姓名：季学猛
职称：实验师

一、教育经历
  2011.9-2015.6 江南大学生物工程专业，工科学士
  2015.9-2018.3 浙江大学病原生物学专业，医学硕士
二、工作经历
  2018.7-2020.12 南开大学，医学院，助理实验师

2020.12 至今 南开大学，医学院，实验师

三、研究方向

食源性致病菌的环境耐受机制

四、代表性论文

长期从事食品安全研究，主要聚焦食源性致病菌的环境适应、耐受存活与毒力调控机制，围绕阪崎克罗诺杆菌等重要食品相关病原菌，系统开展干燥耐受、包膜稳态、脂质代谢调控及风险防控相关研究。申请人在食品安全领域积累了较为扎实的研究基础，累计发表SCI论文59篇，以第一/通讯作者发表SCI论文17篇，其中中科院一区top论文9篇，H-Index 19，i10-index 35，累计被引用1022次，申请国家发明专利8件，已授权3件。

1) P. Lu, J. Xue, A. Shi, and X. Ji, Opposing regulation of Gig2 by RecA and GlrK controls redox-linked desiccation tolerance in Cronobacter sakazakii. Food Microbiol, 2025. 132: 104860. 10.1016/j.fm.2025.104860.

2) P. Lu, J. Xue, A. Shi, and X. Ji, Hydrophilic guardians: Putative core proteins unaltered by 22 gene deletions mediate desiccation resistance in Cronobacter sakazakii. Food Microbiol, 2025. 131: 104814. 10.1016/j.fm.2025.104814.

3) P. Lu, J. Xue, A. Shi, and X. Ji, Sep, a YieP homolog, orchestrates membrane remodeling and multi-stress resistance in Salmonella enterica isolates from food. Int J Food Microbiol, 2025. 442: 111385. 10.1016/j.ijfoodmicro.2025.111385.

4) P. Lu, J. Xue, A. Shi, and X. Ji, Fatty acid metabolism governed by FadR is essential for Cronobacter sakazakii survival in dry food matrices and neonatal infection. Food Res Int, 2025. 221(Pt 1): 117229. 10.1016/j.foodres.2025.117229.

5) P. Lu, J. Xue, A. Shi, and X. Ji, The GlrKR two-component system modulates virulence, environmental stress responses, and p-coumaric acid sensitivity in Cronobacter sakazakii. Food Bioscience, 2025. 107622.

6) P. Lu, J. Xue, and X. Ji, RecA deletion disrupts protein homeostasis, leading to deamidation, oxidation, and impaired glycolysis in Cronobacter sakazakii. Appl Environ Microbiol, 2025. 91(1): e0197124. 10.1128/aem.01971-24.

7) J. Xue, J. Lv, L. Liu, F. Duan, A. Shi, X. Ji, and L. Ding, Maltodextrin-binding protein as a key factor in Cronobacter sakazakii survival under desiccation stress. Food Res Int, 2024. 177: 113871. 10.1016/j.foodres.2023.113871.

8) X. Ji, A. Shi, J. Wang, B. Zhang, Y. Hu, H. Lv, J. Wu, Y. Sun, J. M. Liu, Y. Zhang, and S. Wang, EnvZ/OmpR Controls Protein Expression and Modifications in Cronobacter sakazakii for Virulence and Environmental Resilience. J Agric Food Chem, 2024. 72(33): 18697-18707. 10.1021/acs.jafc.4c04627.

9) X. Ji, D. Fan, J. Wang, B. Zhang, Y. Hu, H. Lv, J. Wu, Y. Sun, J. Liu, Y. Zhang, and S. Wang, Cronobacter sakazakii lysozyme inhibitor LprI mediated by HmsP and c-di-GMP is essential for biofilm formation and virulence. Appl Environ Microbiol, 2024. 90(10): e0156424. 10.1128/aem.01564-24.