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中国人民解放军总医院
临床教学医院
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谭小月

 

姓名:谭小月
职称:教授
一、教育经历
2001.9-2004.7中国医学科学院/中国协和医科大学北京协和医院, 医学博士学位
1991.9-1998.7湖南医科大学临床医学系七年制, 医学硕士学位
二、工作经历
2013.12- 南开大学医学院,教授
2008.06-2013.12 南开大学医学院,副教授
2004.08-2008.05 美国匹兹堡大学医学中心病理系 博士后
1998.08-2001.08 中南大学湘雅医学院附属第二医院 医师
三、研究方向
1. 纤维化相关肿瘤微环境维持肿瘤干细胞“niche”的机制
2. 上皮向间充质转分化在肿瘤转移及纤维化形成中的作用;
3. Vitamin D及其受体在治疗纤维化相关疾病中的作用及其机制。
作为项目负责人的科研项目:
①天津市自然科学基金面上项目(2016-2018)
M2巨噬细胞通过legumain重塑肿瘤微环境的机制研究
②国家自然科学基金面上项目 (2012-2016):
M2巨噬细胞表达Legumain促进肾间质纤维化损伤修复的机理及应用研究
③ 2013年度教育部“新世纪优秀人才支持计划”( 2014-2016):
纤维化关键调控蛋白参与肿瘤干细胞niche形成
④ 国家自然科学基金青年基金 (30900540, 2010-2013):
维生素受体介导炎症促进肾小管上皮细胞向间充质转分化的作用研究
⑤ 天津市应用基础与前沿技术研究计划重点项目( 2009-2012)
维生素D治疗慢性肾间质纤维化的机理研究
⑥教育部回国留学人员启动基金 (2010-2012)
维生素D受体激动剂在慢性肾病中的治疗作用
作为课题骨干参与科研项目
① 国家重大研究计划项目(2011-2015 )
哺乳动物后肾发育重要环节及关键调控因子的研究
② 国家重大研究计划项目(2012-2016 )
肿瘤干细胞在实体肿瘤发展中的调控机制研究
四、学术兼职
1. Member of AACR (美国肿瘤研究协会会员)
2. Member of ASN (美国肾脏病协会会员)
3. 中国抗癌协会会员
4. 自然科学基金青年基金及、面上项目同行评议专家
五、主要论文
1. Zhang Y, Shen L, Stupack DG, Bai N, Xun J, Ren G, Han J, Li L, Luo Y, Xiang R, Tan X#.JMJD3 promotes survival of diffuse large B-cell lymphoma subtypes via distinct mechanisms.Oncotarget. 2016 May 17;7(20):29387-99.
2.Shen L, Li H, Shi Y, Wang D, Gong J, Xun J, Zhou S, Xiang R, Tan X#.M2 tumour-associated macrophages contribute to tumour progression via legumainremodelling the extracellular matrix in diffuse large B cell lymphoma.Sci Rep. 2016 Jul 28;6:30347.
3. Shen L, Qin K, Wang D, Zhang Y, Bai N, Yang S, Luo Y, Xiang R, Tan X#. Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation. BiochimBiophysActa. 2014 Jul 25.
4. Liu Z, Xiong M, Gong J, Zhang Y, Bai N, Luo Y, Li L, Wei Y, Liu Y, Tan X#, Xiang R#. Legumain protease-activated TAT-liposome cargo for targeting tumours and their microenvironment. Nat Commun. 2014 Jun 27;5:4280.
5. Zhang Y, Guo Q, Zhang Z, Bai N, Liu Z, Xiong M, Wei Y, Xiang R#, Tan X#. VDR Status Arbitrates the Prometastatic Effects of Tumor-Associated Macrophages. Mol Cancer Res. 2014 Aug;12(8):1181-91.
6. Bai N, Zhang C, Liang N, Zhang Z, Chang A, Yin J, Li Z, Luo N, Tan X, Luo N, Luo Y, Xiang R, Li X, Reisfeld RA, Stupack D, Lv D, Liu C. Yes-associated protein (YAP) increases chemosensitivity of hepatocellular carcinoma cells by modulation of p53. Cancer BiolTher. 2013 Jun;14(6):511-20.
7. Liu Z, Lv D, Liu S, Gong J, Wang D, Xiong M, Chen X, Xiang R, Tan X#. Alginic acid-coated chitosan nanoparticles loaded with legumain DNA vaccine: effect against breast cancer in mice. PLoS One. 2013;8(4):e60190. doi: 10.1371/journal.pone.0060190.
8. Xiong M, Gong J, Liu Y, Xiang R, Tan X#. Loss of vitamin D receptor in chronic kidney disease: a potential mechanism linking inflammation to epithelial-to-mesenchymal transition. Am J Physiol Renal Physiol. 2012 Oct;303(7):F1107-15.
9. Lu D, Chen S, Tan X, Li N, Liu C, Li Z, Liu Z, Stupack DG, Reisfeld RA, Xiang R. Fra-1 promotes breast cancer chemosensitivity by driving cancer stem cells from dormancy. Cancer Res. 2012 Jul 15;72(14):3451-6.
10. Zhang M, Liu M, Xiong M, Gong J, Tan X#. Schisandrachinensis fruit extract attenuates albuminuria and protects podocyte integrity in a mouse model of streptozotocin-induced diabetic nephropathy. J Ethnopharmacol. 2012 May 7;141(1):111-8.
11. Zhang Z, Yin J, Zhang C, Liang N, Bai N, Chang A, Liu Y, Li Z, Tan X, Li N, Lv D, Xiang R, Tian Y, Liu C.Activating transcription factor 4 increases chemotherapeutics resistance of human hepatocellular carcinoma. Cancer BiolTher. 2012 Apr;13(6):435-42.
12. Hu J, Qin K, Zhang Y, Gong J, Li N, Lv D, Xiang R, Tan X#. Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca2+ influx in breast cancer cells. BiochemBiophys Res Commun. 2011 Aug 12;411(4):786-91.
13. Jia X, Li X, Xu Y, Zhang S, Mou W, Liu Y, Liu Y, Lv D, Liu CH, Tan X, Xiang R, Li N. SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell. J Mol Cell Biol. 2011 Aug;3(4):230-8.
14. Tan X, He W, Liu Y. Combination therapy with paricalcitol and trandolapril reduces renal fibrosis in obstructive nephropathy. Kidney Int. 2009;76:1248-1257. (IF= 6.193)
15. Li Y, Tan X, Dai C, Stolz DB, Wang D, Liu Y. Inhibition of integrin-linked kinase attenuates renal interstitial fibrosis. J Am SocNephrol. 2009;20:1907-1918. (IF= 7.689)
16. Tan X, Wen X, Liu Y. Paricalcitol inhibits renal inflammation by promoting vitamin D receptor-mediated sequestration of NF-kappaB signaling. J Am SocNephrol. 2008;19:1741-1752. (IF= 7.689)
17. Giannopoulou M*, Dai C*, Tan X*, Wen X, Michalopoulos GK, Liu Y. Hepatocyte growth factor exerts its anti-inflammatory action by disrupting nuclear factor-kappaB signaling. Am J Pathol. 2008;173:30-41. (*:co-first author) (IF= 5.673)
18. Hu K, Lin L, Tan X, Yang J, Bu G, Mars WM, Liu Y. .tPA protects renal interstitial fibroblasts and myofibroblasts from apoptosis. J Am SocNephrol. 2008;19:503-514. (IF= 7.689)
19. Tan X, Li Y and Liu Y. Therapeutic role and potential mechanisms of active Vitamin D in renal interstitial fibrosis.J Steroid BiochemMol Biol. 2007: 103: 491-496. (IF= 2.655)
20. Tan X, Li Y, Liu Y. Paricalcitol attenuates renal interstitial fibrosis in obstructive nephropathy.J Am SocNephrol. 2006;17:3382-3393(IF= 7.689)
21. Tan X, Zheng FL, Yang JH, Duan L, Li Y, Zhou QG. Effect of BMP-7 on the transdifferentiation of cultured human tubular epithelial cell induced by TGF-beta1. ACTA ACADEMIAE MEDICINAE SINICAE, 2004;26:274-278.
22. Tan X, Zheng FL, Zhou QG, Duan L, Li Y. Effect of bone morphogenetic protein-7 on monocyte chemoattractant protein-1 induced epithelial-myofibroblast transition and TGF-beta1-Smad 3 signaling pathway of HKC cells. National Journal of China. 2005;85: 2607-2612.
23. Giannopoulou M, Iszkula SC, Dai C, Tan X, Yang J, Michalopoulos GK, Liu Y. Distinctive role of Stat3 and Erk-1/2 activation in mediating interferon-gamma inhibition of TGF-beta1 action. Am J Physiol Renal Physiol. 2006;290:F1234-1240. (IF=3.731)
24. Tan R, Zhang J, Tan X, Zhang X, Yang J, Liu Y. Downregulation of SnoN expression in obstructive nephropathy is mediated by an enhanced ubiquitin-dependent degradation. J Am SocNephrol. 2006;17:2781-2791. (IF= 7.689)
25. Zhou QG, Zheng FL, Wen YB, Tan X, Duan L, Li Y. Altered expression of vascular endothelial growth factor and its receptors in transdifferentiated human proximal tubular epithelial cells induced by transforming growth factor beta1. ACTA ACADEMIAE MEDICINAE SINICAE.2005;27: 325-331.
六、讲授课程
1. 病理学(临床医学系七年制&临床医学系八年制&口腔医学系五年制)
2. Pathology (MBBS in Nankai University)
2. 病理学技术
3. 病理学进展
4. 科研方法论
七、联系方式
1. 通讯地址:天津市卫津路94号南开大学医学院218室
2. 电话:022-23494031
3. E-mail:xiaoyuetan@nankai.edu.cn