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师资队伍
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中国人民解放军总医院
临床教学医院
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杨卓

姓名: 杨卓
职称: 教授
教授,博士生导师, 1983年天津医科大学获医学学士学位;1989年浙江大学医学院获医学硕士学位;1998年英国伯明翰大学医学院获博士学位。2003起至今为南开大学教授,从事生理学教学和科研工作。目前每年招收1-2名硕士生及博士生。

一、研究方向:
1围绕神经系统重大疾病,通过相关的动物模型,进行行为学、神经电生理、免疫组化及突触机制等研究。
2纳米材料在中枢神经系统的作用及其机制研究。
3 与肾发育有关的离子通道机制研究。
4海马神经通路的交互作用与神经元突触传递机制的研究。

承担项目:
国家自然科学基金项目,天津市应用基础与前沿技术研究计划重点项目等。
二、 近3年主要论文
 Li Zhigui, Hao Shuang, Yin Hongqiang, Gao Jing, Yang Zhuo. Autophagy ameliorates cognitive impairment through activation of PVT1 and apoptosis in diabetes mice. Behavioural Brain Research. 2016; 305:265–277

 Lu Xiao, Chunhua Liu, Xiaoniao Chen, Zhuo Yang. Zinc oxide nanoparticles induce renal toxicity through reactive oxygen species. Food and Chemical Toxicology. 2016; 90:76–83

 Wen Li,Yuen-Ki Cheong,Hui Wang,Guogang Ren,Zhuo Yang. Neuroprotective effects of etidronate and 2,3,3-trisphosphonate against glutamate-induced toxicity in PC12 cells. Neurochem Res.2015; 41:844-854

 Jiajia Yang, Chunxiao Yang, Chunhua Liu, Tao Zhang, and Zhuo Yang, Paradoxical Effects of VEGF on Synaptic Activity Partially Involved in Notch1 Signaling in the Mouse Hippocampus. HIPPOCAMPUS 26:589–600 (2016)

 Wei Miaomiao, Liu Chunhua, Zhang Xiaochen, Chen Xiaoniao, Lin Hongli and Yang Zhuo. Autophagy is involved in regulating VEGF during high-glucose-induced podocyte injury. Mol. BioSyst., 2016, 12, 2202—2212
 Chunhua Liu, Xiaxia Xu, Jing Gao, Tao Zhang, Zhuo Yang. Hydrogen sulfide prevents synaptic plasticity from VD-induced damage via Akt/GSK-3β pathway and Notch signaling pathway in rats. Molecular Neurobiology, 2016; (53):4159–4172
 Xiaochen Zhang, Wen Li, Zhuo Yang. Toxicology of nanosized titanium dioxide: an update. Arch Toxico, 2015; Volume 89 (12): 2207–2217
 Chunhua Liu, Hongqiang Yin, Jing Gao, Xiaxia Xu, Tao Zhang, Zhuo Yang. Leonurine ameliorates cognitive dysfunction via antagonizing excitotoxic glutamate insults and inhibiting autophagy. Phytomedicine,2016:1638-1646
 Na Gao, Hui Wang, Xiaochen Zhang & Zhuo Yang. The inhibitory effect of angiotensin II on BKCa channels in podocytes via oxidative stress. Mol Cell Biochem (2015) 398:217–222
 Xuan Qin, Ye Liu, Minghui Zhu, Zhuo Yang, The possible relationship between expressions of TRPC3/5 channels and cognitive changes in rat model of chronic unpredictable stress. Behavioural Brain Research, 2015; 290:180–186
 Zhigui Li, Lifeng Wang, Jing Xu & Zhuo Yang.MiRNA expression profile and miRNA–mRNA integrated analysis (MMIA) during podocyte differentiation. Molecular Genetics and Genomics. Mol Genet Genomics, 2015;290:863–875
 Pengjuan Xu, Zhigui Li, Qinjun Xuan, Zhuo Yang.Different expressions of large-conductance Ca2+-activated K+ channels in mouse renal cortex and hippocampus during postnatal development. Applied Immunohistochemistry & Molecular Morphology: 2015;23(2):146-52
 Ye Liu, Chunhua Liu, Xuan Qin, Minghui Zhu, Zhuo Yang. The change of spatial cognition ability in depression rat model and the possible association with down-regulated protein expression of TRPC6. Behavioural Brain Research, 2015;294:186–193
 Jing Gao, Xiaochen Zhang, Mei Yu, Guogang Ren, Zhuo Yang. Cognitive deficits induced by multi-walled carbon nanotubes via the autophagic pathway. Toxicology 337 (2015): 21–29
 Xiaochen Zhang, Wen Li & Zhuo Yang. Toxicology of nanosized titanium dioxide:an update. Archives of Toxicology. 2015; 89:2207–2217
 Minghui Zhu, Chunhua Liu, Xuan Qin, Zhuo Yang. Hyperforin alleviates mood deficits of adult rats suffered from early separation Neuroscience Letters. 608 (2015): 1–5
 Wei Miaomiao, Li Zhigui, Xiao Lu, Yang Zhuo*. Effects of ROS-relative NF-κB signaling on high glucose-induced TLR4 and MCP-1 expression in podocyte injury. Molecular Immunology, 2015;68:261–271
 Zhaowei Liu, Jiajia Yang, Xiaochen Zhang, Pengjuan Xu, Tao Zhang, Zhuo Yang.
Developmental Changes in the Expression and Function of TRPC6 Channels Related the F-actin Organization during Differentiation in Podocytes. Cell Calcium, 2015;58:541–548
 Chunhua Liu, Ye Liu, Zhuo Yang. Myocardial infarction induces cognitive impairment by increasing the production of hydrogen peroxide in adult rat hippocampus. Neuroscience Letters.2014; (560): 112-116
 Liu Zhaowei, Xie Yongling, Yang Jiajia & Yang Zhuo. The reduction of EPSC amplitude in CA1 pyramidal neurons by the peroxynitrite donor SIN-1 requires Ca2+ influx Via postsynaptic non-L-type voltage gated calcium channels. Neurochem Res. 2014;39:361-371
 Zhang Junsi, Li Yanna, Xu Jing, Yang Zhuo. The role of N-methyl-D-aspartate receptor in Alzheimer's disease. Journal of the Neurological Sciences. 2014;339:123-129
 Xu Lanju, Xu Jing, Liu Shichang, Yang Zhuo, Induction of apoptosis by antimycin A in differentiated PC12 cell line. Journal of Applied Toxicology. 2014; 651–657
 Miaomiao Wei, Zhigui Li, Zhuo Yang. Crosstalk between protective autophagy and NF-κB signal in high glucose-induced podocytes. Molecular and Cellular Biochemistry. 2014;394(1-2):261-273
 Weiwei Dai, Jiajia Yang, Ting Chen, Zhuo Yang. Protective Effects of Bexarotene against Aβ25-35-Induced Dysfunction in Hippocampal Neurons through Insulin Signaling Pathway. Neurodegenerative Diseases. 2014;14(2):77-84
 Pengjuan Xu, Zhigui Li, Xiaochen Zhang, Zhuo Yang. Increased response to oxidative stress challenge of nano-copper-induced apoptosis in mesangial cells. Journal of Nanoparticle Research, 2014; 16(12):2777,1-13
 Zhigui Li, Jing Xu, Pengjuan Xu, Shichang Liu, Zhuo Yang. Wnt/β-catenin signaling pathway mediates high glucose induced cell injury through activation of TRPC6 in podocytes. Cell Prolif., 2013, 46, 76–85

三、讲授课程
1. 生理学
2. 专业英语
3. 若干研究生及硕士生课程
四、联系方式
1. 通讯地址:南开大学医学院(八里台校区)313室
2. E-mail:zhuoyang@nankai.edu.cn