本人照片

姓名：郭雅图

职称：副主任医师

导师类型：硕士研究生导师

1. 教育经历

2002.9-2007.7山西医科大学临床医疗系学士学位

2007.9-2012.7天津医科大学研究生院 硕博连读 博士研究生

2011.9-2012.3Johns Hopkins University Joint Ph.D

2. 工作经历

2012.9-2013.9 天津市眼科医院住院医师

2013.9-2019.12天津市眼科医院主治医师

2019.12-至今 天津市眼科医院 副主任医师

3. 研究方向（可以填写多个方向）

1. 临床应用研究：眼外肌病的眼外肌结构及功能性改变；斜视弱视患者及特殊人群患者皮层认知功能性改变；成人弱视的治疗

2. 基础应用研究：

A.儿童青少年视觉发育及斜弱视的神经电生理机制及应用转化

B.胶质细胞，亚板神经元在视觉发育及信息处理中作用

C.儿童相关眼病的脑肠轴与眼肠轴关系及干预手段；

D.氧化还原型物质在ROP及儿童眼病中的应用

4. 学术兼职

天津市医学会青年委员会委员

天津市医学会眼科学分会视觉生理学组委员

天津市医学会眼科学分会眼视光学组 委员

天津市医学会医疗健康学会食品与健康学组委员

5. 代表性学术论文

1. GuoY,Zhang H, Chen X, Yang X, Cheng W, Zhao K. Association of TP53polymorphisms with primary open-angle glaucoma: a meta-analysis.Invest Ophthalmol Vis Sci. 2012 2012-06-20;53(7):3756-63.

2. GuoY,Huang S, de Pasquale R, McGehrin K, Lee HK, Zhao K, et al. Darkexposure extends the integration window for spike-timing-dependent plasticity. J NEUROSCI. 2012 2012-10-24;32(43):15027-35.

3. HuangS, Treviño M, He K, Ardiles A, Pasquale R, GuoY,et al. Pull-push neuromodulation of LTP and LTD enables bidirectionalexperience-induced synaptic scaling in visual cortex. NEURON. 20122012-02-09;73(3):497-510.

4. GuoY,Chen X, Zhang H, Li N, Yang X, Cheng W, et al. Association of OPA1polymorphisms with NTG and HTG: a meta-analysis. PLOS ONE. 20122012-01-20;7(8):e42387.

5. GuoY,Zhao K. [The developmental switch of visual cortex NMDA receptor NR2subunits and its implications for visual plasticity]. Zhonghua YanKe Za Zhi. 2015 2015-06-01;51(6):470-6.

6. GuoY,Zhang W, Chen X, Fu J, Cheng W, Song D, et al. Timing-dependent LTPand LTD in mouse primary visual cortex following different visualdeprivation models. PLOS ONE. 2017 2017-01-20;12(5):e176603.

7. CaoX,Guo Y,Wang Y, Wang H, Liu D, Gong Y, et al. Effects of high-fat diet andApoe deficiency on retinal structure and function in mice. Sci Rep.2020 2020-11-02;10(1):18601.

8. GongY, Wang X, Wang Y, Hao P, Wang H, GuoY,et al. The effect of a chrysanthemum water extract in protecting theretina of mice from light damage. BMC Complement Med Ther. 20222022-08-26;22(1):224.

9. LiY, Li HX, Liu YC, GuoYT,Gao JM, Wu B, et al. Comparison of immersion ultrasound and lowcoherence reflectometry for ocular biometry in cataract patients.Int J Ophthalmol. 2018 2018-01-20;11(6):966-9.

10. WangH, Wang J, Liu Y, Ji Y, GuoY,Zhao J. Interaction mechanism of carnosic acid against glycosidase(α-amylase and α-glucosidase). INT J BIOL MACROMOL. 20192019-10-01;138:846-53.

11. ChengJ, Liu Y, Liu Y, Liu D, Liu Y, Guo Y, et al. Ursolic acid alleviateslipid accumulation by activating the AMPK signaling pathway in vivoand in vitro. J FOOD SCI. 2020 2020-11-01;85(11):3998-4008.

12. WangH, Yan Y, Feng X, Wu Z,Guo Y,Li H, et al. Improved physicochemical stability of emulsions enrichedin lutein by a combination of chlorogenic acid-whey proteinisolate-dextran and vitamin E. J FOOD SCI. 20202020-10-01;85(10):3323-32.

13. WangH, Liu D, Ji Y, Liu Y, Xu L, GuoY.Dietary Supplementation of Black Rice Anthocyanin Extract RegulatesCholesterol Metabolism and Improves Gut Microbiota Dysbiosis inC57BL/6J Mice Fed a High-Fat and Cholesterol Diet. MOL NUTR FOODRES. 2020 2020-04-01;64(8):e1900876.

14. HanY, GuoY,Cui SW, Li H, Shan Y, Wang H. Purple Sweet Potato Extract extendslifespan by activating autophagy pathway in male Drosophilamelanogaster. EXP GERONTOL. 2021 2021-02-01;144:111190.

15. TianL, GuoYT,Ying M, Liu YC, Li X, Wang Y. Co-existence of myopia and amblyopia ina guinea pig model with monocular form deprivation. Ann Transl Med.2021 2021-01-01;9(2):110.

16. LiuY, Liu Y, GuoY,Xu L, Wang H. Phlorizin exerts potent effects against aging inducedby D-galactose in mice and PC12 cells. FOOD FUNCT. 20212021-03-15;12(5):2148-60.

17. ZhangX, Wang H, Han Y, Pei Y, Guo Y, Cui SW. Purple sweet potato extractmaintains intestinal homeostasis and extend lifespan throughincreasing autophagy in female Drosophila melanogaster. J FOODBIOCHEM. 2021 2021-07-15:e13861.

18. LiuD, Ji Y,Guo Y,Wang H, Wu Z, Li H, et al. Dietar1111111983111采集11 19830808ySupplementation of Apple Phlorizin Attenuates the Redox State Relatedto Gut Microbiota Homeostasis in C57BL/6J Mice Fed with a High-FatDiet. J Agric Food Chem. 2021 2021-01-13;69(1):198-211.

19. LiuD, Ji Y, Wang K, GuoY,Wang H, Zhang H, et al. Purple sweet potato anthocyanin extractregulates redox state related to gut microbiota homeostasis in obesemice. J FOOD SCI. 2022 2022-05-01;87(5):2133-46.

6. 荣誉和奖励

天津市第三批人才发展特殊支持计划—青年拔尖人才

天津市卫生健康行业高层次人才选拔培养工程青年医学新锐

天津市眼科医院人才分层次培养青年创新优秀人才

7. 联系方式

联系邮箱：yatuguo@163.com;yatu.guo@gmail.com

联系地址：天津市和平区甘肃路4号