姓名： 刘菲菲

职称： 副教授

一、教育经历

2008– 2011美国哈佛大学医学院, MGH麻省总医院，博士后
2002– 2007美国杜克大学，免疫学博士
2002– 2007美国杜克大学，细胞分子生物学专业
1995– 2002南开大学 医学院，七年制临床医学本硕连读

二、工作经历

2011.11-南开大学 医学院，副教授

三、研究方向（包括承担课题项目）

1.髓系发生和白血病的发生机制 Molecular mechanism of myelopoiesis and leukemogenesis

2.髓系白血病的治疗 Molecular Therapy of AML

3.血液免疫系统的分化和调控 Differentiation of hematopoiesis and immune system

承担课题项目：

1国家自然科学基金青年基金：B细胞骨髓免疫耐受机制－抗原非依赖性IgH和Igkappa的V(D)J基因重排（2013-2015）

2南开大学校内基金特别资助类：Ikaros调控急性T淋巴细胞白血病的功能 (2012－2014)

3天津市自然科学基金青年项目：B细胞骨髓免疫耐受机制-receptor editing的分子机制（2013-2016）

4南开大学高等学校博士学科点专项科研基金：B细胞受体编辑的分子机制 （2012-2015）

四、发表论文

1. Li Y, Liu Y, Liu C, Liu F, Dou D, Zheng W, Liu W, Liu F. Role of a non-canonical splice variant of the Helios gene in the differentiation of acute lymphoblastic leukemic T cells. Oncology Letters. 2018 May; 15 (5):6957-6966.

2. Zhao S, Liu W, Li Y, Liu P, Li S, Dou D, Wang Y, Yang R, Xiang R, Liu F. Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia. PLoS One. 2016 Sep 28;11(9):e0163328. doi: 10.1371/journal.pone.0163328.

3. Li S, Liu W, Li Y, Zhao S, Liu C, Hu M, Yue W, Liu Y, Wang Y, Yang R, Xiang R, Liu F. Contribution of secondary Igkappa rearrangement to primary immunoglobulin repertoire diversification. Molecular Immunology. 2016 Sep 22;78:193-206. doi: 10.1016/j.molimm.2016.09.006.

4.Cao S, Su X, Zeng B, Yan H, Huang Y, Wang E, Yun H, Zhang Y, Liu F, Li W, Wei H, Che Y, Yang R. The Gut Epithelial Receptor LRRC19 Promotes the Recruitment of Immune Cells and Gut Inflammation.Cell Report. 2016 Feb 2;14(4):695-707. doi: 10.1016/j.celrep.2015.12.070.

5.Su X, Yan H, Huang Y, Yun H, Zeng B, Wang E, Liu Y, Zhang Y, Liu F, Che Y, Zhang Z, Yang R. Expression of FABP4, adipsin and adiponectin in Paneth cells is modulated by gut Lactobacillus.Science Report. 2015 Dec 21;5:18588. doi: 10.1038/srep18588.

6.Su X, Min S, Cao S, Yan H, Zhao Y, Li H, Chai L, Mei S, Yang J, Zhang Y, Zhang Z, Liu F, Sun W, Che Y, Yang R. LRRC19 expressed in the kidney induces TRAF2/6-mediated signals to prevent infection by uropathogenic bacteria.Nature Commun. 2014 Jul 16;5:4434. doi: 10.1038/ncomms5434.

7. Jiangwen Zhang, Audrey F Jackson, Taku Naito, Marei Dose, John Seavitt, Feifei Liu, Elizabeth J Heller, Mariko Kashiwagi, Toshimi Yoshida, Fotini Gounari, Howard T Petrie & Katia Georgopoulos. Harnessing of the nucleosome-remodeling-deacetylase complex controls lymphocyte development and prevents leukemogenesis. Nature Immunology. 2011 Nov. 13;13(1):86-94 (Fourth author)

8.Pablo Gómez-del Arco, Mariko Kashiwagi, Audrey Jackson, Taku Naito, Jiangwen Zhang, Feifei Liu, Barbara Kee, Marc Vooijs, Freddy Radtke, Juan Miguel Redondo and Katia Georgopoulos. Alternative Promoter Usage at the Notch1 Locus Supports Ligand-Independent Signaling in T Cell Development and Leukemogenesis. Immunity. 2010 Nov; Vol. 33(5) p. 685 – 698. (Fourth author)

9.Marco Davila*, Feifei Liu*, Lindsay G. Cowell, Anne E. Lieberman, Emily Heikamp, Anjali Patel, Garnett Kelsoe. Multiple, conserved cryptic recombination signals in VH gene segments: detection of cleavage products only in pro-B cells. Journal of Experimental Medicine. 2007 Dec 24; Vol. 204, p3195-3208. (* co-first author) (sci impact factor 15.61)

五、讲授课程

1.本科生 医学免疫学

2.硕士生 医学免疫学

3.留学生 医学免疫学

六、荣誉和奖励

1.2006 - 2007 Duke Conference Travel Fellowship, Duke University

2.2006 Bernard Amos Research Award

3.2006 Certificate for professionalism and academic excellence
 The Graduate School, Duke University

七、联系方式

1． 通讯地址：天津市南开区卫津路94号

2． E-mail：liufeifei@nankai.edu.cn