姓名： 李董
职称： 副教授

一、教育经历
1. 1992年9月~1996年7月：南开大学生命科学学院，生物化学和分子生物学系专业，理学学士，
2. 2000年9月~2003年9月：中国医学科学院中国协和医科大学血液学研究所，病理生理专业，医学硕士
3. 2004年9月~2007年7月：南开大学生命科学学院，生物信息学专业，理学博士

二、工作经历
1. 1996年7月~2000年6月：中国医学科学院中国协和医科大学血液学研究所实验血液学国家重点实验室，实习研究员
2. 2000年9月~2002年6月：实验血液学国家重点实验室，学术秘书，
3. 2003年7月~2004年9月：中国医学科学院中国协和医科大学血液学研究所实验血液学国家重点实验室，助理研究员
4. 2007年7月~2009年1月: 南开大学医学院，讲师
5. 2009年1月—南开大学医学院，副教授
6. 2014年2月~ 2015年8月：加拿大卡尔加里大学卡明医学院里宾心血管研究所，生物化学系，访问学者

三、研究方向（包括承担课题项目）
1 心血管病机制研究，尤其是动脉粥样硬化的发病机制及治疗
2 血管功能的调节及药理学机制

承担课题项目：
1. 1996年~2000年：国家“863”计划：应用可溶性受体进行恶性肿瘤导向治疗的实验研究，参加
2. 2001年~2003年： “863”计划：IL6/IL2融合蛋白治疗肿瘤的临床前研究，主要参加
3. 2008年月~2010年:国家自然科学基金面上项目：四磷酸脲腺苷对血管平滑肌及动脉粥样硬化的作用，主要参加
4. 2008年-2011年，天津市基金重点项目：雌激素代谢产物2ME治疗动脉粥样硬化的研究，主要参加
5. 2010年-2013年，天津市应用基础及前沿技术研究计划，合作方主持
6. 2010年，教育部直属高校聘请外国文教专家年度计划，海外名师项目（哈佛大学王大之教授），主持/项目执行人，
7. 2011年-2015年：国家重大科学研究计划项目（973，发育与生殖研究领域），子课题:肾血管球形成和足细胞发育的分子调控机制，参加

四、学术兼职
1. 中华医学会，自从1999年
2. 中国生物物理学会，自从2006年

五、发表论文
1. Dong Li, Jie Gao, Xi Tan, Feng Gan, Michael P. Walsh, Yu Gui, Xi-long Zheng, MCP-1 inhibits vascular contractility of in mouse aorta. Manuscript in preparation.
2. Pavneet Singh, Dong Li, Yu Gui, Xi-Long Zheng, Atrogin-1 ubiquitinates myocardin forproteosomal degradation with increased transcriptional activity, J Cell Physiol. 2016.
3. Gui Y, Shi Z, Wang Z, Li JJ, Xu C, Tian R, Song X, Walsh MP, Li D, Gao J, Zheng XL TheGPER agonist G-1 induces mitotic arrest and apoptosis in human vascular smooth muscle cells independent of GPER. J Cell Physiol. 2015 Apr;230(4):885-95.
4. Mengdan Liu, Wenlei Zhao, Lijuan Xu, Meiyi Tian, Yanran Tian, Wensu Yuan, Dong Li*, AICAR inhibits porcine coronary artery contraction induced by acetylcholine, The 15th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).
5. Wensu Yuan, Zengyong Wang, Jingjing Li, Lijuan Xu, Dong Li*, Estrogen Metabolite 2ME Prevents Hypertension in Hypertensive Rats. The 15th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).
6. Ruijuan Tian, Zengyong Wang, Xinxing Song, Jingjing Li, Dong Li*，G-1 Inhibits Proliferation of Vascular Smooth Muscle Cells and Prevents Neointima Formation after Vessel Injury，The 15th Scientific Annual Congress of Chinese Society of Cardiology (CSC 2013, Tianjin).
7. Yuan Wensu, Xu Lijuan, Liu Mengdan, Wang Yuebing, Li Dong*, The Different Contraction between Rat Gastric Longitudinal and Circular Smooth Muscle Induced by Extracellular Nucleotides, Chinese Journal of Applied Physiology, (1)14-17，2014.
8. Yuan W, Wang Z, Li J, Li D, Liu D, Bai G, Walsh MP, Gui Y, Zheng XL. Uridine adenosine tetraphosphate induces contraction of circular and longitudinal gastric smooth muscle by distinct signaling pathways. IUBMB Life. 65(7):623-32. 2013.
9. Tian Ruijuan, Wang Lifeng, Xu Lijuan, Wang Yuebing, Li Yang, Shi Yanrong, Zhu Yinjun, Lin Wanjun, Li Dong*, G-protein-coupled estrogen receptor-30 inhibit the proliferation of human uterine leiomyoma, Acta Scientiarum Naturalium Universitatis Nankaiensis ( Science Edition), 47(3):16-21, 2013
10. Yuan W, Yu Y, Li J, Singh P, Li D, Gui Y, Zheng XL., Estrogen Metabolite 2-methoxyestradiol Prevents Hypertension in Deoxycorticosterone Acetate-salt Rats. Cardiovasc Drugs Ther. Feb; 27(1):17-22, 2013.
11. Tian R, Wang Z, Shi Z, Li D, Wang Y, Zhu Y, Lin W, Gui Y, Zheng XL. Differential expression of G-protein-coupled estrogen receptor-30 in human myometrial and uterine leiomyoma smooth muscle. Fertil Steril. Jan; 99(1):256-63. 2013.
12. Li H, Li J, Li Y, Singh P, Cao L, Xu LJ, Li D, Wang Y, Xie Z, Gui Y, Zheng XL. Sonic hedgehog promotes autophagy of vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. Dec 1; 303(11):H1319-31. 2012.
13. Li J, Jiang J, Yin H, Wang L, Tian R, Li H, Wang Z, Li D, Wang Y, Gui Y, Walsh MP, Zheng XL. Atorvastatin inhibits myocardin expression in vascular smooth muscle cells. Hypertension. Jul; 60(1):145-53. 2012.
14. Zheng W, Wang Z, Song L, Zhao Q, Zhang J, Li D, Wang S, Han J, Zheng XL, Yang Z, Kong D. Endothelialization and patency of RGD-functionalized vascular grafts in a rabbit carotid artery model. Biomaterials. Apr; 33(10):2880-91. 2012.
15. Du F, Wang H, Zhao W, Li D, Kong D, Yang J, Zhang Y. Gradient nanofibrous chitosan/poly ?-caprolactone scaffolds as extracellular microenvironments for vascular tissue engineering. Biomaterials. Jan; 33(3):762-70. 2012.
16. Liang Cao, Jingjing Li, Dong Li Xilong Zheng, AICAR Inhibits Proliferation of Smooth Muscle Cells From Porcine Coronary Arteries, 2011 China-Canada Symposium in Atherosclerosis and Cardiovascular Disease （Sept 23-25, Beijing, 2011）
17. Ge Gao, Jing-Jing Li, Yuenan Li, Dong Li, Yuebing Wang, Lifeng Wang, Xiang D. Tang, Michael P. Walsh, Yu Gui, Xi-Long Zheng, Rapamycin inhibits hydrogen peroxide-induced loss of vascular contractility, Am J Physiol Heart Circ Physiol. 300: H1583-H1594. 2011.
18. Wang, Guosong; Zhang, Hengyi; Li, Dong; Wang, Puyue; *Liu, Yu, Characterisation and antiproliferative activity of irinotecan and sulphonatocalixarene inclusion complex SUPRAMOLECULAR CHEMISTRY, 23(6), pp 441-446, 2011.
19. Cui, L. H., Ren, Y. Y.,. Yin H., Li, D., and Zheng, X. L., increased expression of tuberin in human uterine leiomyoma. Fertility and Sterility; 95: 1805-8. 2011.
20. Wang K, Guo DS, Zhang HQ, Li D, Zheng XL, Liu Y. Highly effective binding of viologens by p-sulfonatocalixarenes for the treatment of viologen poisoning. Journal of Medicinal Chemistry; 52: 6402-12. 2009.
21. Li, D., Du, C. Y., Tang, X. J., Jin, Y. X., Lei, T., Yao, Y., Yang, Z., and Zhang, T., [Changes of heart rate variability and impairment of learning and memory induced by cerebral ichemia/reperfusion in rats.]. Sheng Li Xue Bao,. 59(1): p. 35-41. 2007.
22. Li, D., Jin, Y. X., Yang, Z., and Zhang, T., Analysis of Multifibre Renal Sympathetic Nerve Recordings. Lecture Notes in Computer Science. 3973: p. 734 - 739. 2006.
23. Li, D., Du, C. Y., Tang, X. J., Jin, Y. X., Lei, T., Yao, Y., Yang, Z., and Zhang, T., Effect on autonomic nervous system and learning and memory induced by cerebral ischemia/reperfusion in rats. Acta Biophsica Sinica, 2006. 22(supplement): p. 83.
24. Yang, Z. Q., Li, Y. N., Chen, F., Li, D., Zhang, Z. F., Liu, Y. X., Zheng, D. X., Wang, Y., and Shen, G. F., Expression of hsTRAIL in Chlamydomonas reinhardtii Chloroplast. Chinese Science Bulletin 2006. 51(12): p. 1400-1405.
25. Yuan, W. S., Zhao, Z. G., Li, D., and Li, J., [Biological characteristics and ability of supporting hematopoiesis of fetal bone marrow mesenchymal stem cells]. Shandong Medical Journal, 2005. 45(11): p. 31-32.
26. Song, J. M., Xu, D., Fan, E. J., Xu, S. R., Li, D., and Zhao, C. H., [Cyclin D2 expression in chronic myelogenous leukemia]. Zhong hua Xue Ye Xue Za Zhi, 2004. 25(2): p. 103-5.
27. Li, D., Yuan, W. S., Ma, X. T., Cai, H. G., Ming, Y., Li, J., and Zhao, R. C., High Density Fermentation and Purification of Recombinant Human IL-6/2 Fusion Protein. High Technology Letters, 2003. 45(11): p. 27-30.
28. Deng, W. M., Li, C. H., Liao, L. M., Ge, W., Li, D., Yuan, W. S., Zhao, Z. G., You, S. G., Deng, H. Y., and Zhao, R. C., adult bone marrow-derived pluripotential mesenchymal stem cells give rise to skin cells and regenerate skin tissue. Chinese Journal of Cell Biology, 2003. 25(02): p. 98-105.
29. Luo, S. Q., Zheng, D. X., Liu, Y. X., Li, D., Rao, Q., and Wu, K. f., Expression of srhM-CSFR in Insect Cells and Analysis of Binding Activity for its Ligand Chinese Journal of Biochemistry and Molecular Biology, 2000. 16(04): p. 443-447.
30. Shao, Y., Xiao, S., Li, D., Liu, Y. X., Liu, S. L., and Zheng, D. X., Molecular clone of CD2 cytoplasmic binding protein in human lymphocyte. Acta Academiae Medicinae Sinicae, 1999. 21(02).

六、讲授课程
1．生物化学，临床及口腔医学生二年级
2. 医学生物化学，临床医学二年级
3. 信号传导，研究生一年级
4．科研方法论，研究生一年级

七、联系方式
1． 通讯地址：天津市南开区卫津路94号
2． 电话：23501649
3． E-mail：lidong@nankai.edu.cn