肿瘤微环境与小分子药物临床研究室研究成果

2017-06-23

近年发表主要文章:
[1] C. Xu, J. Liu, L.C. Hsu, Y. Luo, R. Xiang, T.H. Chuang, Functional interaction of heat shock protein 90 and Beclin 1 modulates Toll-like receptor-mediated autophagy, FASEB J, 25 (2011) 2700-2710.
[2] R. Xiang, D. Liao, T. Cheng, H. Zhou, Q. Shi, T.S. Chuang, D. Markowitz, R.A. Reisfeld, Y. Luo, Downregulation of transcription factor SOX2 in cancer stem cells suppresses growth and metastasis of lung cancer, Br J Cancer, 104 (2011) 1410-1417.
[3] W. Su, M. Zhou, Y. Zheng, Y. Fan, L. Wang, Z. Han, D. Kong, R.C. Zhao, J.C. Wu, R. Xiang, Z. Li, Bioluminescence reporter gene imaging characterize human embryonic stem cell-derived teratoma formation, J Cell Biochem, 112 (2011) 840-848.
[4] D. Liao, Z. Liu, W.J. Wrasidlo, Y. Luo, G. Nguyen, T. Chen, R. Xiang, R.A. Reisfeld, Targeted Therapeutic Remodeling of the Tumor Microenvironment Improves an HER-2 DNA Vaccine and Prevents Recurrence in a Murine Breast Cancer Model, Cancer Res, 71 (2011) 5688-5696.
[5] D. Liao, Z. Liu, W. Wrasidlo, T. Chen, Y. Luo, R. Xiang, R.A. Reisfeld, Synthetic enzyme inhibitor: a novel targeting ligand for nanotherapeutic drug delivery inhibiting tumor growth without systemic toxicity, Nanomedicine, (2011).
[6] X. Jia, X. Li, Y. Xu, S. Zhang, W. Mou, Y. Liu, D. Lv, C.H. Liu, X. Tan, R. Xiang, N. Li, SOX2 promotes tumorigenesis and increases the anti-apoptotic property of human prostate cancer cell, J Mol Cell Biol, 3 (2011) 230-238.
[7] J. Hu, K. Qin, Y. Zhang, J. Gong, N. Li, D. Lv, R. Xiang, X. Tan, Downregulation of transcription factor Oct4 induces an epithelial-to-mesenchymal transition via enhancement of Ca(2+) influx in breast cancer cells, Biochem Biophys Res Commun, 411 (2011) 786-791.
[8] J. Hao, D. Campagnolo, R. Liu, W. Piao, S. Shi, B. Hu, R. Xiang, Q. Zhou, T. Vollmer, L. Van Kaer, A. La Cava, F.D. Shi, Interleukin-2/interleukin-2 antibody therapy induces target organ natural killer cells that inhibit central nervous system inflammation, Ann Neurol, 69 (2011) 721-734.
[9] Q. Wang, H. Ni, L. Lan, X. Wei, R. Xiang, Y. Wang, Fra-1 protooncogene regulates IL-6 expression in macrophages and promotes the generation of M2d macrophages, Cell Res, 20 (2010) 701-712.
[10] Y.P. Luo, H. Zhou, J. Krueger, C. Kaplan, D. Liao, D. Markowitz, C. Liu, T. Chen, T.H. Chuang, R. Xiang, R.A. Reisfeld, The role of proto-oncogene Fra-1 in remodeling the tumor microenvironment in support of breast tumor cell invasion and progression, Oncogene, 29 (2010) 662-673.
[11] J. Liu, C. Xu, L.C. Hsu, Y. Luo, R. Xiang, T.H. Chuang, A five-amino-acid motif in the undefined region of the TLR8 ectodomain is required for species-specific ligand recognition, Mol Immunol, 47 (2010) 1083-1090.
[12] Y. Li, M. Jiang, W. Liu, L. Zhang, S. Zhang, X. Zhao, R. Xiang, Y. Liu, Loop-mediated isothermal amplification method targets to the phoP gene for detection of Yersinia enterocolitica, Mol Cell Probes, 24 (2010) 68-71.
[13] J. Hao, R. Liu, W. Piao, Q. Zhou, T.L. Vollmer, D.I. Campagnolo, R. Xiang, A. La Cava, L. Van Kaer, F.D. Shi, Central nervous system (CNS)-resident natural killer cells suppress Th17 responses and CNS autoimmune pathology, J Exp Med, 207 (2010) 1907-1921.
[14] W.Y. Zhang, F.Q. Xu, C.L. Shan, R. Xiang, L.H. Ye, X.D. Zhang, Gene expression profiles of human liver cells mediated by hepatitis B virus X protein, Acta Pharmacol Sin, 30 (2009) 424-434.
[15] D. Liao, Y. Luo, D. Markowitz, R. Xiang, R.A. Reisfeld, Cancer associated fibroblasts promote tumor growth and metastasis by modulating the tumor immune microenvironment in a 4T1 murine breast cancer model, PLoS One, 4 (2009) e7965.
[16] X. Li, S. Zhang, H. Zhang, L. Zhang, H. Tao, J. Yu, W. Zheng, C. Liu, D. Lu, R. Xiang, Y. Liu, A loop-mediated isothermal amplification method targets the phoP gene for the detection of Salmonella in food samples, Int J Food Microbiol, 133 (2009) 252-258.
[17] J. Lee, M. Hayashi, J.F. Lo, C. Fearns, W.M. Chu, Y. Luo, R. Xiang, T.H. Chuang, Nuclear factor kappaB (NF-kappaB) activation primes cells to a pro-inflammatory polarized response to a Toll-like receptor 7 (TLR7) agonist, Biochem J, 421 (2009) 301-310.
[18] Xiang R, Luo Y, Niethammer AG, Reisfeld RA. Oral DNA vaccines target the tumor vasculature and microenvironment and suppress tumor growth and metastasis. Immunol Rev. 2008 Apr;222:117-28. Review
[19]Schrama D, Voigt H, Eggert AO, Xiang R, Zhou H, Schumacher TN, Andersen MH, thor Straten P, Reisfeld RA, Becker JC.Immunological tumor destruction in a murine melanoma model by targeted LTalpha independent of secondary lymphoid tissue. Cancer Immunol Immunother. 2008 Jan;57(1):85-95. Epub 2007 Jun 29. PMID: 17605009
[20]Lewēn S, Zhou H, Hu HD, Cheng T, Markowitz D, Reisfeld RA, Xiang R, Luo Y.A Legumain-based minigene vaccine targets the tumor stroma and suppresses breast cancer growth and angiogenesis. Cancer Immunol Immunother. 2008 Apr;57(4):507-15. Epub 2007 Sep 5.
Schrama D, Voigt H, Eggert AO, Xiang R, Zhou H, Schumacher TN, Andersen MH, thor Straten [21]P, Reisfeld RA, Becker JC.Immunological tumor destruction in a murine melanoma model by targeted LTalpha independent of secondary lymphoid tissue. Cancer Immunol Immunother. 2008 Jan;57(1):85-95. Epub 2007 Jun 29. PMID: 17605009
[22] Zeng Y, Huebener N, Fest S, Weixler S, Schroeder U, Gaedicke G, Xiang R, Schramm A, Eggert A, Reisfeld RA, Lode HN. Fractalkine (CX3CL1)- and Interleukin-2-Enriched Neuroblastoma Microenvironment Induces Eradication of Metastases Mediated by T Cells and Natural Killer Cells. Cancer Res. 2007 Mar 1;67(5):2331-8.