项目，BLB21J008，创伤组织缺损替代材料应用研究，2021.6-2024.12，主要科研骨干

6.       国家重点研发计划，2017YFA0103201，不同胚层组织器官损伤后细胞应答及再生细胞活化因子的筛选，2017.07–2021.12，科研骨干

7.       国家留学基金委国家公派访问学者项目，2016.12-2017.12

8.       国家自然科学基金青年基金项目，81501528，TNF-α预激活的人脐带间充质干细胞靶向治疗乳腺癌的分子影像学研究，2016.01–2018.12，主持

9.       国家自然科学基金面上项目，21577070，环境因子重塑痕量氧化石墨烯诱发的生物跨代效应及其分子途径研究，2016.01–2019.12，参加

10.    天津市科技计划应用基础与前沿技术研究计划项目，15JCQNJC10600，人脐带间充质干细胞靶向治疗乳腺癌的分子影像学研究，2015.04–2018.03，主持

11.    国家重点基础研究发展计划，2011CB94400，肾血管球形成和足细胞发育的分子调控机制，2011.01–2015.08，科研骨干

12.    高等学校基本科研业务费，Z1A2204954，人类血管平滑肌细胞相关小分子RNA的功能及利用研究，2010.09–2013.09，主持

四、学术兼职

天津市医学影像技术研究会，基础医学影像分会，常委

中国生物医学工程学会，类器官与器官芯片分会，委员

中国光学学会，第三届生物医学光子学专委会，委员

中国细胞生物学学会，干细胞生物学分会，委员

五、发表文章

第一作者或通讯作者

1.    Cao, H.^#;  Gao, H.^#;  Wang, L.;  Cheng, Y.;  Wu, X.;  Shen, X.;  Wang, H.;  Wang, Z.;  Zhan, P.;  Liu, J.;  Li, Z.;  Kong, D.;  Shi, Y.;  Ding, D.; Wang, Y.*, Biosynthetic Dendritic Cell-Exocytosed Aggregation-Induced Emission Nanoparticles for Synergistic Photodynamic Immunotherapy. ACS nano 2022.

2.    Cheng, Y.^#;  Yue, Y.^#;  Cao, H.^#;  Geng, W.;  Wang, L.;  Hu, X.;  Li, H.;  Bian, Q.;  Kong, X.;  Liu, J.;  Kong, D.;  Guo, D.*; Wang, Y.*, Coassembly of hypoxia-sensitive macrocyclic amphiphiles and extracellular vesicles for targeted kidney injury imaging and therapy. J Nanobiotechnology 2021,19 (1), 451.

3.   Cao, H.^#;  Cheng, Y.^#;  Gao, H.;  Zhuang, J.;  Zhang, W.;  Bian, Q.;  Wang, F.;  Du, Y.;  Li, Z.;  Kong, D.;  Ding, D.*; Wang, Y.*, In Vivo Tracking of Mesenchymal Stem Cell-Derived Extracellular Vesicles Improving Mitochondrial Function in Renal Ischemia-Reperfusion Injury. ACS nano 2020,14 (4), 4014-4026.

4.    Huang, A.^#;  Liu, D.^#;  Qi, X.*;  Yue, Z.;  Cao, H.;  Zhang, K.;  Lei, X.;  Wang, Y.;  Kong, D.;  Gao, J.;  Li, Z.;  Liu, N.*; Wang, Y.*, Self-assembled GFFYK peptide hydrogel enhances the therapeutic efficacy of mesenchymal stem cells in a mouse hindlimb ischemia model. Acta Biomater 2019,85, 94-105.

5.    Cao, H.^#;  Yue, Z.^#;  Gao, H.;  Chen, C.;  Cui, K.;  Zhang, K.;  Cheng, Y.;  Shao, G.;  Kong, D.;  Li, Z.*;  Ding, D.*; Wang, Y.*, In Vivo Real-Time Imaging of Extracellular Vesicles in Liver Regeneration via Aggregation-Induced Emission Luminogens. ACS nano 2019,13 (3), 3522-3533.

6.    Wang, Y.^#;  Shao, G.^#;  Wu, J.;  Cui, C.;  Zang, S.;  Qiu, F.;  Jia, R.;  Wang, Z.*; Wang, F.*, Preparation of (68)Ga-PSMA-11 with a Synthesis Module for Micro PET-CT Imaging of PSMA Expression during Prostate Cancer Progression. Contrast Media Mol Imaging 2018,2018, 8046541.

7.    Wang, Y.*;  Cheng, Z.;  Liu, S.; Shao, G.*, Molecular Imaging in Targeted Therapeutics. Contrast Media Mol Imaging 2018,2018, 3236829.

8.    Shao, G.^#;  Wang, Y.^#;  Liu, X.;  Zhao, M.;  Song, J.;  Huang, P.;  Wang, F.*; Wang, Z.*, Investigation of Newly Prepared Biodegradable (32)P-chromic Phosphate-polylactide-co-glycolide Seeds and Their Therapeutic Response Evaluation for Glioma Brachytherapy. Contrast Media Mol Imaging 2018,2018, 2630480.

9.    Li, M. ^#;  Xu, L. ^#;  Feng, G.;  Zhang, Y.;  Wang, X.; Wang, Y.*. High glucose downregulates myocardin expression in rat glomerular mesangial cells via the ERK signaling pathway Oncotarget [Online], 2017, p. 87390-87400.

10.  Wang, Y.;  Feng, G.;  Wang, J.;  Zhou, Y.;  Liu, Y.;  Shi, Y.;  Zhu, Y.;  Lin, W.;  Xu, Y.; Li, Z.*, Differential effects of tumor necrosis factor-alpha on matrix metalloproteinase-2 expression in human myometrial and uterine leiomyoma smooth muscle cells. Hum Reprod 2015,30 (1), 61-70.

11.  Zhou, Y.;  Ren, Y.;  Cui, L.;  Li, Z.;  Zhu, Y.;  Lin, W.; Wang, Y.*, Differential expression of caveolin-1 in human myometrial and uterine leiomyoma smooth muscle. Am J Obstet Gynecol 2014,211 (5), 496 e1-496 e13.

12.  Wang, Y. ;  Li, M.;  Xu, Y.;  He, N.;  Leng, L.; Li, Z.*, Tumor necrosis factor-alpha regulates matrix metalloproteinase-2 expression and cell migration via ERK pathway in rat glomerular mesangial cells. Cell Biol Int 2014,38 (9), 1060-8.

13.  Leng, L.^#;  Wang, Y.^#;  He, N.;  Wang, D.;  Zhao, Q.;  Feng, G.;  Su, W.;  Xu, Y.;  Han, Z.;  Kong, D.;  Cheng, Z.;  Xiang, R.; Li, Z.*, Molecular imaging for assessment of mesenchymal stem cells mediated breast cancer therapy. Biomaterials 2014,35 (19), 5162-70.

14. Wang Y., Li Z. Traceable Therapeutic Strategy for Treatment of Breast Cancer with Mesenchymal Stem Cells (MSCs). Cancer cell & microenvironment. 2014, 1,125-128. (invited review)

非第一作者或通讯作者

1. Chen, H.; Yang, H.; Zhang, C.; Chen, S.; Zhao, X.; Zhu, M.; Wang, Z.; Wang, Y.; Wo, H. T.; Li, K.; Cheng, Z., Differential Responses of Transplanted Stem Cells to Diseased Environment Unveiled by a Molecular NIR-II Cell Tracker. Research 2021, 2021, 9798580.

2. Chen, H.; Shou, K.; Chen, S.; Qu, C.; Wang, Z.; Jiang, L.; Zhu, M.; Ding, B.; Qian, K.; Ji, A.; Lou, H.; Tong, L.; Hsu, A.; Wang, Y.; Felsher, D. W.; Hu, Z.; Tian, J.;Cheng, Z., Smart Self-Assembly Amphiphilic Cyclopeptide-Dye for Near-Infrared Window-II Imaging. Adv Mater 2021, 33 (16), e2006902.

3. Zhang, Y.; Wang, D.; Xu, J.;Wang, Y.; Ma, F.; Li, Z.; Liu, N. Stat3 activation is critical for pluripotency maintenance. J Cell Physiol. 2019, 234, 1044-1051.

4. Sang, H.; Wang, D.; Zhao, S.; Zhang, J.; Zhang, Y.; Xu, J.; Chen, X.; Nie, Y.; Zhang, K.; Zhang, S.;Wang, Y.; Wang, N.; Ma, F.; Shuai, L.; Li, Z.; Liu, N. Dppa3 is critical for Lin28a-regulated ES cells naiveprimed state conversion. J Mol Cell Biol. 2019, 11(6), 474-488.

5. Zhang, K.; Zhao, X.; Chen, X.; Wei, Y.; Du, W.;Wang, Y.; Liu, L.; Zhao, W.; Han, Z.; Kong, D.; Zhao, Q.; Guo, Z.; Liu, N.; Ma, F.; Li, Z. Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018, 10, 30081-30091.

6. Wang, R.; Zhang, K.; Tao, H.; Du, W.; Wang, D.; Huang, Z.; Zhou, M.; Xu, Y.;Wang, Y.; Liu, N.; Wang, H.; Li, Z. Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence. Curr Pharm Biotechnol. 2017, 18, 422-428.

7. Wang, D.; Sang, H.; Zhang, K.; Nie, Y.; Zhao, S.; Zhang, Y.; He, N.;Wang, Y.; Xu, Y.; Xie, X.; Li, Z.; Liu, N. Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media. Oncotarget. 2017, 8, 31227-31237.

8. He, N.; Feng, G.; Li, Y.; Xu, Y.; Xie, X.; Wang, H.;Wang, Y.; Ou, L.; Pei, X.; Liu, N.; Li, Z. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7, 95.

9. He, N.; Xu, Y.; Du, W.; Qi, X.; Liang, L.;Wang, Y.; Feng, G.; Fan, Y.; Han, Z.; Kong, D.; Cheng, Z.; Wu, J. C.; He, Z.; Li, Z. Extracellular Matrix can Recover the Downregulation of Adhesion Molecules after Cell Detachment and Enhance Endothelial Cell Engraftment. Sci Rep. 2015, 5, 10902.

10. Zhao, Q.; Tong, L.; He, N.; Feng, G.; Leng, L.; Sun, W.; Xu, Y.;Wang, Y.; Xiang, R.; Li, Z. IFN-gamma mediates graft-versus-breast cancer effects via enhancing cytotoxic T lymphocyte activity. Exp Ther Med. 2014, 8, 347-354.

11. Wang, L.;Wang, Y.; Li, Z. Nanoparticle-based tumor theranostics with molecular imaging. Curr Pharm Biotechnol. 2013, 14, 683-692.

12. Tian, R.; Wang, Z.; Shi, Z.; Li, D.;Wang, Y.; Zhu, Y.; Lin, W.; Gui, Y.; Zheng, X. L. Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. Fertil Steril. 2013, 99, 256-263.

13. Feng, G.; Mao, D.; Che, Y.; Su, W.;Wang, Y.; Xu, Y.; Fan, Y.; Zhao, H.; Kong, D.; Li, Z. The phenotypic fate of bone marrow-derived stem cells in acute kidney injury. Cell Physiol Biochem. 2013, 32, 1517-1527.

14. Li, J.; Jiang, J.; Yin, H.; Wang, L.; Tian, R.; Li, H.; Wang, Z.; Li, D.; Wang, Y.; Gui, Y.; Walsh, M. P.; Zheng, X. L. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension. 2012, 60, 145-153.

15. Li, H.; Li, J.; Li, Y.; Singh, P.; Cao, L.; Xu, L. J.; Li, D.; Wang, Y.; Xie, Z.; Gui, Y.; Zheng, X. L. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2012, 303, H1319-1331.

六、讲授课程

1.       生物化学

2.       综合生物学实验3-2

3.       Biochemistry

4.       Comprehensive biology experiment 3-2

七、荣誉和奖励

1.       2022年大学生创新科研奖三等奖指导教师

2.       2020年优秀硕士论文指导教师

3.       2016年国家公派访问学者奖

4.       2015年大学生创新科研校三等奖指导教师

5.       2014-2015年度南开大学口腔医院优秀教师奖教金二等奖

6.       2012南开大学实验教学技术成果二等奖

八、联系方式

通讯地址：天津市南开区卫津路94号

Email：wangyuebing@nankai.edu.cn