喻文立(博士生导师)

名:喻文立

职称:主任医师

一、教育经历

1.19909-19956月,天津医科大学/医学系,大学本科

2.20019-20046月,天津医科大学/麻醉学,硕士学位

3.20059-20086月,天津医科大学/中西医结合临床,博士学位

二、工作经历

1.19958-20017月,天津市第一中心医院,麻醉科,医师

2.20018-200710月,天津市第一中心医院,麻醉科,主治医师

3.200711-201211月,天津市第一中心医院,麻醉科,副主任医师

4.201212-至今,天津市第一中心医院,麻醉科,主任医师

5.20153-20154月,美国约翰霍普金斯医院/麻醉学,访问学者

6.20182-20188月,美国加州大学洛杉矶分校/麻醉学,访问学者

7.20106-201912月,天津市第一中心医院,麻醉科,科副主任

8.201912-至今,天津市第一中心医院,麻醉科,科主任

三、研究方向

主要研究方向为器官移植围术期重要器官功能保护

承担课题

12021.01-2024.12,外泌体microRNA-122介导肝缺血再灌注致发育期海马损伤的机制研究,主持,国家自然科学基金面上项目,82072219

22020.08-2023.08,儿童肝移植肺损伤敏感性microRNA预测模型建立及调控机制研究,主持,天津市卫生健康委员会科技项目,ZC20177

32020.08-2023.08miRNA29a参与儿童肝移植心肌损伤机制研究,参加,天津市卫生健康委员会科技项目,ZC20052

42018.04-2021.03,肝缺血再灌注通过NMDAR/PSD95/nNOS途径导致生长发育期大脑损伤机制及异丙酚保护作用研究,主持2018天津市自然科学基金面上项目,18JCYBJC27500

52018.01-2020.12,基于AMPK/Sirt1通路介导的自噬探讨小檗碱对移植肾缺血再灌注损伤的保护作用及机制,参加,国家自然科学基金青年项目,81700659

62017.04-2020.03,小檗碱对脂肪供肝缺血再灌注损伤中自噬-凋亡平衡调控的机制研究,参加,2017天津市自然科学基金面上项目,17JCYBJC28000

72017.10-2019.09,黄连素上调自噬减轻移植肾缺血再灌注损伤的机制研究,主持,天津市卫生和计划生育委员会中医中西医结合科研课题,2017056

82016.10-2019.09,小儿肝移植相关脑损伤机制及异丙酚保护作用研究,主持,天津市卫生计生委科技攻关项目,16KG101

四、学术兼职

中华医学会麻醉学分会器官移植麻醉学组副组长,中国医师协会麻醉学医师分会委员、中国中西医结合学会围手术期专业委员会常委,中国医药教育协会麻醉分会常委、天津市医学会麻醉学分会副主任委员、天津市医师协会麻醉医师分会副会长、天津市临床麻醉质控中心副主任、天津市中西医结合学会麻醉与镇痛委员会副主任委员,中华麻醉学杂志通讯编委、国际麻醉与复苏杂志通讯编委、麻醉安全与质控杂志编委、实用器官移植电子杂志编委。

五、近五年发表的学术论文

  1. LiliJia , WenliYu*, Hongli Yu, and Yiqi Weng. Electroacupuncture PretreatmentAttenuates Intestinal InjuryafterAutogenous Orthotopic Liver Transplantation in Rats via theJAK/STATPathway. Oxid Med Cell Longev. 2020 Aug 4;2020:9187406. (通讯作者,IF=5.076)

  2. Zhang L,Liu H, Jia L, Lyu J, Sun Y, Yu H, Li H, Liu W, Weng Y, YuW*.ExosomesMediate Hippocampal and Cortical Neuronal Injury Induced by HepaticIschemia-Reperfusion Injury through Activating Pyroptosis in Rats.Oxid Med Cell Longev. 2019 Nov 13;2019:3753485. (通讯作者,IF=5.076)

  3. LiHongxia, Weng Yiqi, Yuan Shaoting, Liu Weihua, Yu Hongli, YuWenli*.Effect of sevoflurane and propofol on acute kidney injury inpediatric living donor liver transplantation. Ann Transl Med, 2019,7(14), 340.  (通讯作者,IF=3.689)

  4. Qiang Zhe,YuWenli*.Chemokine CCL7 regulates spinal phosphorylation of GluA1-containingAMPA receptor via interleukin-18 in remifentanil-inducedhyperalgesia in rats. Neurosci Lett, 2019,711, 134440. (通讯作者,IF= 2.173)

  5. Sun Ying,Jia Lili, Yu Hongli, Zhu Min, Sheng Mingwei, YuWenli*.The Effect of Pediatric Living Donor Liver Transplantation onNeurocognitive Outcomes in Children. Ann Transplant, 2019, 24,446-453.  (通讯作者,IF= 1.369)

  6. YuXiangyang, Jia Lili, YuWenli*,Du Hongyin. Dephosphorylation by calcineurin regulates translocationof dynamin- T related protein 1 to mitochondria in hepatic ischemiareperfusion induced hippocampus injury in young mice, Brain Res,2019, 1711: 68-76. (通讯作者,IF=3.125)

  7. XuWeituan, Liu Weihua, YuWenli*.The involvement of iron responsive element (-) divalent metaltransporter 1-mediated the spinal iron overload via CXCL10/CXCR3pathway in neuropathic pain in rats. Neurosci Lett, 2019,16;694:154-160. (通讯作者,IF=2.173)

  8. XiangyangYu, Lili Jia, Kuoqi Yin, Jingshu Lv, WenliYu*,Hongyin Du. Src is Implicated in Hepatic IschemiaReperfusion-Induced Hippocampus Injury and Long-Term CognitiveImpairment in Young Mice via NMDA Receptor Subunit2A Activation.Neuroscience. 2018, 1;391:1-12.(通讯作者,IF=3.362)

  9. Wang Gang,Li Jinyuan, Weng Yiqi, Ding Mei, Yu Hongli, Wang Qi, Ren Hengchang,Xu Rubin, YuWenli*.Protective effect of ulinastatin combined with dexmedetomidine onlung injury after cold ischemia-reperfusion in rats. EurRev Med Pharmacol Sci. 2018,22;17:5712-5718. (通讯作者,IF=1.981)

  10. Sun Ying,Jia Lili, YuWenli*,Yu Hongli, Sheng Mingwei, Du Hongyin. The changes of intraoperativebody temperature in adult liver transplantation:A retrospective study. HepatobiliaryPancreat Dis Int. 2018,29.(通讯作者,IF=1.72)

  11. Yuanbang LinMingwei ShengYijie DingNan ZhangYayue SongHongyin DuNing Lu*Wenli Yu*.Berberine protects renal tubular cells against hypoxia/reoxygenationinjury via the Sirt1/p53 pathway. JNat Med. 2018,72;3:715-723.(共同通讯作者,IF=1.83)

  12. JinyuanLi, Gang Wang, Weituan Xu, Mei Ding, WenliYu*.Efficacy of intravenous lidocaine on pain relief in patientsundergoing laparoscopic cholecystectomy: A meta-analysis fromrandomized controlled trials.IntJ Surg. 2018,2;50:137-145. (通讯作者,IF=2.728)

  13. Yongwang Wang,Qingping Wang, WenliYu*,Hongyin Du. CrocinAttenuates Oxidative Stress and Myocardial Infarction Injury inRats.IntHeart J. 2018,59;2:387-393. (通讯作者,IF=1.695)

  14. XiaoDanLi, Chao Han, WenliYu*.Isgabapentin effective and safe in open hysterectomy? A PRISMAcompliant meta-analysis of randomized controlled trials.JClin Anesth. 2017,41:76-83. (通讯作者,IF=1.852)

  15. WeihuaLiu, WenliYu*,Yiqi Weng, Yongwang Wang, Mingwei Sheng. Dexmedetomidine amelioratesthe inflammatory immune response in rats with acute kidney damage.ExpTher Med. 2017,14;4:3602-3608.(通讯作者,IF=1.403)

  16. Yiwei Shi,Gang Wang, Jinyuan Li, WenliYu*.Hydrogen gas attenuates sevoflurane neurotoxicity through inhibitingnuclear factor κ-light-chain-enhancer of activated B cellssignaling and proinflammatory cytokine release in neonatal rats.Neuroreport. 2017, 28;17:1170-1175. (通讯作者,IF=1.493)

  17. ZhuMin, Yuan Shaoting, YuWenli*,Jia Lili, Sun Ying, CXCL13 regulates the trafficking ofGluN2B-containing NMDA receptor via IL-17 in the development ofremifentanil-induced hyperalgesia in rats. Neurosci Lett. 2017, 28;648:26-33. (通讯作者,IF=2.124)

  18. LinYuanbang, Sheng Mingwei, Weng Yiqi, Xu Rubin, Lu Ning, Du Hongyin,YuWenli*,Berberine protects against ischemia/reperfusion injury afterorthotopic liver transplantation via activating Sirt1/FoxO3alphainduced autophagy. Biochem Biophys Res Commun. 2017, 483;2:885~891.(通讯作者,IF=2.455)

  19. ShengMing, Lin Yuanbang, Weng Yiqi, Xu Rubin, Sun Ying, YuWenli*,Du Hongyin*,Predictive Value of Intraoperative Troponin I Elevation in PediatricLiving Donor Liver Transplant Recipients with Biliary Atresia.Transplantation. 2017, 101; 10 : 2358-2390. (共同通讯作者,IF=3.786)

  20. JiaLili, Wang Fei, Gu Xiangqian, Weng Yiqi, Sheng Mingwei, Wang Gang,Li Shipeng, Du Hongyin, YuWenli*,Propofol postconditioning attenuates hippocampusischemia-reperfusion injury via modulating JAK2/STAT3 pathway inrats after autogenous orthotropic liver transplantation. Brain Res.2017,15; 1657:202-207. (通讯作者,IF=2.929)

  21. XuWeituan, Zhu Ming, Yuan Shaoting, YuWenli*,Spinal CXCL5 contributes to nerve injury-induced neuropathic painvia modulating GSK-3β phosphorylation and activity in rats.Neurosci Lett. 2016, 634: 52~59. (通讯作者,IF=2.124)

  22. DuHongyin, Sheng Mingwei, Wu Li, Zhang Yamin, Shi Dongjin, Weng Yiqi,Xu Rubin, YuWenli*,Hydrogen-Rich Saline Attenuates Acute Kidney Injury After LiverTransplantation via Activating p53-Mediated Autophagy.Transplantation.2016,100; 3: 563-570. (通讯作者,IF=3.786)

荣誉和奖励

12020年,儿童肝移植围术期心脑肾功能保护策略的建立与应用,第1完成人,天津市科技进步三等奖

22018年,天津市第一中心医院麻醉科,天津市临床重点培育学科,学科带头人

32016年,肝移植围术期远隔脏器损伤防治策略的建立与应用,第2完成人,天津市科技进步二等奖,2016JB-2-043-R2

42009年,经典非转流肝移植术中氧代谢的临床研究,第4完成人,天津市科技进步三等奖2009JB-3-186-R4

、联系方式

Tel:13920098326

Email:yzxyuwenli@163.com