姓名：纳静

职称：讲师

一、教育背景

2016.9-2024.6，北京航空航天大学，生物与医学工程学院，生物医学工程专业，博士

2012.9-2016.7，北京林业大学，生物科学与技术学院，生物科学专业，学士

二、工作经历

2024.07-至今，南开大学，医学院，讲师

三、研究方向

1. 骨科生物力学与力学生物学

2. 生物材料与骨组织修复及再生研究

3. 物理因子调控干细胞分化及机制研究

四、科研项目

1. 国家自然科学基金青年项目，基质硬化通过α-酮戊二酸介导组蛋白去甲基化调控退行性骨关节炎进展的机制研究，2026.01-2028.12，主持

2. 天津市自然科学基金青年项目，基质硬化通过柠檬酸代谢介导的染色质重塑调控软骨细胞衰老的机制研究，2024.10-2026.09，主持

3. 南开大学视光科学研究院一般项目，圆锥角膜生物力学理论与实验研究，2024.04-2026.03，参与

4. 天津市卫生健康科技项目青年项目，搭载多效融合外泌体的导电水凝胶促进脊髓损伤神经再生的应用研究，2025.07-2027.06，参与

五、学术兼职

1. 中国生物医学工程学会 会员

2. 中国生物材料学会 会员

六、近五年发表论文

1. Na J^†, Tai C^†, Yang Z, Chen X, Wang Z, Liu Y, Zhang J, Zheng L*, Fan Y*. Stiff extracellular matrix drives the differentiation of mesenchymal stem cells toward osteogenesis by the multiscale 3D genome reorganization. Biomaterials. 2025, 312: 122715.

2. Na J, Yang Z, Shi Q, Shi Q, Li C, Liu Y, Song Y, Li X, Zheng L*, Fan Y*. Extracellular matrix stiffness as an energy metabolism regulator drives osteogenic differentiation in mesenchymal stem cells. Bioactive Materials. 2024, 35: 549-563.

3. Na J, Shi Q, Yang Z, Liu Y, Chen X, Wang Z, Zheng L*, Fan Y*. Mechanical memory based on chromatin and metabolism remodeling promotes proliferation and smooth muscle differentiation in mesenchymal stem cells. FASEB Journal. 2024, 38(6): e23538.

4. Na J^†, Zheng L^†*, Wang L, Shi Q, Yang Z, Liu N, Guo Y, Fan Y*. Phenytoin regulates migration and osteogenic differentiation by MAPK pathway in human periodontal ligament cells. Cellular and Molecular Bioengineering, 2022, 15(1): 151-160.

5. Na J^†, Zhang L^†, Zheng L*, Jiang J, Shi Q, Li C, Fan Y*. Static magnetic field regulates proliferation, migration, and differentiation of human dental pulp stem cells by MAPK pathway. Cytotechnology. 2022, 74(3): 395-405.

6. Liu Y, Yang Z, Na J, Chen X, Wang Z, Zheng L*, Fan Y*. In vitro stretch modulates mitochondrial dynamics and energy metabolism to induce smooth muscle differentiation in mesenchymal stem cells. FASEB J. 2025, 39(2):e70354.

7. Shi Q, Zheng L*, Na J, Li X, Yang Z, Chen X, Song Y, Li C, Zhou L, Fan Y*. Fluid shear stress promotes periodontal ligament cells proliferation via p38-AMOT-YAP. Cellular and Molecular Life Sciences. 2022, 79(11): 551.

8. Liu Y, Liu N, Na J, Li C, Yue G, Fan Y*, Zheng L*. Wnt/β-catenin plays a dual function in calcium hydroxide induced proliferation, migration, osteogenic differentiation, and mineralization in vitro human dental pulp stem cells. International Endodontic Journal. 2022, 56(1): 92-102.

9. Shi Q, Song Y, Cao J, Na J, Yang Z, Chen X, Wang Z, Fan Y*, Zheng *L. Inhibition of Mitochondrial Fission Reverses Simulated Microgravity-Induced Osteoblast Dysfunction by Enhancing Mechanotransduction and Epigenetic Modification. Research. 2025, 4;8:0602.

10. Zhang K, Zhu X, Chen W, Na J, Miao N, Gao Y, Wang Z, Zhu Y, Yang S, Zhang Y. Equilibrium Mechanics in Fracture Reduction of Tibial Plateau. Orthopaedic Surgery. 2025. doi: 10.1111/os.70133.

11. Shi Q, Gui J, Sun L, Song Y, Na J, Zhang J, Fan Y*, Zheng L*. Frizzled-9 triggers actin polymerization and activates mechano-transducer YAP to rescue simulated microgravity-induced osteoblast dysfunction. FASEB Journal. 2023, 37(9): e23147.

12. Qian Z, Bai Y, Zhou J, Li L, Na J, Fan Y*, Guo X*, Liu H*. A moisturizing chitosan-silk fibroin dressing with silver nanoparticles-adsorbed exosomes for repairing infected wounds. Journal of Materials Chemistry B. 2020, 8(32): 7197-7212.

13. Li C, Meng F, Yang Z, Peng, J, Guo Y, Na J, Shi Q, Liu Y, Wang Y*, Zheng L*, Fan Y*. Micropattern‐based stem cell gym: mechanical memory enhanced stemness maintenance of human dental pulp stem cells and nerve regeneration. Advanced Functional Materials. 2023, 33(49): 2302829.

14. Shi Q, Song F, Zhou X, Chen X, Cao J, Na J, Fan Y*, Zhang G*, Zheng L*. Early predicting osteogenic differentiation of mesenchymal stem cells based on deep learning within one day. Annals of Biomedical Engineering. 2024, 52(6):1706-1718.

七、讲授课程

1. 系统生物学

2. 智能医学临床应用实践

3. 创新研究与训练

八、联系方式

1. 通信地址：天津市南开区卫津路94号

2. 电子邮箱：9920240103@nankai.edu.cn