一、教育经历：

2003/9 - 2008/7，中国医学科学院北京协和医科大学，细胞生物学，博士

1996/9 - 2001/7，中国药科大学，药理学，学士

二、科研与学术工作经历：

2021/1 - 现在，   南开大学，医学院，研究员

2016/7 - 2020/12，南开大学，医学院，副研究员

2012/1– 2016/07，南开大学，生命科学学院，副研究员

2013/8 - 2014/08，耶鲁大学，遗传系，访问学者

2008/7 - 2011/12，南开大学，生命科学学院，讲师

三、研究方向：干细胞生物学

（一）研究领域

1、胚胎干细胞全能性维持分子机制

2、干细胞抵御机体衰老策略及机制

3、干细胞分化调控及体内示踪

（二）科研项目

1.  国家自然科学基金：32070860，Dppa3在胚胎干细胞多能性维持及DNA甲基化调控中的作用机制，2021.1-2024.12 主持

2.  国家自然科学基金：31771636，Lin28a调控ES细胞naïve-primed状态转变机制研究，2018.1-2021.12 主持

3.  国家自然科学基金：31000651，印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究，2011.1-2013.12，主持       

4.  天津市自然科学基金重点项目：14JCZDJC35200，先天性角化不良发病机制探究， 2014.3-2017.4，主持

5.  天津市自然科学基金面上项目：18JCYBJC24400,Lin28在ES细胞多能性调控及早期分化中的作用机制，2018.4-2021.3，主持

6.  中央高校基本科研业务经费：63191158，利用ES外泌体增强成体干细胞治疗作用初探，2019.01-2019.12，主持

7.  中央高校基本科研业务费专项资金：印迹基因H19表达调控与孤雌胚胎干细胞多能性关系研究， 2010.6-2012.5，主持

8.  中国人民解放军总医院肾脏疾病国家重点实验室开放课题：KF-19-07, MSC联合ES-EV在急性肾损伤治疗中的作用, 2020.1-2021.12,主持

9.  国家重大科学研究计划：端粒相关蛋白在基因表达调控及细胞分化中的作用， 2012.1-2016.8，南开大学唯一参与人

10.国家重点研发计划：2017YFA0103201, 不同胚层来源器官损伤后再生细胞命运及调控生理性修复的研究，2017.1-2021.8，参与

11.国家重大科学研究计划：2009CB941000，猪诱导多能干细胞（iPS）及其分化发育研究， 2009.1-2013.8，参与

12.天津市自然科学基金重点项目：14JCZDJC35200端粒相关蛋白在多能性干细胞中的作用及调控，2012.4-2015.3，参与

13.国际合作项目：单细胞技术研究肿瘤干细胞标志和新药研发， 2013.1-2016.12，参与

14.国家转基因重大专项：2009ZX08006-010B，利用生殖系多能性干细胞构建高效的培育优良品种猪和转基因猪的新技术平台，2009.1-2010.12，研究骨干

15.国家自然科学基金重点项目：31430052端粒再生与卵巢功能重建，2015.1-2018.12，研究骨干

四、学术兼职

1、中国生物医学工程学会干细胞工程技术分会委员

2、国家自然科学基金通讯评审专家

3、教育部学位中心学位论文评审专家

4、河北省科技计划项目网络评审专家

五、发表文章：

[1]     Hui Sang, Dan Wang, Shuang Zhao, Jinxin Zhang, Yan Zhang, Jia Xu, Xiaoniao Chen, Yan Nie, Kaiyue Zhang, Shuaiqiang Zhang, Yuebing Wang, Na Wang, Fengxia Ma, Ling Shuai, Zongjin Li, NaLiu*. Dppa3 is critical for Lin28a-regulated ES cells naïve‒primed state conversion. J Mol Cell Biol. 2019 Jun 1; 11(6):474-488. Corresponding Author

[2]     Yan Zhang, Jia Xu, Siying Liu, Meikuang Lim, Shuang Zhao, Kaige Cui, Kaiyue Zhang, Lingling Wang, Qian Ji, Zhongchao Han, Deling Kong, Zongjin Li, Na Liu*. Embryonic stem cell-derived extracellular vesicles enhance the therapeutic effect of mesenchymal stem cells. Theranostics, 2019; 9(23):6976-6990. Corresponding Author

[3]     Na Liu^#, Yu Yin^#, Haiying Wang^#, Zhongcheng Zhou, Xiaoyan Sheng, Haifeng Fu, Renpeng Guo, Hua Wang, Jiao Yang, Peng Gong, Wen Ning, Zhenyu Ju, Yifei Liu*, Lin Liu*. Telomere dysfunction impairs epidermal stem cell specification and differentiation by disrupting BMP/pSmad/P63 signaling. PLoS Genet. 2019; 15(9): e1008368. First Author

[4]     Dan J^#, Liu Y^#, Liu N^#, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A*, Liu L*. Rif1 maintains telomere length homeostasis of ESCs by mediating heterochromatin silencing. Dev Cell. 2014 Apr 14;29(1):7-19. First Author

[5]     Lu Yu, Siying Liu, Chen Wang, Chuanyu Zhang, Yajie Wen, Kaiyue Zhang, Shang Chen, Haoyan Huang, Yue Liu, Lingling Wu, Zhongchao Han, Xiangmei Chen*, Zongjin Li*, Na Liu*. Embryonic stem cell-derived extracellular vesicles promote the recovery of kidney injury. Stem Cell Res Ther. 2021 Jul 2; 12(1):379. Corresponding Author

[6]     Wang D, Sang H, Zhang K, Nie Y, Zhao S, Zhang Y, He N, Wang Y, Xu Y, Xie X, Li Z, Liu N*. Stat3 phosphorylation is required for embryonic stem cells ground state maintenance in 2i culture media. Oncotarget. 2017 May 9;8(19):31227-31237. Corresponding Author

[7]     Yu Yin^#, Na Liu^#, Xiaoying Ye, Renpeng Guo, Jie Hao, Fang Wang, Lin Liu. Telomere elongation in parthenogenetic stem cells. Protein ＆Cell. 2014 5(1):8-11 First Author

[8]     Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R, Liu N*, Liu L*. , Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells. Current Molecular Medicine, 2014;14(6):737-48. Corresponding Author

[9]     Zhenrong Zhao, Xinghua Pan, Lin Liu and Na Liu*. Telomere Length Maintenance, Shortening, and Lengthening. J Cell Physiol. 2014; 229(10):1323-9. Corresponding Author

[10]  Na Liu*, Lin Liu & Xinghua Pan. Single‑cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos. Cell. Mol. Life Sci. (2014) 71:2707–2715 First Author and Corresponding Author

[11]  Shuang Zhao, Jia Xu, Siying Liu, Kaige Cui, Zongjin Li, NaLiu*.Dppa3 in pluripotency maintenance of ES cells and early embryogenesis. Journal of Cellular Biochemistry, 2019 Apr;120(4):4794-4799. Corresponding Author

[12]  Yan Zhang, Dan Wang, Jia Xu, Yuebing Wang, Fengxia Ma, Zongjin Li, Na Liu*. Stat3 activation is critical for pluripotency maintenance. J Cell Physiol. 2019 Feb;234(2):1044-1051. Corresponding Author

[13]  Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L. Genome-wide Gene Expression Profiling Reveals Aberrant MAPK and Wnt Signaling Pathways Associated with Early Parthenogenesis. J Mol Cell Biol. 2010, 2(6):333-344. First Author

[14]  Nie Y, Zhang K, Zhang S, Wang D, Han Z, Che Y, Kong D, Zhao Q, Han Z, He ZX, Liu N*, Ma F*, Li Z*.Nitric oxide releasing hydrogel promotes endothelial differentiation of mouse embryonic stem cells.Acta Biomater. 2017 Nov;63:190-199.  Corresponding Author

[15]  Ningning He, Guowei Feng, Yang Li, Yang Xu, Xiaoyan Xie, Hui Wang, Yuebing Wang, Lailiang Ou, Xuetao Pei, Na Liu*, and Zongjin Li*. Embryonic stem cell preconditioned microenvironment suppresses tumorigenic properties in breast cancer. Stem Cell Res Ther. 2016, 7(1):95 Corresponding Author

[16]  Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC. Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.J Cell Biochem. 2009, 106(6):1041-1047.First Author

[17]  Liu N, Feng X, Fang Z, Ma F, Lu S, Lu M, Han Z. Identification of Genes Regulated by Nanog Which Is Involved In ES Cells Pluripotency and Early Differentiation. J Cell Biochem.2008, 104(6):2348-2362.First Author

[18]  Liu N, Lu M, Tian X, Han Z.Molecular mechanisms involved in self-renewal and pluripotency of embryonic stem cells. J Cell Physiol. 2007, 211(2):279-286.First Author

[19]  Liu N, Lu M. The signal transduction pathways and molecules for ES cells self-renewal, Chinese Science Bulletin. 2005, 50(8):721-726.First Author

[20]  Na Liu,  Xin Qi, Zhibo Han, Lu Liang, Deling Kong, Zhongchao Han, Shihua Zhao, Zuo-Xiang He, and Zongjin Li*. Bone Marrow Is a Reservoir for Cardiac Resident Stem Cells. Sci Rep. 2016, 6:28739. First Author

[21]  Chen Wang, Guoyun Li, Kaige Cui, Zihan Chai, Ziyu Huang, Yue Liu, Shang Chen, Haoyan Huang, Kaiyue Zhang, Zhibo Han, Yuhao Li, Guangli Yu, Zhong-Chao Han, Na Liu*, Zongjin Li*. Sulfated glycosaminoglycans in decellularized placenta matrix as critical regulators for cutaneous wound healing. Acta Biomater. 2021 Mar 1;122:199-210. Corresponding Author

[22]  Liang L, Yue Z, Du W, Li Y, Tao H, Wang D, Wang R, Huang Z, He N, Xie X, Han Z, Liu N*, Li Z*. Molecular Imaging of Inducible VEGF Expression and Tumor Progression in a Breast Cancer Model. Cell Physiol Biochem. 2017 May 25;42(1):407-415. Corresponding Author

[23]  Huifang Li, Haoyan Huang, Xiaoniao Chen, Shang Chen, Lu Yu, Chen Wang, Yue Liu, Kaiyue Zhang, Lingling Wu, Zhong-Chao Han, Na Liu*, Jie Wu*, Zongjin Li*. The delivery of hsa-miR-11401 by extracellular vesicles can relieve doxorubicin-induced mesenchymal stem cell apoptosis. Stem Cell Res Ther. 2021 Jan 22;12(1):77. Corresponding Author

[24]  Anan Huang, Danni Liu, Xin Qi, Zhiwei Yue, Hongmei Cao, Kaiyue Zhang, Xudan Lei, Youzhi Wang, Deling Kong, Jie Gao, Zongjin Li, NaLiu*, Yuebing Wang*. Self-Assembled GFFYK Peptide Hydrogel Enhances the Therapeutic Efficacy of Mesenchymal Stem Cells in a Mouse Hindlimb Ischemia Model. Acta Biomater. 2019 Feb;85:94-105. doi: 10.1016/j.actbio.2018.12.015. Corresponding Author

[25]  Cao X, Duan L, Hou H, Liu Y, Chen S, Zhang S, Liu Y, Wang C, Qi X, Liu N, Han Z, Zhang D, Han ZC, Guo Z, Zhao Q, Li Z. IGF-1C hydrogel improves the therapeutic effects of MSCs on colitis in mice through PGE2-mediated M2 macrophage polarization. Theranostics. 2020. DOI: 10.7150/thno.45434 PMID: 32685014

[26]  Kaiyue Zhang, Xiangnan Zhao, Xiaoniao Chen, Yongzhen Wei, Wei Du, Yuebing Wang, Linan Liu, Weian Zhao, Zhibo Han, Deling Kong, Qiang Zhao, Zhikun Guo, Zhongchao Han, Na Liu, Fengxia Ma *, Zongjin Li*. Enhanced Therapeutic Effects of Mesenchymal Stem Cell-Derived Exosomes with an Injectable Hydrogel for Hindlimb Ischemia Treatment. ACS Appl Mater Interfaces. 2018 Sep 12;10(36):30081-30091..

[27]  He N, Chen X, Wang D, Xu K, Wu L, Liu Y, Tao H, Zhao Q, Cao X, Li Y, Liu N, Qi X, Han Z, Kong D, Yang J, Li Z. VE-Cadherin regulates the self-renewal of mouse embryonic stem cells via LIF/Stat3 signaling pathway. Biomaterials. 2017 Dec 16;158:34-43.

[28]  Liu Y, Song B, Wei Y, Chen F, Chi Y, Fan H, Liu N, Li Z, Han Z, Ma F.Exosomes from mesenchymal stromal cells enhance imatinib-induced apoptosis in human leukemia cells via activation of caspase signaling pathway. Cytotherapy. 2017 Dec 18. pii: S1465-3249(17)30733-8.

[29]  Wang R, Zhang K, Tao H, Du W, Wang D, Huang Z, Zhou M, Xu Y, Wang Y, Liu N, Wang H, Li Z. Molecular Imaging of Tumor Angiogenesis and Therapeutic Effects with Dual Bioluminescence. Curr Pharm Biotechnol.  2017;18(5):422-428.

[30]  Du W, Zhang K, Zhang S, Wang R, Nie Y, Tao H, Han Z, Liang L, Wang D, Liu J, Liu N, Han Z, Kong D, Zhao Q, Li Z. Enhanced proangiogenic potential of mesenchymal stem cell-derived exosomes stimulated by a nitric oxide releasing polymer. Biomaterials. 2017 Jul;133:70-81.

[31]  Liu K, Mao J, Song L, Fan A, Zhang S, Wang J, Fan N, Liu N, Ye X, Fu H, Zhou Z, Wang Y, Wei H, Liu Z, Li Z, Lai L, Wang X, Liu L. DNA repair and replication links to pluripotency and differentiation capacity of pig iPS cells. PLoS One. 2017 Mar 2;12(3):e0173047.

[32]  Song X, Liu D, Cui J, Zhou M, Wang H, Liu N, Qi X, Li Z. Identification of Stem-Like Cells in Atrial Myxoma by Markers CD44, CD19, and CD45. Stem Cells Int. 2016;2016:2059584.

[33]  Guowei Feng, Jimin Zhang, Yang Li, Yan Nie, Dashuai Zhu, Ran Wang, Jianfeng Liu, Jie Gao, Na Liu, Ningning He, Wei Du, Hongyan Tao, Yongzhe Che, Yong Xu, Deling Kong, Qiang Zhao, and Zongjin Li*. IGF-1 C Domain-Modified Hydrogel Enhances Cell Therapy for AKI. J Am Soc Nephrol. 2016, 27(8):2357-69. 

[34]  Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L. Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015, 6(2):152-6.

[35]  Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, Yang D, Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, Wang Q, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L. Piglets cloned from induced pluripotent stem cells. Cell Res. 2013, 23(1):162-6.

[36]  Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L. No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells. 2013 31(11):2538-50.

[37]  Ji G, Liu K, Okuka M, Liu N, Liu L. Association of telomere instability with senescence of porcine cells. BMC Cell Biol. 2012 Dec 15; 13:36.

[38]  Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N, Liu L. Influences of lamin A levels on induction of pluripotent stem cells. Biol Open. 2012, 1(11):1118-27.

[39]  Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D. Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovasc Res. 2012, 97(2):208-18.

[40]  Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L.Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction. 2012; 27(5): 1411-1420.

[41]  Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.Cell Research. 2012; 22(4): 757-768.

[42]  Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L*. Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Research. 2011, 21(5):779-92.

[43]  Fang ZH, Dong CL, Chen Z, Zhou B, Liu N, Lan HF, Liang L, Liao WB, Zhang L, Han ZC. Transcriptional regulation of survivin by c-Myc in BCR/ABL-transformed cells: implications in anti-leukaemic strategy.J Cell Mol Med. 2009 13(8B):2039-52.

[44]  Feng XM, Liu N, Yang SG, Hu LY, Chen XL, Fang ZH, Ren Q, Lu SH, Liu B, Han ZC.Regulation of the classⅡ and classⅠMHC pathways in human THP-1 monocytic cells by interleukin-27. Biochem Biophys Res Commun. 2008 14;367(3):553-9.

[45]  Feng XM, Chen XL, Liu N, Chen Z, Zhou YL, Han ZB, Zhang L, Han ZC. Interleukin-27 upregulates major histocompatibility complex class Ⅱ expression in primary human endoghelial cells through induction of major histocompatibility complex class Ⅱ trasactivator. Hum Immunol. 2007 68(12):965-72.

Books and Chapters:

[46]  Yin Y, Liu N, Keefe D, and Liu L.Parthenogenetic activation-induced pluripotent stem cells and potential applications. Stem Cells and Cancer Stem Cells. Volume 8. Hayat, MA (edt.) Springer, 2012, 235-246.

[47]  Yan Nie, Shuaiqiang Zhang, Na Liu,  Zongjin Li, Extracellular Matrix Enhances Therapeutic Effects of Stem Cells in Regenerative Medicine.  Composition and Function of the Extracellular Matrix in the Human Body. INTECH, 2016

[48]  Yan Zhang, Zongjin Li, and Na Liu*，The Stemness of Perinatal Stem Cell，Perinatal Stem CellsISBN 978-981-13-2702-5, ISBN 978-981-13-2703-2 (eBook)Springer Nature Singapore Pte Ltd. 2019

六、讲授课程
1．细胞生物学 (本科生，主讲)
2．干细胞与再生医学 （硕士研究生，主讲）

3. 干细胞与再生医学前沿 （博士研究生）

七、荣誉和奖励
1．2012年南开大学教学成果奖 二等奖

2．2016年南开大学青年教师教学基本功竞赛 二等奖

3．2016年天津市青年教师教学基本功竞赛 三等奖

八、联系方式
1． 通讯地址：天津市卫津路94号南开大学医学院304
2． E-mail：liuna@nankai.edu.cn