姓名：张裕英

职称：副教授

一、教育经历

2003-2008  研究生   武汉大学   生命科学学院         生物化学与分子生物学

1999-2003  本科     武汉大学   化学与分子科学学院   应用化学

二、科研及工作经历

2017至今    副教授 硕士生导师   南开大学医学院

2014-2017    博士后              德国杜伊斯堡-埃森大学化学系

2011-2014    博士后              德国奥森纳布吕克大学生物系

2008-2010    助理研究员          浙江大学高分子系

三、研究方向

多功能纳米探针的设计与疾病诊断、细胞/组织多色光谱成像

四、主要科研项目

1) 等离激元光生物催化制氢研究，天津市自然科学基金项目，主持（2022-2025）

2) iRGD介导纳米载体靶向渗透小鼠乳腺癌组织的SERS成像分析，国家自然科学基金面上项目，主持 （2019-2022）

3) 乳腺癌病人血清外泌体表面蛋白的SERS检测研究，南开大学交叉融合科学基金， 主持 （2019）

4) 用于光动力与光高热联合治疗癌症的新型微胶囊的制备及作用机制研究，国家自然科学基金青年项目，主持（2010-2012）

五、代表性著作、论文情况

 论文：

1) Zedong Zhang, Chang Liu, Jianguo Dong, Aonan Zhu, Chunyan An, Dekun Wang, Xue Mi, Shijiing Yue, Xiaoyue Tan, Yuying Zhang*. Self-Referenced Au Nanoparticles-Coated Glass Wafers for In Situ SERS Monitoring of Cell Secretion. ACS sensors, 2024, 9 (8), 4154-4165.

2) Namhyun Choi, Yuying Zhang, Yuling Wang*, Sebastian Schlücker*. iSERS: from nanotag design to protein assays and ex vivo imaging. Chemical Society Reviews, 2024, 53, 6675-6693.

3) Chang Liu, Jianguo Dong, Zedong Zhang, Kexin Fu, Dekun Wang, Xue Mi, Shijing Yue, Xiaoyue Tan, Yuying Zhang*. Four-Color SERS Monitoring of Size-dependent Nanoparticle Delivery in the Same Tumor. Analytical Chemistry, 2023, 95, 13880-13888.

4) Zedong Zhang, Dekun Wang, Chang Liu, Jianguo Dong, Mengmeng Jiang, Xue Mi, Xiaoyue Tan, Yuying Zhang*. Penetration-then-growth enables label-free surface-enhanced Raman spectroscopic discrimination of fibrotic cells and kidney tissues. Sensors and Actuators B: Chemical, 2023, 392, 134103.

5) Xinxin Yuan, Xue Mi, Chang Liu, Zedong Zhang, Xianfeng Wei, Dekun Wang, Xiaoyue Tan, Rong Xiang, Wei Xie, Yuying Zhang*. Ultrasensitive iodide detection in biofluids based on hot electron-induced reduction of p-Nitrothiophenol on Au@Ag core-shell nanoparticles. Biosensors and Bioelectronics 2023, 235, 115365.

6) Xue Mi, Haiqiao Du, Xinmeng Guo, Yan Wu, Long Shen, Yukun Luo, Dekun Wang, Qiuyue Su, Rong Xiang, Shijing Yue, Songgu Wu, Junbo Gong, Zhuo Yang, Yuying Zhang*, Xiaoyue Tan*. Asparagine endopeptidase-targeted Ultrasound-responsive Nanobubbles Alleviate Tau Cleavage and Amyloid-beta Deposition in an Alzheimer's Disease Model. Acta Biomaterialia, 2022;141:388-97.

7) Xue Mi, Xinmeng Guo, Haiqiao Du, Min Han, Hong Liu, Yukun Luo, Dekun Wang, Rong Xiang, Shijing Yue, Yuying Zhang*, Xiaoyue Tan*. Combined legumain- and integrin-targeted nanobubbles for molecular ultrasound imaging of breast cancer. Nanomedicine: Nanotechnology, Biology, and Medicine, 2022;42:102533.

8) Zhang, Feng, Yang, Xian, Wang, Dan, Yu, Linfeng, Hu, Yanfang, Zhu, Aonan, Zhang, Cancan, Zheng, Yunxiang, Yin, Tailang*, Zhang, Yuying*, Xie, Wei. Reproducible fabrication of gold nanostar monolayers for surface-enhanced Raman spectroscopy‐based trace detection. Journal of Raman Spectroscopy, 2022, 53, 1227-1237.

9) Cancan Zhang, Yuying Zhang*, Wei Xie*. Plasmonic metal/semiconductor hybrid nanomaterials for solar to chemical energy conversion. Journal of Energy Chemistry, 2021, 63, 40-53.

10) Xiaojie Wang, Xinxin Yuan, Kexin Fu, Chang Liu, Lu Bai, Xinchao Wang, Xiaoyue Tan, Yuying Zhang*. Colorimetric analysis of extracellular vesicle surface proteins based on controlled growth of Au aptasensors. Analyst, 2020, 146(6): 2019-2028.

11) Kexin Fu, Xiaojie Wang, Xinxin Yuan, Dekun Wang, Xue Mi, Xiaoyue Tan, Yuying Zhang*. Size-Dependent Penetration of Gold Nanoprobes into Fixed Cells. ACS Omega. 2020, 6(5): 3791-3799.

12) Lu Bai, Xiaojie Wang, Kaifu Zhang, Xiaoyue Tan, Yuying Zhang*, Wei Xie. Etchable SERS nanosensor for accurate pH and hydrogen peroxide sensing in living cells. Chemical Communications. 2019, 55: 12996-9.

13) Yuying Zhang*, Xue Mi, Xiaoyue Tan, Rong Xiang. Recent progress on liquid biopsy analysis using surface-enhanced Raman spectroscopy. Theranostics. 2019, 9: 491-525.

14) Yuying Zhang*, Xin-ping Wang, Sven Perner, Agnes Bankfalvi, Sebastian Schlücker*, Effect of antigen retrieval methods on non-specific binding of anti-body-metal nanoparticle conjugates on FFPE tissue, Analytical Chemistry, 2018, 90(10): 760-8.

论著：

1) Yuying Zhang, Chapter 8- iSERS Microscopy for Cellular and Tissue Imaging Ex Vivo. World Scientific, 05/2022; pp. 273-321, ISBN：978-981-123-525-2.

2) Yuying Zhang, Vi Tran, Mujo Adanalic, Sebastian Schlücker Chapter 9- iSERS microscopy: point-of-care diagnosis and tissue imaging. Elsevier, 10/2021; pp. 327-372, ISBN：978-0-12-821121-2.

 六、联系方式

1. 通讯地址：天津南开区卫津路94号南开大学医学院

2. E-mail：yuyingzhang@nankai.edu.cn