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师资队伍
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中国人民解放军总医院
临床教学医院
 254医院硕士生导师
 口腔医院硕士生导师
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陈元利

姓名:陈元利
职称:讲师

一、教育经历
2009-2014:南开大学,生物化学与分子生物学系,博士
2005-2009:南开大学,生物科学专业,学士

二、工作经历
2014.7-至今南开大学医学院,讲师

三、研究方向(包括承担课题项目)
1. 动脉粥样硬化病理机制研究
2. 脂代谢与肿瘤
3. 非酒精性脂肪肝发病机制和治疗策略

承担课题项目:
1. 中国博士后科学基金面上资助:25-羟胆固醇体内合成自调控与抗病毒功能和机理的研究,项目编号:2015M570226,一等,在研,主持。
2. 国家自然科学基金青年科学基金:25-羟基胆固醇体内合成自调控与抗病毒功能和机理的研究,项目编号:31400694,2015年1月-2017年12月。在研,主持。
3. 国家自然科学基金面上项目:DNA拓扑异构酶II抑制剂促进动脉粥样硬化斑块消退,项目编号:81473204,2015年1月-2018年12月。在研,参与。

四、学术兼职
中国生物化学与分子生物学会脂蛋白专业委员会青年委员

五、近5年发表论文(#:共同第一作者;*:通讯作者)
1. Liu M, Zhang W, Li X, Han J, Chen Y*, Duan Y*. Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. Biochemical and Biophysical Research Communications. 2016;469:456-462.
2. Yang X, Sun L, Li Y, Ma C, Yang J, Zhang W, Zhao B, Jia L, Duan Y, Han J, Li X*, Chen Y*. NaoXinTong inhibits the advanced atherosclerosis and enhances the plaque stability in apoE deficient mice. Journal of Cardiovascular Pharmacology, 2016;67:203-211.
3. Yang X, Yao H, Chen Y, Sun L, Li Y, Ma X, Duan S, Li X, Xiang R, Han J, Duan Y*. 2015. Inhibition of glutathione production induces macrophage CD36 expression and enhances cellular oxLDL uptake.The Journal of Biological Chemistry, 2015;290:21788-99.
4. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li X, Han J*, Duan Y*. Administration of Danhong Injection to diabetic db/db mice inhibits the development of diabetic retinopathy and nephropathy. Scientific Reports.2015;5:11219.
5. Liu M, Chen Y, Zhang L, Wang Q, Ma X, Li X, Xiang R, Zhu Y, Qin S, Yu Y, Jiang X, Duan Y, Han J*. Regulation of hepatic cholesteryl ester transfer protein expression and reverse cholesterol transport by inhibition of DNA topoisomerase II. The Journal of Biological Chemistry 2015, 290(23):14418-29.
6. Zhang W, Wang X, Hu W, Liu L, Li X, Han J, Chen Y*, Duan Y*. Co-treatment of pitavastatin and dexamethasone exacerbates the high fat diet-induced atherosclerosis in apoE-/- mice. Journal of Cardiovascular Pharmacology, 2015;66:189-95.
7. Ma X, Liu Y, Wang Q, Chen Y, Liu M, Li X, Xiang R, Wei Y, Duan Y, Han J. Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. Biochimica et Biophysica Acta-Molecular Basis of Disease, 2015;1852:1038-1048.
8. Chen Y#, Duan Y#, Yang X, Sun L, Liu M, Wang Q, Ma X, Zhang W, Li X, Hu W, Miao QR, Xiang R, Hajjar DP, Han J. Inhibition of ERK1/2 and activation of LXR synergistically reduce atherosclerotic lesions in apoE deficient mice. Arteriosclerosis Thrombosis and Vascular Biology, 2015;35:948-959.
9. Liu M, Pan Q, Chen Y, Yang X, Zhao B, Jia L, Zhu Y, Han J, Li X, Duan Y. NaoXinTong inhibits the development of diabetic retinopathy in db/db mice. Evidence-Based Complementary and Alternative Medicine,Volume 2015; Article ID 242517, 8 pages, http://dx.doi.org/10.1155/2015/242517.
10. Ma X, Wang Q, Liu Y, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao RQ, Duan Y, Han J. Inhibition of tumor growth by U0126 is associated with induction of interferon-production.International Journal of Cancer 2015;136:771-83.
11. Wang Q, Ma X, Chen Y, Zhang L, Jiang M, Li X, Xiang R, Miao R, Hajjar DP, Duan Y, Han J. Identification of interferon- as a new molecular target of liver X receptor. Biochemical Journal2014;459:345-354.
12. Chen Y#, Liu M#, Zhao T, Zhao B, Jia L, Zhu Y, Zhang B, Gao X, Li G, Li X, Xiang R, Han J, Duan Y. Danhong Injection inhibits the development of atherosclerosis in both Apoe-/- and Ldlr-/- mice. Journal of cardiovascular Pharmacology 2014;63:441–452.
13. Liu M#, Chen Y#, Yang X, Zhang L, Zhao T, Zhao B, Jia L, Zhu Y, Gao X, Zhang B, Li X, Han J, Duan Y. Danhong injection inhibits the development of primary abdominal aortic aneurysms in apoE knockout mice. Chinese Science Bulletin2014;59:1366-1373.
14. Jiang M, Zhang L, Ma X, Hu W, Chen Y, Yu M, Wang Q, Li X, Yin Z, Zhu Y, Gao X, Hajjar DP, Duan Y, Han J. Tamoxifen inhibits macrophage FABP4 expression through the combined effects of the GR and PPAR pathways.Biochemical Journal 2013;454:467-477.
15. Zhang L, Jiang M, Shui Y, Chen Y, Wang Q, Hu W, Ma X, Li X, Liu X, Cao X, Liu M, Duan Y, Han J. DNA topoisomerase II inhibitors induce macrophage ABCA1 expression andcholesterol efflux---an LXR-dependent mechanism. BBA - Molecular and Cell Biology of Lipids 2013;1831:1134-45.
16. Chen Y,Duan Y, Kang Y, Yang X, Jiang M, Zhang L, Li G, Yin Z, Hu W, Dong P, Li X, Hajjar DP, Han J. Activation of liver X receptor induces macrophage interleukin-5 expression. The Journal of Biological Chemistry2012;287:43340-50.
17. Duan Y#,Chen Y#, Hu W, Li X, Yang X, Zhou X, Yin Z, Kong D, Yao Z, Hajjar DP, Liu L, Liu Q, Han J. Peroxisome Proliferator-activated receptoractivation by ligands and dephosphorylation induces proprotein convertase subtilisin kexin type 9 and low density lipoprotein receptor expression. The Journal of Biological Chemistry 2012;287:23667-77.
18. Hu W, Zhou X, Jiang M, Duan Y, Chen Y, Li X, Yin Z, He GW, Yao Z, Zhu Y, Hajjar DP, Han J. Statins synergize dexamethasone-induced adipocyte fatty acid binding protein expression in macrophages. Atherosclerosis2012;222:434-43.
19. Dong P, Xie T, Zhou X, Hu W, Chen Y, Duan Y, Li X, Han J. Induction of macrophage scavenger receptor type BI expression by tamoxifen and 4-hydroxytamoxifen. Atherosclerosis2011;218:435-42.
20. 杨潇潇,刘力沛,孙蕾,李小菊,段亚君,陈元利*.过氧化物酶体增殖物激活受体gamma 激动剂和促分裂原活化蛋白激酶1/2抑制剂药物组合对Apoe-/-小鼠动脉粥样硬化发展的抑制作用. 中国动脉硬化杂志. 2015,23(08):763-768.


六、讲授课程
临床医学留学生《Experiment in cell biology》

七、荣誉和奖励
1. 2012年,博士研究生国家奖学金
2. 2013年,博士研究生国家奖学金
3. 2014年10月,《第十二届全国脂质与脂蛋白学术会议》“阳普杯”青年论文大赛二等奖

八、联系方式
1.通讯地址:天津市南开区卫津路94号
2.电话:23501776
3. E-mail:yuanli2014@nankai.edu.cn