姓名：张诗武

职称：主任医师，教授

一、教育经历

1. 1992.09-1997.07，天津医科大学，临床医学，本科

2. 2000.09-2003.07，天津医科大学，病理学和病理生理学，硕士

3. 2005.09-2008.07，天津医科大学，肿瘤学，博士

4. 2010.04-2011.03，美国M.D.Anderson癌症中心，访问副教授

5. 2011.04-2013.01，美国M.D.Anderson癌症中心，博士后

二、工作经历

1. 1997.07-2002.12，天津武警医学院，病理教研室，助教

2. 2003.01-2005.03，天津武警医学院，病理教研室，讲师

3. 2005.04-2007.12，天津医科大学附属肿瘤医院，病理科，讲师

4. 2007.12-2013.03，天津医科大学附属肿瘤医院，病理科，副教授

5. 2013.03-至今，天津人民医院，病理科，主任医师

三、研究方向（包括承担课题项目）

研究方向：

1.肿瘤干细胞与肿瘤血管生成、肿瘤增殖、转移复发及耐药的机制

2.三阴乳腺癌的发病机制

承担课题项目：

1. 缺氧调节S100A10 SUMO化修饰及亚细胞定位促进PGCCs产生的子代细胞侵袭转移相关机制，82173283，202201-202512，国家自然科学基金面上项目，54.7万元，项目负责人；

2.c-Myc-Gcn5-HDAC2在调节PGCCs产生红细胞及其成熟过程中的机制，81672426，201701-202012，国家自然科学基金面上项目，57万元，项目负责人；

3.缺氧诱导具有干细胞特性的多倍体巨细胞形成及不对称分裂机制，81472729，201501-201812，国家自然科学基金面上项目，72万元，项目负责人；

4.外源性雌孕激素诱导TA2雌鼠乳腺癌发生相关分子机制， 81071631，201101-201312，国家自然科学基金面上项目，57万元，项目负责人；

5.活体微循环的微米级分辨动态分子影像技术与恶性实体瘤早期诊断，91859123，201901-202112，国家自然科学基金重大研究计划，30万元，项目第一参与人；

6. SUMO化修饰促进S100A10入核调节PGCCs产生的子代细胞侵袭转移相关机制，21JCZDJC00230，202110-202409，天津市自然科学基金重点项目，40万元，项目负责人；

7.结直肠癌患者术后转移预测的早期诊断和防治策略，17ZXMFSY00120，201710-202009，天津市科技重大专项，200万元，项目负责人。

8. 缺氧诱导肿瘤细胞PGCCs形成及产生红细胞相关分子机制，13JCYBJC42700，201310-201609，天津市应用基础与前沿技术研究计划，10万元，项目负责人。

四、学术兼职

1. 天津市整合医学会病理专业委员会主任委员

2. 天津市医师协会病理科医师分会第二届委员会副会长

3. 天津市病理质控中心副主任委员

4. 天津抗癌协会肿瘤临床检验专业委员会第一届委员会副主任委员

5. 天津市整合医学学会胃肠道肿瘤急腹症专委员会副主任委员

6. 天津市整合医学学会血液病综合诊疗专业委员会常务委员

7. 天津市抗癌协会第六届理事会常务理事

8. 天津市抗癌协会胃癌专业委员会委员

9. 天津市干细胞临床研究专家委员委员

10. 天津医药杂志编委

11. Frontiers in Oncology杂志主编

12. World Journal of Clinical Cases杂志编辑

五、近五年发表的学术论文

近五年以第一作者和通讯作者所发表的代表性论文（影响因子＞4.0）：

1. Fan L, Zheng M, Zhou X, Yu Y, Ning Y, Fu W, Xu J, Zhang S. Molecular mechanism of vimentin nuclear localization associated with the migration and invasion of daughter cells derived from polyploid giant cancer cells. J Transl Med. 2023 Oct 13;21(1):719. (IF=7.4001) 

2. Huang P, Zhou X, Zheng M, Yu Y, Jin G, Zhang S. Regulatory T cells are associated with the tumor immune microenvironment and immunotherapy response in triple-negative breast cancer. Front Immunol. 2023 Sep 12;14:1263537. (IF=7.3)

3. Wang J, Zheng M, Yang X, Zhou X, Zhang S. The Role of Cathepsin B in Pathophysiologies of Non-tumor and Tumor tissues: A Systematic Review. 2023;14:(12) 2344-2358(IF=4.478)

4. Zhang A, Zhang S. Clinicopathological significance of vasculogenic mimicry and fetal hemoglobin expression in peripheral neuroblastic tumors in children. Am J Transl Res. 2023 Jul 15;15(7):4687-4698. (IF=3.9)

5. Yang X, Zheng M, Ning Y, Sun J, Yu Y, Zhang S. Prognostic risk factors of serous ovarian carcinoma based on mesenchymal stem cell phenotype and guidance for therapeutic efficacy. J Transl Med. 2023 Jul 11;21(1):456. (IF=8.44)

6. Zheng M, Chen L, Fu J, Yang X, Chen S, Fu W, Li Y, Zhang S. Cdc42 Regulates the Expression of Cytoskeleton and Microtubule Network Proteins to Promote Invasion and Metastasis of Progeny Cells Derived from CoCl2-induced Polyploid Giant Cancer Cells. J Cancer. 2023 Jun 26;14(10):1920-1934. (IF=4.478)

7. Chen L, Zhang X, Liu G, Chen S, Zheng M, Zhu S, Zhang S. Fibroblast growth factor 3 promotes spontaneous mammary tumorigenesis in Tientsin albino 2 mice via the FGF3/FGFR1/STAT3 pathway. Front Oncol. 2023 Jul 11;13:1161410. (IF=5.738)

8. Zhou M, Zheng M, Zhou X, Tian S, Yang X, Ning Y, Li Y, Zhang S. The roles of connexins and gap junctions in the progression of cancer. Cell Commun Signal. 2023 Jan 13;21(1):8. (IF=7.525)

9. Fu F, Niu R, Zheng M, Yang X, Fan L, Fu W, Zhang S. Clinicopathological Significances and Prognostic Value of PPFIA4 in Colorectal Cancer. J Cancer. 2023 Jan 1;14(1):24-34. (IF=4.478)

10. Zhang K, Yang X, Zheng M, Ning Y, Zhang S. Acetylated-PPARγ expression is regulated by different P53 genotypes associated with the adipogenic differentiation of polyploid giant cancer cells with daughter cells. Cancer Biol Med. 2023 Jan 12;20(1):56–76. (IF=5.347)

11. Tian S, Xu X, Yang X, Fan L, Jiao Y, Zheng M, Zhang S. Roles of follistatin-like protein 3 in human non-tumor pathophysiologies and cancers. Front Cell Dev Biol. 2022 Oct 17;10:953551. (IF=5.738)

12. Zhou X, Zhou M, Zheng M, Tian S, Yang X, Ning Y, Li Y, Zhang S. Polyploid giant cancer cells and cancer progression. Front Cell Dev Biol. 2022 Oct 5;10:1017588. (IF=6.081)

13. Yan M, Zheng M, Niu R, Yang X, Tian S, Fan L, Li Y, Zhang S. Roles of tumor-associated neutrophils in tumor metastasis and its clinical applications. Front Cell Dev Biol. 2022 Aug 17;10:938289. (IF=6.081)

14. Fu F, Chen L, Yang X, Fan L, Zhang M, Chen S, Zheng M, Gao M, Zhang S. PLK4 is a key molecule in the formation of PGCCs and promotes invasion and migration of progeny cells derived from PGCCs. J Cancer. 2022 Jul 18;13(9):2954-2969. (IF=4.478)

15. Fan L, Yang X, Zheng M, Yang X, Ning Y, Gao M, Zhang S. Regulation of SUMOylation Targets Associated With Wnt/β-Catenin Pathway. Front Oncol. 2022 Jun 30;12:943683. (IF=5.738)

16. Yang X, Tian S, Fan L, Niu R, Yan M, Chen S, Zheng M, Zhang S. Integrated regulation of chondrogenic differentiation in mesenchymal stem cells and differentiation of cancer cells. Cancer Cell Int. 2022 Apr 29;22(1):169. (IF=6.429)

17. Zhang H, Ma H, Yang X, Fan L, Tian S, Niu R, Yan M, Zheng M, Zhang S. Cell Fusion-Related Proteins and Signaling Pathways, and Their Roles in the Development and Progression of Cancer. Front Cell Dev Biol. 2022 Feb 1;9:809668. (IF=6.081)

18. Chen L, Zhang X, Liu G, Chen S, Zheng M, Zhu S, Zhang S. Intestinal Immune System and Amplification of Mouse Mammary Tumor Virus. Front Cell Infect Microbiol. 2022 Jan 13;11:807462. (IF=6.429)

19. Fu J, Liu B, Zhang H, Fu F, Yang X, Fan L, Zheng M, Zhang S. The role of cell division control protein 42 in tumor and non-tumor diseases: A systematic review. J Cancer. 2022 Jan 1;13(3):800-814. (IF=4.427)

20. Li Z, Zheng M, Zhang H, Yang X, Fan L, Fu F, Fu J, Niu R, Yan M, Zhang S. Arsenic Trioxide Promotes Tumor Progression by Inducing the Formation of PGCCs and Embryonic Hemoglobin in Colon Cancer Cells. Front Oncol. 2021 Oct 5;11:720814. (IF=6.429)

21. Zhao Q, Zhang K, Li Z, Zhang H, Fu F, Fu J, Zheng M, Zhang S. High Migration and Invasion Ability of PGCCs and Their Daughter Cells Associated With the Nuclear Localization of S100A10 Modified by SUMOylation. Front Cell Dev Biol. 2021 Jul 16;9:696871. (IF=6.684)

22. Sun J, Xu J, Sun C, Zheng M, Li Y, Zhu S, Zhang S. Screening and Prognostic Value of Methylated Septin9 and its Association With Clinicopathological and Molecular Characteristics in Colorectal Cancer. Front Mol Biosci. 2021 May 20;8:568818. (IF=5.246)

23. Zhang K, Zhao Q, Li Z, Fu F, Zhang H, Fu J, Zheng M, Zhang S. Clinicopathological Significances of Cancer Stem Cell-Associated HHEX Expression in Breast Cancer. Front Cell Dev Biol. 2020 Dec 23;8:605744. (IF=6.684)

24. Zhao Q, Ma Y, Li Z, Zhang K, Zheng M, Zhang S. The Function of SUMOylation and Its Role in the Development of Cancer Cells under Stress Conditions: A Systematic Review. Stem Cells Int. 2020 Nov 13;2020:8835714. (IF=5.443)

25. Fu F, Yang X, Zheng M, Zhao Q, Zhang K, Li Z, Zhang H, Zhang S. Role of Transmembrane 4 L Six Family 1 in the Development and Progression of Cancer. Front Mol Biosci. 2020 Aug 18;7:202. (IF=5.246)

26. Zhang K, Yang X, Zhao Q, Li Z, Fu F, Zhang H, Zheng M, Zhang S. Molecular Mechanism of Stem Cell Differentiation into Adipocytes and Adipocyte Differentiation of Malignant Tumor. Stem Cells Int. 2020 Aug 12;2020:8892300. (IF=5.443)

27. Liu K, Zheng M, Lu R, Du J, Zhao Q, Li Z, Li Y, Zhang S. The role of CDC25C in cell cycle regulation and clinical cancer therapy: a systematic review. Cancer Cell Int. 2020 Jun 3;20:213. (IF=5.722)

28. Du J, Zhao Q, Liu K, Li Z, Fu F, Zhang K, Zhang H, Zheng M, Zhao Y, Zhang S. FGFR2/STAT3 Signaling Pathway Involves in the Development of MMTV-Related Spontaneous Breast Cancer in TA2 Mice. Front Oncol. 2020 May 5;10:652. (IF=6.244)

29. Fei F, Liu K, Li C, Du J, Wei Z, Li B, Li Y, Zhang Y, Zhang S. Molecular Mechanisms by Which S100A4 Regulates the Migration and Invasion of PGCCs With Their Daughter Cells in Human Colorectal Cancer. Front Oncol. 2020 Feb 21;10:182. (IF=6.244)

30. Liu K, Zheng M, Zhao Q, Zhang K, Li Z, Fu F, Zhang H, Du J, Li Y, Zhang S. Different p53 genotypes regulating different phosphorylation sites and subcellular location of CDC25C associated with the formation of polyploid giant cancer cells. J Exp Clin Cancer Res. 2020 May 11;39(1):83. (IF=11.161)

31. Li C, Ma Y, Fei F, Zheng M, Li Z, Zhao Q, Du J, Liu K, Lu R, Zhang S. Critical role and its underlying molecular events of the plasminogen receptor, S100A10 in malignant tumor and non-tumor diseases. J Cancer. 2020 Jan 1;11(4):826-836. (IF=4.427)

32. Fei F, Li C, Cao Y, Liu K, Du J, Gu Y, Wang X, Li Y, Zhang S. CK7 expression associates with the location, differentiation, lymph node metastasis, and the Dukes' stage of primary colorectal cancers. J Cancer. 2019 Jun 2;10(11):2510-2519. (IF=4.427)

33. Fei F, Li C, Wang X, Du J, Liu K, Li B, Yao P, Li Y, Zhang S. Syncytin 1, CD9, and CD47 regulating cell fusion to form PGCCs associated with cAMP/PKA and JNK signaling pathway. Cancer Med. 2019 Jun;8(6):3047-3058. (IF=4.000)

34. Fei F, Qu J, Liu K, Li C, Wang X, Li Y, Zhang S. The subcellular location of cyclin B1 and CDC25 associated with the formation of polyploid giant cancer cells and their clinicopathological significance. Lab Invest. 2019 Apr;99(4):483-498. (IF=5.662)

35. Zhang S, Fei F, Wang H, Gu Y, Li C, Wang X, Zhao Y, Li Y. Stromal immunoglobulin κC expression is associated with initiation of breast cancer in TA2 mice and human breast cancer. Cancer Sci. 2018 Jun;109(6):1825-1833. (IF=6.716)

36. Wang X, Fei F, Qu J, Li C, Li Y, Zhang S. The role of septin 7 in physiology and pathological disease: A systematic review of current status. J Cell Mol Med. 2018 Jul;22(7):3298-3307. (IF=5.299)

六、荣誉和奖励

荣誉：

1. 2022年获得天津市优秀科技工作者荣誉称号

2. 2021年获得天津市卫生健康委系统“最美科技工作者”荣誉称号

3. 2021年获得天津市人民医院优秀导师团队荣誉称号

4. 2020年获得天津市红桥区拔尖人才荣誉称号

5. 2016年获得天津市“131创新型人才团队-结直肠癌创新团队”带头人

6. 2014年获得天津市“131创新型人才培养工程第一层次人选”

科技奖励：

1. 基于60000余例肛周疾病建立的规范化诊疗体系，2020-JB-2-076-R2，天津市科技进步二等奖，第二完成人；

2. 6000余例中低位直肠癌临床诊治及随访，2018JB-2-055，天津市科技进步二等奖，第三完成人；

3.多倍体肿瘤巨细胞在肿瘤发生发展过程中的作用及其机制，2016JB-3-084，天津市科技进步三等奖，第一完成人；

4.大肠癌发生与器官特异性转移机制及干预的研究，2006JB-1-007-R3，天津市科技进步一等奖，第三完成人；

5.双向分化恶性肿瘤血管生成拟态分子机制研究，2004ZR-3-011-R3，天津市自然科学三等奖，第三完成人；

6.国家发明专利：张诗武，刘筠，王弋嘉。干细胞小球诱导培养液及干细胞小球培养方法，第一申请人，专利号：ZL2013 1 0286095.3

7.国家发明专利：张诗武，张可昕，李玉玮。地塞米松，罗格列酮，3-异丁基-甲基黄嘌呤组合物在制备抑制受氯化钴诱导的卵巢癌细胞生长转移的药物中的用途，第一申请人，专利号：ZL 2020 1 0337378.6

七、联系方式

1.通讯地址：天津市红桥区芥园道190号天津市人民医院病理科

2.电话：15620876109

3. E-mail：zhangshiwu666@aliyun.com