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孙培庆

 

姓名:孙培庆

职称:南开大学讲座教授

一、教育经历

Department of Genetics and Genetic Engineering B.S.                   1983-1987                

Fudan Unviversity, Shanghai, PRC

Graduate Student, Institute of Genetics                                              1987-1989

Fudan University, Shanghai, PRC

Genetics Ph.D. Program           Ph.D.                                  1989-1995

University of Iowa, Iowa City, IA                                          

Cold Spring Harbor Laboratory                     Postdoctoral Fellow   1995-1999

Cold Spring Harbor, NY

二、工作经历

1995-1999             Postdoctoral fellow,

                Cold Spring Harbor Laboratory, Cold Spring Harbor, NY

Dec.1999-Jan 2006  Assistant Professor

Department of Molecular Biology, The Scripps Research Institute, La           Jolla, CA 

Jan. 2006-         Associate Professor

Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA

三、研究方向

研究细胞衰老和抗肿瘤相关的分子和信号通路。

项目:

 

项目名称

项目性质及来源

项目经费

起始年度

终止年度

1

The role of microRNA in Oncogene-induced Senescence and Cancer Development

美国NIH基金项目

$378000每年

2014

2019

 

2

p38 MAPK in Ras-induced Senescence and Transformation

美国NIH基金项目

$319767每年

2005

2015

 

3

Tip60 in p38 and PRAK Mediated Oncogene-Induced Senescence and Tumor Suppression

美国NIH基金项目

$382221每年

2009

2014

 

4

Globeal Gene Functional Analysis with siRNA Libraries

美国NIH基金项目、通过Cellecta公司

$400289总计

2010

2012

 

5

PRAK as an adjunctive marker for preoperative diagnosis of thyroid cancer

美国NIH基金项目,通过Scripps Institute

$94950总计

2009

2010

 

6

p53-independent Role of MDM2, TGF-beta Resistance and Cancer

美国NIH基金项目

$321909每年

2002

2008

 

 

 

 

 

 

 

 

四、学术兼职

Member of Editorial Board, Protein and Cell (Protein and Cell 杂志编委)

退役军人管理部科研基金审查委员会肿瘤学组成员(Oncology study section, National Merit Review Board, Veterans Administration

美国NIH科研基金审查中心癌症分子病理生物学组(CAMP),分子肿瘤学组(MONC)和Provovative Questions Special Review Panel成员

美国国防部乳腺癌研究基金细胞生物学审查组成员

CellScience Science Signaling EMBO JPNASCancer ResMCB等杂志审稿人

五、近五年论文

1.                  Sun P*, Yoshizuka N, New L, Moser BA, Li Y, Liao R, Xie C, Chen J, Deng Q, Yamout M, Dong M, Frangou CG, Yates, JR III, Wright PE and Han J*, 2007. PRAK is Essential for Oncogenic ras-Induced Senescence and Tumor Suppression. Cell 128:295-308.

 

2.                  Kannemeier C, Liao R and Sun P*, 2007. The RING Finger Domain is Essential for MDM2-mediated TGF-b Resistance. Mol. Biol. Cell 18:2367-2377.

 

3.                  Han J*. and Sun P*, 2007. The Pathways to Tumor Suppression via Route p38. Trends Biochem. Sci. 32:364-371.

 

4.                  Wang K, Cheng C, Li L, Liu H, Huang Q, Xia CH, Yao K, Sun P, Horwitz J, Gong X*, 2007. gD-Crystallin Associated Protein Aggregation and Lens Fiber Cell Denucleation. Invest. Ophthalmol. Vis. Sci. 48:3719-3728.

 

5.                  Liu E, Lee A, Chiba T, Olson . Sun P and Wu X*. 2007 ATR-mediated S-phase checkpoint prevents DNA rereplication in mammalian cells when the licensing control is disrupted. Journal of Cell Biology. 179:643-57.

 

6.                  Kwong J, Hong L, Liao R, Deng Q, Han J and Sun P*. 2009 p38α and p38γ Mediate oncogenic RAS-induced senescence through differential mechanisms. J. Biol.Chem. 284:11237-46. (PMC2670128)

 

7.                  Ren JL, Pan JS, Lu YP, Sun P, Han J*. 2009 Inflammatory signaling and cellular senescence. Cell Signal. 21:378-83. (PMC2870712)

 

8.                  Wu C-C, Wu X, Han J, and Sun P*. 2010 p38g Regulates UV-Induced Checkpoint Signaling and Repair of UV-Induced DNA Damage. Protein Cell 1:573-583. (PMC3002048)

 

9.                  Hong L, Lai M, Chen M, Xie C, Liao R, Kang YL, Xiao C, Hu W-Y, Han J*, and Sun P*. 2010. The miR-17-92 Cluster of microRNAs Confers Tumorigenicity by Inhibiting Oncogene-Induced Senescence. Cancer Res. 70:8547-57. Epub 2010 Sep 17. (PMC2970743)

 

10.              Zheng M, Wang YH, Wu XN, Wu SQ, Lu BJ, Dong MQ, Zhang H, Sun P, Lin SC, Guan KL, Han J*. 2011 Inactivation of Rheb by PRAK-mediated phosphorylation is essential for energy-depletion-induced suppression of mTORC1. Nat Cell Biol. 13:263-72. Epub 2011 Feb 20. (PMCID in process)

 

11.              Yoshizuka N, Chen RM, Xu Z, Liao R, Hong L, Hu W-Y, Yu G, Han J, Chen L, Sun P*. 2012. A Novel Function of p38-Regulated/Activated Kinase (PRAK) In Endothelial Cell Migration and Tumor Angiogenesis. Mol Cell Biol. 32(3):606-18. Epub 2011 Nov 28.

 

12.     Yoshizuka N, Lai M, Liao R, Cook R, Xiao C, Han J, Sun P*. 2012. PRAK suppresses oncogenic ras-induced hematopoietic cancer development by antagonizing the JNK pathway. Mol Cancer Res. 10:810-820. Epub 2012 Jun 4.

 

13.              Kolesnichenko M*, Hong L, Liao R, Vogt PK, Sun P. 2012. Attenuation of TORC1 signaling delays replicative and oncogenic Ras-induced senescence. Cell Cycle. 11(12):2391-2401.

 

14.              Zheng H, Seit-Nebi A, Han X, Aslanian A, Tat J, Liao R, Yates JR III, Sun P*. 2013. A posttranslational modification cascade involving p38, Tip60 and PRAK mediates oncogene-induced senescence. Molecular Cell 50:699-710.

 

15.              Kwong J, Chen M, Lv D, Luo N, Xiang R and Sun P*. 2013. Induction of p38d expression plays an essential role in oncogenic ras-induced senescence. Mol. Cell. Biol. 33:3780-3794.

六、讲授课程

Molecular Biology

 

七、联系方式

Dr. Peiqing Sun

Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037.

 

pqsun@scripps.edu (e-mail)