姓名：张博崴

职称：讲师

一、教育经历

2014.9-2018.7大连理工大学，生物化工专业，博士学位

2011.9-2014.7大连理工大学，生物化工专业，硕士学位

2007.9-2011.6辽宁大学，生物技术专业，学士学位

二、工作经历

2018.7-至今南开大学医学院，讲师

三、研究方向(包括承担课题项目)

1.天然药物和食品活性成分改善糖尿病的机制

2.膳食营养与肠道菌群的相互作用

2.黄酮的肠道代谢

四、近5年发表论文

1.ZhangB,Sun W, Yu N, Sun J, Yu X, Li X, Xing Y, Yan D, Ding Q, Xiu Z, Ma B,Yu L, Dong Y*. Anti-Diabetic Effect of Baicalein is Associated withthe Modulation of Gut Microbiota in Streptozotocin and High-Fat-DietInduced Diabetic Rats. Journalof Functional Foods,2018, 46:256-267. (I区TOP)

2.ZhangB,Li X, Sun W, Xing Y, Xiu Z, Zhuang C, Dong Y*. Dietary Flavonoids andAcarbose Synergistically Inhibit α-Glucosidase and LowerPostprandial Blood Glucose. Journalof Agricultural and Food Chemistry,2017, 65:8319−8330. (I区TOP)

3.ZhangB,Sang Y, Sun W, Yu H, Ma B, Xiu Z, Dong Y*. Combination of Flavonoidsfrom OroxylumindicumSeed Extracts and Acarbose Improves the Inhibition of PostprandialBlood Glucose: InVivoand InVitroStudy. Biomedicine& Pharmacotherapy,2017, 91:890-898.

4.ZhangB,Xing Y, Wen C, Yu X, Sun W, Xiu Z, Dong Y*. Pentacyclic Triterpenesas α-Glucosidase and α-Amylase Inhibitors: Structure-activityRelationships and the Synergism with Acarbose. Bioorganic& Medicinal Chemistry Letters,2017, 27:5065-5070.

5.Sun W, ZhangB,Yu X, Zhuang C, Li X, Sun J, Xing Y, Xiu Z, Dong Y*, Oroxin A fromOroxylumindicumprevents the progression from prediabetes to diabetes instreptozotocin and high-fat-diet induced mice, Phytomedicine,2018, 38:24-34.

6.Sun W, ZhangB,Zheng H, Zhuang C, Li X, Lu X, Quan C, Dong Y*, Zheng Z*, Xiu Z,Trivaric Acid, a New Inhibitor of PTP1b with Potent Beneficial Effecton Diabetes. LifeSciences,2016, 169:52-64.

7.Sun W, Sun J, ZhangB,Xing Y, Yu X, Li X, Xiu Z, Dong Y*, Baicalein Improves InsulinResistance Via Regulating SOCS3 and Enhances the Effect of Acarboseon Diabetes Prevention. Journalof Functional Foods,2017, 37:339-353.

8.Sun W, Sang Y, ZhangB,Yu X, Xu Q, Xiu Z, Yuesheng Dong*. Synergistic Effects of Acarboseand an OroxylumindicumSeed Extract in Streptozotocin and High-Fat-Diet Induced PrediabeticMice. Biomedicine& Pharmacotherapy,2017, 87:160-70.

9.Sun W, Zhuang C, Li X, ZhangB,Lu X, Zheng Z, Dong Y*. Varic Acid Analogues from Fungus as PTP1BInhibitors: Biological Evaluation and Structure–activityRelationships. Bioorganic& Medicinal Chemistry Letters,2017, 27:3382–3385.

专利：

1.董悦生，张博崴，孙文龙，桑元斌，于晓霞，修志龙.一种具有α-糖苷酶抑制活性的药物组合物及其应用，专利号：ZL201510081001.8

2.董悦生，张博崴，文琛，孙文龙，余娜，修志龙.具有α-淀粉酶协同抑制活性的组合物，申请号：201710466865.0

3.董悦生，孙文龙，张博崴，桑元斌，于晓霞，徐亲民，修志龙.一种改善高脂高糖饮食并发症的药物组合物及其应用，专利号：ZL201510079721.0

4.董悦生，桑元斌，张博崴，徐亲民，修志龙.一种预防糖尿病药物组合物及其应用，专利号：ZL201210159072.1

5.董悦生，桑元斌，张博崴，徐亲民，修志龙.一种降糖药物组合物及其应用,中国发明专利，专利号：ZL201210158501.3

6.董悦生，孙文龙、张博崴、李夏、修志龙.预防或治疗前驱糖尿病的药物和药物组合物，中国发明专利，申请号：201710619663.5

7.董悦生，孙文龙、张博崴、李夏、修志龙.一种预防或治疗脂肪肝的药物及其应用，中国发明专利，申请号：201710625595.3

五、荣誉和奖励

2018年，辽宁省普通高等学校优秀毕业生

2017年，博士研究生国家奖学金

六、联系方式

1.通讯地址：天津市南开区同砚路38号

2.E-mail：bwzhang@nankai.edu.cn