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中国人民解放军总医院
临床教学医院
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刘娜

姓名:刘娜
职称:副研究员

一、教育经历
1996.9-2001.6 中国药科大学理学学士
2003.9-2008.5 中国医学科学院血液学研究所博士学位

二、工作经历
2008-2011 南开大学生科院,讲师
2012-2016 南开大学生科院,副研究员
2013-2014 耶鲁大学,访问学者
2016-至今南开大学医学院,副研究员


三、研究方向:干细胞生物学
(一)研究领域:
1. 胚胎干细胞多能性维持机制;
2. 干细胞分化调控机制研究;
(二)主持及参与的科研课题:
1. 天津市自然科学基金重点项目“先天性角化不良发病机制探究”,起止日期 2014.3-2017.4,项目负责人
2.国家自然科学基金青年基金“印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究”,起止日期 2011.1-2013.12,项目负责人
3. 中央高校基本科研业务费专项资金“印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究”,起止日期 2010.6-2012.5,项目负责人
4. 国家科技部重大科学研究计划“猪诱导多能干细胞(iPS)及其分化发育研究”,起止日期 2009.1-2013.8,研究骨干
5.天津市自然科学基金重点项目“端粒相关蛋白在多能性干细胞中的作用及调控”,起止日期2012.4-2015.3,主要参与人
6. 国家科技重大科学研究计划子课题:“端粒相关蛋白在基因表达调控及细胞分化中的作用”,起止日期:2012.1-2016.8,子课题学术骨干


四、学术兼职
1.2010-至今中国细胞生物学学会会员

五、发表论文:

1. Ningning He, Guowei Feng, Yang Li, Yang Xu, Xiaoyan Xie, Hui Wang, Yuebing Wang, Lailiang Ou, Xuetao Pei, Na Liu*, and Zongjin Li*. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95
2. Na Liu, Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells.Sci Rep. 2016, 6:28739.
3. GuoweiFeng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, JieGao, Na Liu,Ningning He, Wei Du, Hongyan Tao, YongzheChe, Yong Xu, Deling Kong, Qiang Zhao, and Zongjin Li*. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI.J Am SocNephrol. 2016, 27(8):2357-69.
4. Zhenrong Zhao, Xinghua Pan, Lin Liu* andNa Liu*. Telomere Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2014 229(10): 1323-9.
5. Dan J#, Liu Y#,Liu N#,Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014. 29(1): 7-19.
6. Yu Yin#, Na Liu#, Xiaoying Ye, RenpengGuo, JieHao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein Cell. 2014 5(1): 8-11
7. Yu Yin, Haiying Wang, Kai Liu, Fang Wang, Xiaoying Ye, Mengyuan Liu, Rong Xiang, Na Liu*, Lin Liu*, Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014; 14(6): 737-48.
8. Na Liu, Lin Liu, Xinghua Pan, Single cell analysis on transcriptome and its application in the identification of stem cells. Cellular and Molecular Life Science, 2014 71(14): 2707-15.
9. Liu N,Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide gene expression profiling reveals aberrant MAPK and wnt signaling pathways associated with early parthenogenesis.Journal of Molecular Cell Biology. 2010; 2:333-344.
10. Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.Journal of Cell Biochemistry. 2009;106:1041-1047.
11. Liu N,Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of genes regulated by Nanog which is involved in ES cells pluripotency and early differentiation.Journal of Cell Biochemistry. 2008; 104:2348-2362.
12. Yin Y, Liu N, Keefe D, and Liu L. Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.
13. Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015 6(2): 152-6.
14. Huang J, Wang F, Okuka M, Liu N,Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011; 21:779-792.
15. Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, ChioureaM, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell Research 2012; 22: 757-768.
16. Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013 23:162–166.
17. Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells. 2013; 31(11):2538-50.
18. Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2013; 97:208-18.
19. Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L. Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction 2012; 27: 1411-1420.
20. Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J,Liu N,Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open 2012; 1:1118-27.
21. Ji G, Liu K, Okuka M, Liu N,Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012;13:36.


六、讲授课程
1.细胞生物学
2.干细胞与再生医学

七、荣誉和奖励
1.2012年南开大学教学成果奖校级二等奖
2.2016年南开大学青年教师教学基本功竞赛校级二等奖


八、联系方式
1.通讯地址:天津市卫津路94号南开大学医学院304
2.电话:022-23509332
3. E-mail:liuna@nankai.edu.cn