姓名：王德坤

职称：副教授

一、教育经历

2016.09-2019.06，南开大学，生物化学与分子生物学专业，博士

2008.09-2011.06，南开大学，遗传学专业，硕士

2004.09-2008.06，山东大学，生物技术专业，学士

二、工作经历

2019.07至今，南开大学医学院，讲师

2014.01-2016.08，南开大学医学院，实验师

2011.09-2013.12，南开大学医学院，助理实验师

三、研究方向（包括承担课题项目）

1. 肾间质纤维化的分子调控机制研究

2. 溶酶体稳态在肾脏生理功能维持中的作用及机制研究

作为项目负责人的科研项目：

1. 南开大学2020年度基本科研业务费项目，Legumain通过维持溶酶体稳态抑制肾小管上皮细胞衰老及肾间质纤维化的研究

作为课题骨干参与的科研项目：

1. 国家自然科学基金委面上项目，肿瘤相关巨噬细胞来源legumain通过调控细胞衰老作用于肿瘤进展的机制研究，2019-01 至 2022-12

2. 国家自然科学基金委面上项目，M2巨噬细胞表达Legumain促进肾间质纤维化损伤修复的机理及应用研究，2013-01 至 2016-12

四、已发表的论文

期刊论文

（1）Dekun Wang, Min Xiong, Chuan’ai Chen, Lingfang Du, Ze Liu, Yuzhi Shi, Mianzhi Zhang, Junbo Gong, Xiangrong Song, Rong Xiang, Ergang Liu, and Xiaoyue Tan*, Legumain, an asparaginyl endopeptidase, mediates the effect of M2 macrophages on attenuating renal interstitial fibrosis in obstructive nephropathy. Kidney International, 2018, 94(1): 91-101.

（2）Dekun Wang#, Qingwen Meng#, Lihong Huo, Meng Yang, Lingling Wang, Xinyu Chen, Jianchao Wang, Zhiguo Li, Xiaoying Ye, Na Liu, Qiuyan Li, Zhen Dai, Hongsheng Ouyang, Ning Li, Jun Zhou*, Lingyi Chen*, and Lin Liu*, Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein & Cell, 2015. 6(2): p. 152-6.

（3）Long Shen#., Lichun Kang#, Dekun Wang, Jing Xun, Chuan’ai Chen, Lingfang Du, Mianzhi Zhang, Junbo Gong, Xue Mi, Shijing Yue, Yuying Zhang, Xiangrong Song, Rong Xiang, Zhujun Zhang*, and Xiaoyue Tan*, Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation. Cancer Letters, 2020. 472: p. 40-49.

（4）Lingyi Chen*, Dekun Wang, Zhaoting Wu, Liping Ma, and Geroge Q Daley*, Molecular basis of the first cell fate determination in mouse embryogenesis. Cell Research, 2010. 20(9): p. 982-93.

（5）Jing Xun, Dekun Wang, Long Shen, Junbo Gong, Ruifang Gao, Lingfang Du, Antao Chang, Xiangrong Song, Rong Xiang, and Xiaoyue Tan*, JMJD3 suppresses stem cell-like characteristics in breast cancer cells by downregulation of Oct4 independently of its demethylase activity. Oncotarget, 2017. 8(13): p. 21918-21929.

（6）Long Shen, Kunhua Qin, Dekun Wang, Yan Zhang, Nan Bai, Shengyong Yang, Yunping Luo, Rong Xiang, and Xiaoyue Tan*, Overexpression of Oct4 suppresses the metastatic potential of breast cancer cells via Rnd1 downregulation. Biochim Biophys Acta-molecular basis of disease, 2014. 1842(11): p. 2087-95.

（7）Hongjie Liu#, Zhaoting Wu#, Xianle Shi#, Wenzhi Li#, Chang Liu, Dekun Wang, Xiaoying Ye, Lin Liu, Jie Na*, Hong Cheng*, and Lingyi Chen*, Atypical PKC, regulated by Rho GTPases and Mek/Erk, phosphorylates Ezrin during eight-cell embryo compaction. Developmental Biology, 2013. 375(1): p. 13-22.

（8）Lichun Kang, Long Shen, Liqing Lu, Dekun Wang, Yong Zhao, Chuan’ai Chen, Lingfang Du, Junbo Gong, Yuying Zhang, Xue Mi, Rong Xiang, Mianzhi Zhang*, and Xiaoyue Tan,* Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1. Biochim Biophys Acta-molecular basis of disease, 2019. 1865(9): p. 2267-2275.

（9）Long Shen, Honghao Li, Yuzhi Shi, Dekun Wang, Junbo Gong, Jing Xun, Sifan Zhou, Rong Xiang, and Xiaoyue Tan*, M2 tumour-associated macrophages contribute to tumour progression via legumain remodelling the extracellular matrix in diffuse large B cell lymphoma. Scientific Reports, 2016. 6: p. 30347.

会议论文

（1）Dekun Wang, Zhujun Zhang, and Xiaoyue Tan, Proteomic identification of exosomal VDAC1: a potential urinary biomarker for detecting early renal fibrosis, International society for extracellular vesicles 2017 Annual Meeting, Westin Harbour Castle in Toronto, Ontario, Canada. 2017.05.18-21

（2）Dekun Wang, Chuan’ai Chen, Lichun Kang, and Xiaoyue Tan, Loss of Asparaginyl endopeptidase accelerates cellular senescence and boosts age-related renal interstitial fibrosis, ASN Kidney Week 2018, at San Diego Convention Center in San Diego, CA. USA. 2018.10.23-28

（3）Chuan’ai Chen, Dekun Wang, Yangyang Yu, Yong Zhao, and Xiaoyue Tan, Asparaginyl endopeptidase deficiency protects against AKI via inhibition of tubular ferroptosis. ASN Kidney Week 2019, at Walter E. Washington Convention Center in Washington, DC. USA. 2019.11.05-10

五、讲授课程

1. 病理学

六、联系方式

1. 通讯地址：天津市南开区卫津路94号
 2. 电话：02223509482
 3. mail：wangdekun@nankai.edu.cn