本人照片

姓名：王凤梅

职称：教授、主任医师

导师类型：博士研究生导师

1. 教育经历

2016.08—2016.09美国约翰霍普金斯医院进修；

2012.08—2012.09台湾辅仁大学进修；

2007.09—2011.06：天津医科大学中西医结合临床专业，研究方向为慢性肝炎转化为早期肝癌的微环境研究，医学博士；

2001.09—2004.06：天津医科大学临床医学专业，肝癌的个体化综合治疗，医学硕士专业学位；

1987.09—1992.06：山东大学医学院医学系，学士学位

2. 工作经历

2020.12至今天津市第三中心医院院长、党委副书记

2019.8.12—2020.12天津市第二人民医院院长，党委副书记

2015.8—2019.8.11天津市第三中心医院副院长

2013.09—2019.4天津市第三中心医院消化肝病科主任

2012.10—2019.08天津市第三中心医院消化科主任医师

2004—2012.10天津市第三中心医院肝内科副主任医师

1992.07—2001 年天津市第三中心医院消化内科、急救内科、肝病内科医师、主治医师

3. 研究方向（可以填写多个方向）

1肝脏病学

2肝脏炎癌早筛早诊综合治疗新技术研究

3肝衰竭诊治新技术研究

4门脉高压全过程管理的新技术研究

4. 学术兼职

1. 中华医学会肝病学分会青年委员

2. 中华医学会消化病学分会肝胆学组委员

3. 天津市医学会消化病学分会主任委员

4. 天津市医学会第八届理事会常务理事

5. 代表性学术论文

1. Wang F, Zhang Y, Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, Zong WX. The Ubiquitin E3 Ligase TRIM21 Promotes Hepatocarcinogenesis by Suppressing the p62-Keap1-Nrf2 Antioxidant Pathway. Cell Mol Gastroenterol Hepatol. 2021;11(5):1369-1385. doi: 10.1016/j.jcmgh.2021.01.007. Epub 2021 Jan 19. PMID: 33482392; PMCID: PMC8024979.

2. Zheng KI, Liu C, Li J, Zhao L, Zheng MH, Wang F, Qi X. Validation of Baveno VI and expanded Baveno VI criteria to identify high-risk varices in patients with MAFLD-related compensated cirrhosis. J Hepatol. 2020 Dec;73(6):1571-1573. doi: 10.1016/j.jhep.2020.06.042. Epub 2020 Sep 21. PMID: 32972730.

3. Xia H, Zhang Y, Zaongo SD, Liang J, Gong X, Hu Y, Ma P, Wang F. Direct-acting antiviral treatments display excellent outcomes even in older HCV-infected patients at increased risk of fibrosis. Ann Transl Med. 2021 May;9(10):847. doi: 10.21037/atm-21-1297. PMID: 34164481; PMCID: PMC8184475.

4. Jin X, Wang J, Zou S, Xu R, Cao J, Zhang Y, Guo J, Wen X, Deng S, Zheng Y, Zhu Y, Wang F, Xu Z. Cinobufagin Triggers Defects in Spindle Formation and Cap-Dependent Translation in Liver Cancer Cells by Inhibiting the AURKA-mTOR-eIF4E Axis. Am J Chin Med. 2020;48(3):651-678. doi: 10.1142/S0192415X20500330. Epub 2020 Apr 30. PMID: 32349518.

5. Jiang B, Su R, Ren D, Zheng X, Cao Y, Mi Y, Wang F, Ma P. Evaluation of HBV serological markers in treatment-naïve HBV mono-infected patients and HBV-HIV co-infected patients. Virus Res. 2020 Dec;290:198117. doi: 10.1016/j.virusres.2020.198117. Epub 2020 Aug 13. PMID: 32800804.

6. Zhu P, Ye Q, Li TH, Han T, Wang FM. Hemophagocytic lymphohistiocytosis complicated by polyserositis: A case report. World J Clin Cases. 2019 Oct 6;7(19):3069-3073. doi: 10.12998/wjcc.v7.i19.3069. PMID: 31624756; PMCID: PMC6795728.

7. Zhao L, Fu L, Xu Z, Fan R, Xu R, Fu R, Zou S, Wang C, Zhang Y, Wang J, Bao J, Wang Z, Hou X, Zheng Y, Dai E, Wang F. The anticancer effects of cinobufagin on hepatocellular carcinoma Huh7 cells are associated with activation of the p73 signaling pathway. Mol Med Rep. 2019 May;19(5):4119-4128. doi: 10.3892/mmr.2019.10108. Epub 2019 Mar 29. PMID: 30942456; PMCID: PMC6471725.

8. Wang F, Lv H, Li Y, Han T, Liu H, Jia K, Liu F, Gao Y, Wang F. Complete cure of a patient with HBV-associated hepatocellular carcinoma with lung metastasis using interferon and survival up to 108 months: A case report and literature review. Oncol Lett. 2018 Sep;16(3):2979-2988. doi: 10.3892/ol.2018.9033. Epub 2018 Jun 28. PMID: 30127887; PMCID: PMC6096095.

9. Liang J, Liu F, Wang F, Han T, Jing L, Ma Z, Gao Y. A Noninvasive Score Model for Prediction of NASH in Patients with Chronic Hepatitis B and Nonalcoholic Fatty Liver Disease. Biomed Res Int. 2017;2017:8793278. doi: 10.1155/2017/8793278. Epub 2017 Mar 2. PMID: 28349067; PMCID: PMC5352864.

10. Zhou Y, Xu X, Ding J, Jing X, Wang F, Wang Y, Wang P. Dynamic changes of T-cell subsets and their relation with tumor recurrence after microwave ablation in patients with hepatocellular carcinoma. J Cancer Res Ther. 2018 Jan;14(1):40-45. doi: 10.4103/jcrt.JCRT_775_17. PMID: 29516957.

11. Yin W, Ye Q, Wang F, Liang J, Xu B, Zhang X, Zhang Q, Liu Y, Li G, Han T. ART score and hepatocellular carcinoma: An appraisal of its applicability. Clin Res Hepatol Gastroenterol. 2016 Dec;40(6):705-714. doi: 10.1016/j.clinre.2016.05.005. Epub 2016 Jun 8. PMID: 27289168.

12. Xu Z, Wang F, Fan F, Gu Y, Shan N, Meng X, Cheng S, Liu Y, Wang C, Song Y, Xu R. Quantitative Proteomics Reveals That the Inhibition of Na(+)/K(+)-ATPase Activity Affects S-Phase Progression Leading to a Chromosome Segregation Disorder by Attenuating the Aurora A Function in Hepatocellular Carcinoma Cells. J Proteome Res. 2015 Nov 6;14(11):4594-602. doi: 10.1021/acs.jproteome.5b00724. Epub 2015 Oct 22. PMID: 26491887.

13. Liu H, Li J, Wang F, Gao Y, Luo Y, Wang P, Li C, Zhu Z. Comparative study of different procedures for the separation of peripheral blood mononuclear cells in cytokine-induced killer cell immunotherapy for hepatocarcinoma. Tumour Biol. 2015 Apr;36(4):2299-307. doi: 10.1007/s13277-014-2837-5. Epub 2014 Nov 24. PMID: 25417201.

14. Huang Y, Wang F, Wang Y, Zhu Z, Gao Y, Ma Z, Xu R, Du Z. Intrahepatic interleukin-17+ T cells and FoxP3+ regulatory T cells cooperate to promote development and affect the prognosis of hepatocellular carcinoma. J Gastroenterol Hepatol. 2014 Apr;29(4):851-9. doi: 10.1111/jgh.12418. PMID: 24303990.

15. Huang Y, Liao H, Zhang Y, Yuan R, Wang F, Gao Y, Wang P, Du Z. Prognostic value of tumor-infiltrating FoxP3+ T cells in gastrointestinal cancers: a meta analysis. PLoS One. 2014 May 14;9(5):e94376. doi: 10.1371/journal.pone.0094376. PMID: 24827118; PMCID: PMC4020764.

16. Wang F, Jing X, Li G, Wang T, Yang B, Zhu Z, Gao Y, Zhang Q, Yang Y, Wang Y, Wang P, Du Z. Foxp3+ regulatory T cells are associated with the natural history of chronic hepatitis B and poor prognosis of hepatocellular carcinoma. Liver Int. 2012 Apr;32(4):644-55. doi: 10.1111/j.1478-3231.2011.02675.x. Epub 2011 Nov 28. PMID: 22118340.

17. Wang F, Jing X, Wang T, Li G, Li T, Zhang Q, Huang Y, Li J, Wang Y, Gao Y, Han T, Du Z. Differential diagnostic value of GPC3-CD34 combined staining in small liver nodules with diameter less than 3 cm. Am J Clin Pathol. 2012 Jun;137(6):937-45. doi: 10.1309/AJCP0KZZ5DSIGMNY. PMID: 22586053.

18. Ding J, Jing X, Liu J, Wang Y, Wang F, Wang Y, Du Z. Comparison of two different thermal techniques for the treatment of hepatocellular carcinoma. Eur J Radiol. 2013 Sep;82(9):1379-84. doi: 10.1016/j.ejrad.2013.04.025. Epub 2013 May 28. PMID: 23726122.

19. Shan SG, Gao YT, Xu YJ, Huang Y, Zhang Q, Zhai DK, Li JB, Wang FM, Jing X, Du Z, Wang YJ. Gradually increased Golgi protein 73 expression in the progression of benign liver diseases to precancerous lesions and hepatocellular carcinoma correlates with prognosis of patients. Hepatol Res. 2013 Nov;43(11):1199-210. doi: 10.1111/hepr.12078. Epub 2013 May 10. PMID: 23607749.

20. Huang Y, Wang FM, Wang T, Wang YJ, Zhu ZY, Gao YT, Du Z. Tumor-infiltrating FoxP3+ Tregs and CD8+ T cells affect the prognosis of hepatocellular carcinoma patients. Digestion. 2012;86(4):329-37. doi: 10.1159/000342801. Epub 2012 Nov 28. PMID: 23207161.

21. Zhang Y, Yang B, Du Z, Bai T, Gao YT, Wang YJ, Lou C, Wang FM, Bai Y. Aberrant methylation of SPARC in human hepatocellular carcinoma and its clinical implication. World J Gastroenterol. 2012 May 7;18(17):2043-52. doi: 10.3748/wjg.v18.i17.2043. PMID: 22563191; PMCID: PMC3342602.

22. Xu ZW, Wang FM, Gao MJ, Chen XY, Shan NN, Cheng SX, Mai X, Zala GH, Hu WL, Xu RC. Cardiotonic steroids attenuate ERK phosphorylation and generate cell cycle arrest to block human hepatoma cell growth. J Steroid Biochem Mol Biol. 2011 Jul;125(3-5):181-91. doi: 10.1016/j.jsbmb.2010.12.016. Epub 2011 Jan 6. PMID: 21215801.

23. Xu ZW, Wang FM, Gao MJ, Chen XY, Hu WL, Xu RC. Targeting the Na(+)/K(+)-ATPase alpha1 subunit of hepatoma HepG2 cell line to induce apoptosis and cell cycle arresting. Biol Pharm Bull. 2010;33(5):743-51. doi: 10.1248/bpb.33.743. PMID: 20460749.

24. Gao YT, Han T, Li Y, Yang B, Wang YJ, Wang FM, Jing X, Du Z. Enhanced specificity of real-time PCR for measurement of hepatitis B virus cccDNA using restriction endonuclease and plasmid-safe ATP-dependent DNase and selective primers. J Virol Methods. 2010 Oct;169(1):181-7. doi: 10.1016/j.jviromet.2010.07.031. Epub 2010 Aug 5. PMID: 20691734.

25. 乔坤艳,张世田,苏瑞,侯伟,王凤梅.DEPDC5 rs5998152单核苷酸多态性与丙型肝炎病毒相关疾病发生风险的相关性分析[J].中华实验和临床病毒学杂志,2021,35(03):300-304.

26. 乔坤艳,苏瑞,蒋贝,王凤梅.RNA m6A修饰参与乙型和丙型肝炎病毒复制及相关肝癌发生机制研究进展[J].中华实验和临床病毒学杂志,2021,35(02):237-241.

27. 刘师伟,梁静,唐飞,刘华,刘磊,刘芳,王凤梅.人工肝支持系统与糖皮质激素治疗重度急性药物性肝损伤的疗效[J].天津医药,2021,49(07):723-726.

28. 周燕,李丹,龙磊,丁建民,王凤梅,王彦冬,周洪雨,经翔.混合型肝癌的增强模式分析及超声造影联合增强CT/MRI及肿瘤标志物的诊断价值[J].中华超声影像学杂志,2020,29(09):754-760.

29. 唐飞,王凤梅,吕洪敏,王芳,哈福双.IL-6、 hs-CRP及Hsp70诊断肝硬化患者幽门螺杆菌感染的价值[J].中华医院感染学杂志,2020,30(16):2416-2420.

6. 荣誉和奖励

1.2022.02 天津市科学技术进步二等奖

2.2020年荣获全国抗击新冠肺炎疫情先进个人称号

3.2020年荣获天津市劳动模范称号

4.2020年荣获天津市优秀共产党员

5.2020年享受国务院政府特殊津贴

6.首届天津名医

7.天津市最美科技工作者

8.2018年获天津市三八红旗手

9.2016年荣获天津市五一劳动奖章

10.2008年获天津医科大学优秀教师奖

11.2003年获天津市抗击非典先进标兵

7. 联系方式

联系邮箱：wangfengmei@nankai.edu.cn

联系地址：天津市河东区津塘路83号