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Dwayne G. Stupack

 

姓名:Dwayne G. Stupack

职称:南开大学讲座教授

一、教育经历

1984-1988                  本科B.Sc.(Hons), Genetics遗传学

             University of Manitoba (Fort Garry), Faculty of Science,

             Winnipeg, Canada

1990 – 1996      研究生Graduate Student  to Ph.D微生物

                        Health Sciences Centre, Rheumatic Diseases Unit Laboratory

                        Dr. John A. Wilkins. (University of Manitoba, Bannatyne)

二、工作经历

  2011-current        Associate Professor of Reproductive Medicine (tenured)               

                        The University of California San Diego, Dept of Pathology,

                        The Moores Comprehensive Cancer Center, Section of Gynecological

             Oncology

2005- 2010        Assistant Professor to Associate Professor of Pathology

             The University of California San Diego, Dept of Pathology & MCC

             The Moores Comprehensive Cancer Center   

2002-2005                  Senior Research Associate (to Assistant Professor 2005)

                        The Scripps Research Institute, Dept. of Immunology.

1996-2001        Research Associate 

             The Scripps Research Institute, Dept. of Immunology.

             Dr. David A. Cheresh’s Laboratory

三、研究方向

研究主要集中在理解干预机制以预防肿瘤转移,南开大学的研究将会集中于干细胞的全能性,以及细胞粘附和相关的信号通路。

项目:

 

项目名称

项目性质及来源

项目经费

起始年度

终止年度

1

Integrins and Caspase 8 in Tumor Progression

美国NIH 基金项目

$1,415,000

2010

2015

1

2

RTS-SCA.  Real Time Secretion: Secreted Cell Anabolites

美国国家科学基金项目

$180,000

2012

2015

1

3

Integrins and Caspase 8 in Tumor Progression

美国NIH 基金项目

$91,500

2009

2010

1

4

Nine Girls Ask Foundation Grants in Aid

Private Foundation Grant私人基金会的资助

 

$50,000

2014

2015

1

5

Nine Girls Ask Foundation Grants in Aid

Private Foundation Grant私人基金会的资助

 

$50,000

2012

2013

1

6

Center of Nanotechonology for Treatment, Understanding, and Monitoring of Cancer

美国NIH 基金项目

$21,627,310

2005

2010

 

7

Integrins and Caspase 8 in neuroblastoma Progression

美国NIH 基金项目

$1,500,000

2004

2009

1

8

Planning Grant for In Vivo Cellular and Molecular Imaging Centers (ICMICs)

美国NIH 基金项目

$7,500,000

2007

2012

 

9

Rho- and GPCR-mediated signaling through cellular effectors

美国NIH 基金项目

$1,250,000

2007

2012

 

10

Preclinical testing of a focal adhesion kinase inhibitor

Poniard (Industrial Grant) (工业项目)

 

$400,000

2008

2009

1

四、学术兼职

Reviewer:      Nation/Agency:   

              USA: CDMRP (Breast Cancer, CBY5, 2010)

              NIH-NCI (TCB CSR Study section, 2007, ad hoc, ARRA 2009),

              NIH-NIAIDS (ZRG series Special Review Panel, 2008, 2009),

              NIH-NCI (TME CSR Study section, 2011 ),

              Leukemia and Lymphoma Society Career Development Panel

              American Cancer Society (Grants in Aid, San Diego Chapter)

              Foundation for Melanoma Research,

              Canada: Heritage Foundation

              France: ARC(Associatione Recherche de Cancre),ANR(Association

                 Nationale de Recherche) 

              Singapore: Medical Research Council, 

                   Qatar: Qatar National Research Fund

Professional Review(专业评审)

CDMRP Breast Cancer Review Panel CBY5                                           2010

NIH (NCI & NIAID) reviewer (Ad Hoc)                                           2007-2009, 2011-2014

NIH (NCI) TME Study section                            2013-2017

五、近五年论文

1.       Cheresh, D.A. and Stupack, D.G*.  Regulation of angiogenesis: apoptotic cues from the ECM.  Oncogene, 27:6285-6298, 2008.

2.       Barbero, S., Barila, D., Mielgo A., Clair, K, Stagni, V., and Stupack D.G.*  Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.  J Biol Chem. 283:13031-13035, 2008. Featured Article in the Journal

3.       Wrasidlo, D.G., Mielgo, A., Torres, V. Barbero, S., Stolenov, K., Gerwick, W., Carson, D., and D.G. Stupack*. The marine lipopeptide Somocystinamide A triggers apoptosis via caspase 8. Proc Nat Acad Sci USA 105;2313-2318,  2008.

4.       Torres, V.A., Mielgo,A., Barila, D., Anderson, D.H. and D.G. Stupack*. Caspase 8 promotes peripheral localization and activation of Rab5.  J. Biol. Chem. 283:36280-36289, 2008.Featured Article in the Journal

5.       Barbero, S., Mielgo, A., Torres, V., Teitz, T, Shields, D.J., Mikolon D., Bogyo., M., Barila, D., Lahti., J.M., Schlaepfer, D., and Stupack., D.G*.  Caspase 8 association with the focal adhesion complex promotes tumor cell migration and metastasis.  Cancer Res.  69:3755-3763, 2009.

6.       Mielgo, A., Torres, V.A., Barbero, S., and Stupack, D.G*.  Paclitaxel promotes a caspase 8-mediated apoptosis via death effector domain association with microtubules.  Oncogene, doi: 10.1038/onc.2009.210, 2009.

7.       Mielgo, A., Torres, V.A., Schmid, M.C., Graf, R., Zeitlin, S.G., Lee., P., Shields, D.J.,  , Barbero, S., Jamora, C., and Stupack, D.G.*  The death effector domains of caspase-8 induce terminal differentiation.  PloS One, doi:10.1371/journal.pone.0007879, 2009.

8.       Torres, V.A., Mielgo, A., Barbero, S., Hsiao, R., Wilkins, J.A. Stupack D.G*.  Rab5 Mediates Caspase-8 Promoted Cell Motility and Metastasis.   Mol Biol Cell, 21:369-376 2010*Editor’s choice/nominee for paper of the year in MBoC.

9.       Walsh, C., Tanjoni, I., Uryu, S., Tomar, A., Nam, J-O., Luo, H., Phillips, A., Patel, N., Kwok, C., McMahon, G., Stupack, D.G*., and Schlaepfer D.D.* Oral Delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models.  Cancer Biol Ther 9:778-790, 2010. * Stupack and Schlaepfer are ‘co-senior’ authors on this manuscript.

10.   Tanjoni, I., Walsh, C., Uryu, S., Tomar, A., Nam, J-O., Mielgo A., Lim, S-T., Liang, C., Koenig, M.,  Patel, N., Kwok, C., McMahon, G., Stupack, D.G*., and Schlaepfer D.D.* PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments.  Cancer Biol Ther 9, 764-777, 2010.  PMID: 20234191  * Stupack and Schlaepfer are ‘co-senior’ authors on this manuscript.

11.   Murphy, E., and Stupack, D.G*.  Vitronectin binding integrins in cancer.  In Cell-Extracellular Matrix Interactions in Cancer. Springer-Verlag.,  Eds. Zent, R., & Pozzi, A. 137-170, 2010 doi:10.1007/978-a-4419-0814-8_7.

12.   Stupack, D.G. Caspase-8 as a therapeutic target in cancer.  Cancer Lett epub ahead of print.  PMID20817393 2010.

13.   Torres V.A, Stupack, D.G*. Rab5 in the regulation of cell motility and invasion.  Current Protein Pep Sci 12:43-51, 2011.

14.   Yuan, R., Lio, J., Mielgo, A, Schmid, M. Stupack, D.G*.  Caspase-8 isoform 6 promotes death effector filament formation independent of microtubules. Apoptosis 17:229-235, 2012.

15.   Mendoza P, Ortiz R, Díaz J, Quest AF, Leyton L, Stupack DG, Torres VA. Rab5 Activation Promotes Focal Adhesion Disassembly, Migration and Invasiveness of Tumor Cells. J Cell Sci. 2013 Jun 26. [Epub ahead of print] PubMed PMID:23813952.

16.   Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.G*.. Src-inducible association of CrkL with procaspase-8 promotes cell migration. Cell Adh Migr. 2013 Jun 10;7(4). [Epub ahead of print] PubMed PMID: 23751956

六、讲授课程

Molecules to Disease/从分子到疾病

Molecular and Cell Biology/分子和细胞生物学

Seminars in Pathology/病理学讲座

Methods in Molecular Pathology/分子病理学方法

Cell Biology/细胞生物学

Direct Study Research/直接学习研究

Oncology Block/原癌基因阻断

七、联系方式

The University of California San Diego, Dept of Pathology

Office Address:      The Moores UCSD Cancer Center

                                3855 Heath Sciences Drive MC 0803

                                La Jolla, CA, 92093 803

       Office Telephone:   858 822 1150

              FAX:              858 822 1975

 

              email:            dstupack@ucsd.edu