分子遗传研究室研究成果

2017-06-23

近年发表主要文章:
1. Sun W, Shen WW, Yang S, Hu F, Gao Y, Qiao YH, Zhu TH. Homo-binding character of LMO2 isoforms and their both synergic and antagonistic functions in regulating hematopoietic cells. J Biomed Sci. 2010;17(1):22.
2. Sun W, Shen W, Yang S, Hu F, Li H, Zhu TH. miR-223 and miR-142 attenuate hematopoietic cell proliferation, and miR-223 positively regulates miR-142 through LMO2 isoforms and CEBP-β. Cell Res. 2010;20(10):1158-69.
3. Sun W, Yang S, Shen W, Li H, Gao Y, Zhu TH. Identification of DeltaEF1 as a novel target that negatively regulated by LMO2 in T cell leukemia. Eur J Haematol. 2010; 85(6): 508-519.
4. Hu F, Wang C, Du J, Sun W, Yan J, Mi D, Zhang J, Qiao Y, Zhu T, Yang S. (2010) deltaEF1 promotes breast cancer cell proliferation through down-regulating p21 expression. Biochimica et Biophysica Acta 1802: 301-312.
5. Yan JD, Yang S, Zhang J, Zhai CL, Zhu TH. (2009) BMP6 attenuates oxidant injury in HK-2 cells via Smad-dependent HO-1 induction. Free Radical Biology & Medicine. 46: 1275-1282.
6. Du J, Yang S, An Di, Hu Fen, Yuan Wei, Zhai Chunli, Zhu TH. (2009) BMP-6 Inhibits MicroRNA-21 Expression through repressing delta-EF1 and AP-1 in breast cancer. Cell Research. 19: 487-496.
7. Yang S, Du J Wang ZQ, Yan JD, Yuan W, Zhang J, Zhu TH. (2009) Dual Mechanism of EF1 Expression Regulated by Bone Morphogenetic Protein-6 in Breast Cancer. The international journal of biochemistry and cell biology 41: 853-861.
8. Yuan W, Sun W, Yang S, Du J, Zhai C, Wang Z, Zhang J, Zhu T. (2008) Down regulation of MicroRNA142 by proto-oncogene LMO2 and its co-factors in Hematopoiesis. Leukemia 22: 1067-1071.
9. Yang S, Du J, Wang ZQ, Yuan W, Qiao YH, Zhang M, Zhang J, Yin J, Gao SY, Cui YK and Zhu TH. (2007) BMP-6 promotes E-cadherin expression through repressing deltaEF1 in breast cancer cells. BMC Cancer 7:211.
10. Qing Wang, Di Chen, Ming Zhang, Xu Wang, Shuang Yang, Wei Yuan and Tianhui Zhu. A novel LMO2 transcript, regulated by GATA-1 and PU.1, encodes an antagonist of LMO2. Leukemia, 21,1015-1025, 2007
11. Qing Wang, Siaochao Wei,;Tianhui Zhu; MingZhang; RunShen;LianpingXing, Regis.J.O’keefe and DiChen:Bone Morphogengetic Protein 2 activates Smad6 gene transcription through Bone-specific Transcription Factor Runs2. The Journal of Biological Chemistry 82(14) 10742-10748, 2007
12. Zhang Ming, Wang qing, Yuan wei, Yang shuang, Wang xu, Du jun, Yan Ji-dong Zhu Tian-hui : Epigenetic regulation of bone morphogenetic protein -6 gene expression in breast cancer cells. “Journal of steroid biochemistry and molecular biology. 105(2007)91-97
13. Du J, Zhu YJ, Chen XY, Fei ZJ, Yang S, Yuan W, Zhang J and Zhu TH. (2007) Protective effect of Bone Morphgenetic Protein-6 on neurons from H2O2 injury. Brain Research 1163:10-20.
14. Yang S, Zhao L, Yang JH, Chai DG, Zhang M, Zhang J, Ji XH, Zhu TH. (2007) DeltaEF1 represses BMP-2-induced osteoblast differentiation of C2C12 cells. Journal of Biomedical Science 14: 663-679.
15. Zhang M, Wang Q, Yuan W, Yang S, Wang X, Du J, Yan JD, Zhu TH. (2007) Epigenetic Regulation of Bone morphogenetic protein-6 Gene Expression in breast cancer cells. Journal of Steroid Biochemistry and Molecular Biology 105:91-97.