严颖彬


 姓名:严颖彬

 职称:主任医师

 导师类型:博士研究生导师

 一、教育经历

 1. 1998.7-2003.6,中国医科大学口腔系,本科/学士

 2. 2003.7-2006.6,北京大学口腔医学院口腔颌面外科,研究生/口腔医学硕士

 3. 2008.9-2011.6,北京大学口腔医学院口腔颌面外科,研究生/医学博士

 二、工作经历

 (写主要工作经历)

 2006年7月-2008年8月,天津市口腔医院口腔颌面外科,住院医师;

 2011年7月-2013年11月,天津市口腔医院口腔颌面外科,主治医师;

 2013年12月-2017年12月,天津市口腔医院口腔颌面外科,副主任医师;

 2018年1月至今,天津市口腔医院口腔颌面头颈肿瘤科,主任医师,科室副主任。

 三、研究方向(包括承担课题项目)

 研究方向为口腔颌面头颈肿瘤与缺损修复重建、口腔颌面创伤。在口腔癌的手术治疗、颈淋巴清扫、各种肌皮骨瓣修复颌面颈部软组织及颌骨缺损、颅颌面复杂陈旧性骨折、下颌骨高位髁突骨折及颞下颌关节外科等方面有丰富的临床经验。擅长显微外科技术、3D打印技术辅助下的上下颌骨重建术。在研课题两项:1. 津门医学英才项目(2023.8-2026.8),120

 ,主持;2.基于增强线粒体与内质网相互作用诱导口腔癌细胞免疫原性死亡的新型药物研发及抗癌机制研究(2015.1-2017.12),天津市教委科研计划项目(南开大学医学融合专项,2024ZXZD012),20万,主持。

 四、学术兼职

国家口腔医学中心口腔颌面外科专科联盟专家委员会委员、中华口腔医学会口腔颌面头颈肿瘤专委会委员、中华口腔医学会口腔颌面外科专委会委员、中华口腔医学会口腔颌面创伤及正颌专委会常委、中国医药教育协会头颈肿瘤专委会常委、中国抗癌协会口腔颌面肿瘤整合康复专委会委员、天津市口腔医学会常务理事、天津市口腔医学会口腔颌面外科专委会副主委、天津市医学会显微外科分会常委、天津市抗癌协会头颈肿瘤专委会常委、天津市康复医学会修复重建外科专委会常委

 五、近五年发表的学术论文

 1. Zhang TM, Yang K, Jiao MN, Zhao Y, Xu ZY, Zhang GM, Wang HL, Liang SX*, Yan YB*. Temporal gene expression profiling during early-stage traumatic temporomandibular joint bony ankylosis in a sheep model. BMC Oral Health. 2024;24(1):284. (通讯作者, IF=2.9)

 2. Shang JW, Tian YY, Xu ZY, Liu XM, Cao Y, Sui L, Mao C, Zhou YS, Liu CL*, Ye HQ*, Yan YB* et al: Validation of the "obturator functioning scale" for Chinese-speaking patients with obturator prostheses after cancer-related maxillectomy. Heliyon 2024, 10(10):e31071. (通讯作者, IF=3.4)

 3. Zhang TM, Jiao MN, Yang K, Wang HL, Zhang CS, Wang SH, Zhang GM, Miao HJ, Shen J*, Yan YB*: YAP promotes the early development of temporomandibular joint bony ankylosis by regulating mesenchymal stem cell function. Sci Rep 2024, 14(1):12704. (通讯作者, IF=3.8)

 4. Wang SH, Wang SR, Luan NN, Sun XQ, Guo YR, Yan YB*, Liang SX*: Wnt/Ca(2+) pathway inhibits neural differentiation of human dental pulp stem cells in vitro. J Dent Sci 2024, 19(4):2090-2099. (通讯作者, IF=3.4)

 5. Xu ZY, Han J, Yang K, Zhang GM, Jiao MN, Liang SX, Yan YB*, Chen W*. HSP27 promotes vasculogenic mimicry formation in human salivary adenoid cystic carcinoma via the AKT-MMP-2/9 pathway. Oral Surg Oral Med Oral Pathol Oral Radiol. 2024. https://doi.org/10.1016/j.oooo.2024.02.016. (通讯作者, IF=2.9)

 6. Chen H, Bao P, Lv Y, Luo R, Deng J*, Yan Y*, Ding D*, Gao H*. Enhancing NIR-II Imaging and Photothermal Therapy for Improved Oral Cancer Theranostics by Combining TICT and Aggregation-Induced Emission. ACS Appl Mater Interfaces. 2023 Nov 29.doi: 10.1021/acsami.3c14905. Online ahead of print. (通讯作者, IF=9.5)

 7. He-Jing Miao, Shao-Kang Sun, Yuan-Yuan Tian, Yun-Qi Yang, Shi-Hua Wang, Shuang Bai, Wei Chen, Chi Mao, Su-Xia Liang, Ying-Bin Yan*. Oncologic safety of the pedicled submental island flap for reconstruction in oral tongue squamous cell carcinoma: An analysis of 101 cases. Oral Oncol. 2023 May;140:106395. doi: 10.1016/j.oraloncology.2023.106395. (通讯作者, IF=5.9)

 8. Shiyu Liu, Fan Li, Li Deng, Qiongqiong Ma, Wenyi Lu, Zhouqian Zhao, Huanzhen Liu, Yixuan Zhou, Manli Hu, Hui Wang, Yingbin Yan*, Mingfeng Zhao*, Hongkai Zhang*, Mingjuan Du*. Claudin18.2 Bispecific T Cell Engager Armed Oncolytic Virus Enhances Anti-tumor Effects Against Pancreatic Cancer. Mol Ther Oncolytics. 2023 Aug 24:30:275-285.(通讯作者, IF=5.7)

 9. Ye K, Li F, Wang RK, Cen TY, Liu SY, Zhao GQ, Li RN, Xu LL, Zhang GM, Xu ZY, Deng L, Li LL, Wang W, Alexey Stepanov, Wang YJ, Guo Y, Li YK, Yang W, Tian YJ, Alexander G Gabibov, Yan YB*, Zhang HK*. An armed oncolytic 1 virus enhances the efficacy of tumor-infiltrating lymphocyte therapy by converting tumors to artificial antigen presenting cells in situ. Mol Ther. 2022;30(12):3658-3676.doi:10.1016/j.ymthe.2022.06.010.(通讯作者, IF=12.4)

 10. Fan YR, Li FJ, Zou HR, Xu ZY, Liu H, Luo R, Zhang GM, Li RX*, Yan YB*, Liu H*. Photothermal effect of indocyanine green modified scaffold inhibits oral squamous cell carcinoma and promotes wound healing. Biomater Adv. 2022;137:212811. https://doi.org/10.1016/j.bioadv.2022.212811.(通讯作者, IF=8.5)

 11. Zhang GM, Jiao D, Nie SC, Xu ZY, Zhang X, Dai Y, Jiao MN, Ou LH*, Yan YB*, Ding D*. Near-infrared aggregation-induced emission nanodots for early diagnosis of tongue squamous cell carcinoma and sentinel lymph node mapping. Biomater Sci. 2022;10:1929-35.(通讯作者,IF=7.6)

 12. Li-Mei Wang, Yuan-Yuan Tian, Xiao-ming Liu, Ye Cao, Lei Sui Chi Mao, Hao Liu, Jia-Hui Ye, Yong-Sheng Zhou, Xin Peng,*, Hong-Qiang Ye*, Ying-Bin Yan*. Quality of life in patients with cancer-related Brown IIb maxillary defect: A comparison between conventional obturation rehabilitation and submental flap reconstruction. Oral Oncol. 2022 Sep;132:105980.doi: 10.1016/j.oraloncology.2022.105980. (通讯作者, IF=5.9)

 13. Zhang GM, Nie SC, Xu ZY, Fan YR, Jiao MN, Miao HJ, Liang SX*, Yan YB*. Advanced Polymeric Nanoagents for Oral Cancer Theranostics: A Mini Review. Front Chem. 2022;10:927595. doi: 10.3389/fchem.2022.927595.(通讯作者, IF=5.5)

 14. Nie SC, Yang K, Luan NN, Lian XL, Dai XH, Liang SX*, Yan YB*. Unveiling the Differences in Biological Properties of Dental Pulp Stem Cells from Normal and Inflamed Pulp: A Comprehensive Comparative Study. Med Sci Monit. 2022;28:e934511. doi: 10.12659/MSM.934511.(通讯作者, IF=3.4)

 15. Liang SX, Fang H, Chen W, Yan YB*. Expression of Cancer-testis Antigens in Adenoid Cystic Carcinoma of the Salivary Glands Correlates with Clinical Outcomes [J]. J Hard Tissue Biol. 2021, 30(3): 283-290.(通讯作者, IF=0.6)

 16. Jiao MN, Zhang TM, Yang K, Xu ZY, Zhang GM, Tian YY, Liu H, Yan YB*. Absorbance or organization into ankylosis: a microarray analysis of haemarthrosis in a sheep model of temporomandibular joint trauma. BMC Oral Health. 2021;21:668.(通讯作者, IF=3.7)

 17. Zhang TM, Yang K, Liang SX, Tian YY, Xu ZY, Liu H, Yan YB*. Microarray Analysis of Differential Gene Expression Between Traumatic Temporomandibular Joint Fibrous and Bony Ankylosis in a Sheep Model. Med Sci Monit. 2021 Aug 17;27:e932545.(通讯作者, IF=3.4)

 18. Zhang PP, Liang SX, Wang HL, Yang K, Nie SC, Zhang TM, Tian YY, Xu ZY, Chen W, Yan YB*. Differences in the biological properties of mesenchymal stromal cells from traumatic temporomandibular joint fibrous and bony ankylosis: a comparative study. Anim Cells Syst (Seoul).2021 Sep 28;25(5):296-311.(通讯作者, IF=2.4)

 六、荣誉和奖励

 主持国家自然科学基金1项、天津市自然科学基金1项、天津市卫健委及天津市教委等基金项目3项。以第一或通讯作者发表论文40余篇,其中SCI收录31篇。多篇论文发表在Mol Ther、Oral Oncol、Biomater Adv、ACS Appl Mater Interfaces等权威期刊。参编五年制统编教材《口腔颌面外科学》(人民卫生出版社,第九版)、参与翻译专著《口腔颌面创伤》(人民卫生出版社,2017年)、头颈口面部感染(人民卫生出版社,2023年)。入选天津市“131人才”第一层次(2017年)、“津门医学英才”(2023年)、天津市医学重点学科口腔颌面外科学后备学科带头人。

 七、联系方式

Yingbinyan@qq.com