姓名：庄洁
职称：副教授

一、研究方向

（1）线粒体蛋白转运机制及其在代谢相关疾病中的作用研究

（2）纳米酶设计及其生物医学应用研究
二、教育背景

2005-2010博士，中国科学院生物物理研究所

2000-2004学士，北京理工大学

三、工作经历
2019-至今南开大学医学院，副教授，

2012-2019研究助理，美国国立卫生研究院 (National Institutes of Health)

2011-2012博士后，美国国立卫生研究院 (National Institutes of Health)

四、部分发表论文

1)Huang, X*, Zhuang, J*, Chung, SW, Halpert, G, Negron, K, Huang, B, Hwang, PM, Hanes, J, Suk, JS. Hypoxia-tropic Protein Nanocages for Modulation of Tumor- and Chemotherapy-associated Hypoxia. ACS Nano. 2019, 13: 236–247 (*Co-first author)

2) Wang, P, Li, J, Walcott, F, Kang, J, Starost, M, Talagala, SL, Zhuang J, Park, J, Huffstutler, R, Bryla, C, Mai, P, Pollak, M, Annunziat, C, Savage, S, Fojo, A, Hwang, PM. Inhibiting mitochondrial respiration prevents cancer in a mouse model of Li-Fraumeni syndrome.Journal of Clinical Investigation. 2017, 127: 132-136.

3) Zhuang, J, Kamp W, Li, J, Liu, C, Kang, J, Wang, P, Hwang, PM. FOXO3 and CHCHD4 regulate p53 nuclear activity in response to exercise.The Journal of Biological Chemistry. 2016, 291: 24819-24827.

4)Zhuang, J, Wang, P, Huang, X, Chen, X, Kang, J, Hwang, PM.Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity. Proc Natl Acad Sci U S A. 2013, 110: 17356-17361. (Recommended by Faculty of 1000)

5)Wang, P, Ma, W, Park, J, Celi, FS, Arena, R, Choi, JW, Ali, QA, Tripodi, DJ, Zhuang, J, Lago, CU, Strong, LC, Talagala, SL, Balaban, RS, Kang, J, Hwang, PM. Increased Oxidative Metabolism in the Li–Fraumeni Syndrome. New England Journal of Medicine. 2013, 368: 1027-1032.

6)Zhuang, J, Ma, W, Lago, CU, Hwang, PM. Metabolic regulation of oxygen and redox homeostasis by p53: Lessons from evolutionary biology? Free Radical Biology and Medicine. 2012, 53: 1279-1285.

7)Zhuang, J, Fan, K, Gao, L, Lu, D, Feng, J, Yang, D, Gu, N, Zhang, Y, Liang, M, Yan, X. Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using Their Intrinsic Peroxidase-Mimicking Activity. Molecular Pharmaceutics. 2012, 9: 1983-1989.

8)Jiang, T, Zhuang, J, Duan, H, Luo, Y, Zeng, Q, Fan, K, Yan, H, Lu, D, Ye, Z, Hao, J, Feng, J, Yang, D, Yan, X. CD146 is a co-receptor for VEGFR-2 in tumor angiogenesis. Blood. 2012, 120: 2330-2339.

9)Zhuang, J, Jiang, T, Lu, D, Luo, Y, Zheng, C, Feng, J, Yang, D, Chen, C, Yan, X. NADPH oxidase 4 mediates reactive oxygen species induction of CD146 dimerization in VEGF signal transduction. Free Radical Biology and Medicine. 2010, 49: 227-236.

10)Zhuang, J, Zhang, J, Gao, L, Zhang, Y, Gu, N, Feng, J, Yang, D, Yan, X. A novel application of iron oxide nanoparticles for detection of hydrogen peroxide in acid rain. Materials Letters. 2008, 62: 3972-3974.

11)Wang, L, Li, P, Zhuang J, Bai, F, Feng, J, Yan, X, Li, Y. Carboxylic acid enriched nanospheres of semiconductor nanorods for cell imaging. Angew Chem Int Ed Engl. 2008, 47: 1054-1057.

12)Gao, L*, Zhuang, J*, Nie, L, Zhang, J, Zhang Y, Gu, N, Wang, T, Feng, J, Yang, D, Perrett, S, Yan, X. Intrinsic peroxidase-like activity of ferromagnetic nanoparticles. Nature Nanotechnology. 2007, 2: 577-583. (*Co-first author, highly cited paper)

五、荣誉和奖励

2014美国国立卫生研究院心肺血研究所，NHLBI Director’s Award

2014美国国立卫生研究院心肺血研究所，Orloff Science Award

2014北京市科学技术奖一等奖

2010北京市科学技术奖一等奖

六、联系方式
通讯地址：天津市南开区卫津路94号南开大学药物化学生物学国家重点实验室304
E-mail：zhuangj@nankai.edu.cn