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中国人民解放军总医院
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李娜

姓名: 李 娜
职称: 副教授

一、教育经历
2002.9-2008.5 美国Rutgers & University of Medicine and Dentistry of New Jersey, 生理与整合生物专业,博士学位
1993.9-1998.6 河南医科大学妇幼专业,医学学士学位

二、工作经历
2011-至今 南开大学医学院,副教授
2008-2011 南开大学医学院,讲师

三、研究方向
(一)研究领域:
1. 探索肿瘤的抗凋亡、耐药复发及转移的相关分子机制;
2. 探索肿瘤干细胞与肿瘤微环境之间相互作用的分子机制;
3. 肿瘤的靶向治疗;
4. 结合DNA疫苗与细胞因子辅助的方法来制定新型的肿瘤治疗策略。
(二)主持的科研课题:
1. 国家自然科学基金面上项目 “肿瘤干细胞重塑微环境调控新生血管生成的研究”,起止日期 2016.1-2019.12,项目负责人
2. 国家自然科学基金面上项目 “SOX2对IL6R转录调控在肿瘤转移中作用的研究”,起止日期 2014.1-2017.12,项目负责人
3. 教育部留学回国人员科研启动经费“SOX2在肿瘤转移中作用的研究”,起止日期 2012.1-2014.12,项目负责人
4. 国家自然科学基金青年基金“SOX2在肿瘤细胞耐药抗凋亡特性中作用的研究”,起止日期 2011.1-2013.12,项目负责人
5. 中央高校基本科研业务费专项资金“SOX2在与肿瘤转移相关EMT过程中作用的研究”,起止日期 2010.6-2012.5,项目负责人
6. 教育部高等学校博士学科点专项科研基金“Ca2+-Calcineurin/NFAT信号通路在前列腺癌干细胞中作用的研究”,起止日期 2010.1-2012.12,项目负责人
7. 国家国际科技合作与交流专项基金“新型乳腺癌早期预警系统的建立及防治方法的合作研究”,起止日期 2012.06-2015.05,主要参与人
8. 国家科技重大专项项目: CSCs的分离、识别及其分子遗传特征 起止日期:2013.3-2016.8,子课题学术骨干
9. 天津市科委中瑞合作重点项目“肿瘤转移的分子机制及临床应用研究”,起止日期2009.10-2012.09,主要参与人

四、学术兼职
1.2015-至今 天津市免疫学会 会员
2.2011-至今 美国肿瘤研究协会(AACR) 会员
3.2010-至今 中国抗癌协会 会员
4. 2005-2008 美国生物物理学会(Biophysics Society)会员

五、近5年论文
1. S Zhao, N Bai, J Cui, R Xiang*and Na Li* Prediction of Survival of Diffuse-Large-B-Cell Lymphoma patients via the Expression of Three Inflammatory Genes. Cancer medicine 2016 Aug;5(8):1950-61. *Corresponding author
2. Y Xu, S Zhang, H Niu, Y Ye, F Hu, S Chen, X Li, Y Liu, Y Chen, J Li, R Xiang and Na Li*. STIM1 inhibits tumor growth but promotes the metastasis of prostate cancer by remodeling tumor microenvironment and enhancing epithelial-to-mesenchymal transition. Scientific Reports 2015 Aug 10;5:11754. *Corresponding author
3. Y Xu, R Liao, Na Li, R Xiang, P Sun. Phosphorylation of Tip60 by p38α regulates p53-mediated PUMA induction and apoptosis in response to DNA damage. Oncotarget. 2014 Dec 30;5(24):12555-72.
4. W Mou, Y Xu, Y Ye, S Chen, K Gong, Y Chen, Y Liu, X Li, Y Tian, R Xiang and Na Li Expression of Sox2 in breast cancer cells promotes the recruitment of M2 macrophage to tumor microenvironment. Cancer Letters 2015 Mar 28;358(2):115-23. *Corresponding author
5. W Su, S Chen, Na Li*. The potential role of SOX2 in the anti-apoptosis property of cancer cells. Cancer Cell & Microenvironment 2014; 1: e253. *Corresponding author
6. Y Xu, Na Li, R Xiang, P Sun. Emerging roles of the p38 MAPK and PI3K/AKT/mTOR pathways in oncogene-induced senescence. Trends in biochemical sciences 2014 Jun;39(6):268-76.
7. S Chen, X Li, D Lu, Y Xu, W Mou, L Wang, Y Chen, Y Liu, X Li, LY Li, L Liu, D Stupack, RA Reisfeld, R Xiang* and Na Li*. SOX2 regulates apoptosis through MAP4K4-Survivin signaling pathway in human lung cancer cells. Carcinogenesis 2014 Mar;35(3):613-23. *Corresponding author
8. X Li, S Chen, T Sun, Y Xu, Y Chen, Y Liu, R Xiang and Na Li*The negative regulation effect of SOX2 on FOXA1 gene expression and its application in the diagnosis of human breast and lung cancers. Clinical Laboratory 2014; 60(6):909-18. *Corresponding author
9. J Yang, Z Zhang, C Chen, Y Liu, Q Si, T-H Chuang, Na Li, A Gomez-Cabrero, RA Reisfeld, R Xiang and Y Luo. MicroRNA-19a-3p inhibits breast cancer progression and metastasis by inducing macrophage polarization through downregulated expression of Fra-1 proto-oncogene. Oncogene. 2014 Jun 5;33(23):3014-23.
10. X Li, Y Xu, Y Chen, S Chen, X Jia, T Sun, Y Liu, X Li, R Xiang*and Na Li*. SOX2 promotes tumor metastasis by stimulating epithelial-to-mesenchymal transition via regulation of WNT/β-catenin signal network. Cancer Letters 2013 Aug 19;336(2):379-89. *corresponding author
11. A Tjondrokoesoemo, Na Li, PH Lin, Z Pan, CJ Ferrante, N Shirokova, M Brotto, N Weisleder and J Ma. Type 1 inositol (1,4,5)-trisphosphate receptor activates ryanodine receptor 1 to mediate calcium sparks signaling in adult mammalian skeletal muscle. J. Biol. Chem. 2013 Jan 25;288(4):2103-9.
12. S Chen, Y Xu, Y Chen, X Li, W Mou, L Wang, Y Liu, RA Reisfeld, R Xiang, D Lv* and Na Li*. SOX2 gene regulates the transcriptional network of oncogenes and affects tumorigenesis of human lung cancer cells. PLOS one 2012 7(5):e36326; 2012 May 15. *Corresponding author
13. D Lv, S Chen, X Tan, Na Li, C Liu, Z Li, Z Liu, D Stupack, R Reisfeld, and R Xiang. Fra-1 Promotes Chemosensitivity of Breast Tumors by Driving Cancer Stem Cells out of Dormancy. Cancer Research 2012 Jul 15;72(14):3451-6.
14. Z Zhang, J Yin, C Zhang, N Liang, N Bai, A Chang, Y Liu, Z Li, X Tan, Na Li, D Lv, R Xiang, Y Tian, and C Liu. Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer Biology & Therapy 2012 April 13 (8), 1-8.
15. X Jia, X Li, Y Xu, S Zhang, W Mou, Y Liu, Y Liu, D Lv, CH Liu, X Tan, R Xiang, Na Li*. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. Journal of Molecular Cell Biology 2011 Aug;3(4):230-8. *Corresponding author
16. J Hu, K Qin, Y Zhang, J Gong, Na Li, D Lv, R Xiang and X Tan. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca(2+) influx in breast cancer cells. Biochem Biophys Res Commun. 2011 Aug 12; 411(4):786-91.
17. X Shen#, Na Li#, H Li, T Zhang, F Wang, Q Li. Increased prevalence of T regulatory cells in the tumor microenvironment and its correlation with TNM stage of hepatocellular carcinoma. Journal of Cancer Research and Clinical Oncology 2010 Nov;136(11):1745 - 54. #Equal contribution
18. HM Ni, CJ Baty, Na Li, W Gao, WX Ding, M Li, X Chen, J Ma, GK Michalopoulos and XM Yin. Bid Regulates Murine Hepatocyte Proliferation by Controlling ER Calcium Homeostasis. Hepatology 2010 Jul;52(1):338-48.
19. Na Li, P Lin, C Cai, Z Pan, N Weisleder, J Ma. The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells. Am. J. Physiol.-Cell Physiology 2009 Feb; 296(2):C267-72.
20. Na Li, L Zheng, P Lin, D Danielpour, Z Pan, J Ma. Overexpression of Bax induces down-regulation of store-operated calcium entry in prostate cancer cells. J. Cell Physiol. 2008 Jul; 216(1):172-9.
21. C Cai, P Lin, K Cheung, Na Li, C Levchook, Z Pan, F Christopher, GL Boulianne, JK Foskett, D Danielpour, and J Ma. The presenilin-2 loop peptide perturbs intracellular Ca2+ homeostasis and accelerates apoptosis. J. Biol. Chem. 2006 Jun; 281(24):16649-55.

六、讲授课程
1.病理生理学实验
2.病理生理学
3.科研方法论

七、荣誉和奖励
1.所指导研究生及研究课题 “SOX2 promotes tumor metastasis by stimulating the process of epithelial-mesenchymal transition” 获得国际会议-102次美国肿瘤年会(2011年)Scholar-in-Training奖励

八、联系方式
1. 通讯地址:天津市卫津路94号南开大学医学院
2. 电话:022-23509779
3. E-mail:lina08@nankai.edu.cn