姓名：张锡朋

职称：主任医师

导师类型：博士研究生导师

1. 教育经历

1980.09-1985.07，天津医科大学，临床医学，学士

2. 工作经历

1985.07-1992.05，天津市滨江医院，住院医师

1992.06-2000.05，天津市滨江医院，主治医师

2000.06-2003.04，天津市滨江医院，副主任医师

2003.05-2004.05，天津市人民医院，副主任医师

2004.06-2005.05，天津市人民医院，副主任医师、科主任

2005.06-2013.05，天津市人民医院，主任医师、科主任

2013.06-2016.05，天津市人民医院，主任医师、科主任、中心主任

2016.06至今，天津市人民医院，主任医师、科主任、中心主任、肛研所所长

3. 研究方向（可以填写多个方向）

研究方向：结直肠恶性肿瘤的防治及相关分子机制

承担天津市临床重点专科建设项目（二期建设经费300万）、天津市人民医院-南开大学联合项目（60万）等学科建设及科研项目。

承担及参与相关课题：

1.天津市科委多元投入基金项目重点项目，p53基因型调控不同磷酸化位点CDC25C表达及亚细胞定位与多倍体肿瘤巨细胞形成，2021-2024，40

；

2.天津市科委慢性病防治科技重大专项，17ZXMFSY00120，结直肠癌患者术后转移预测的早期诊断和防治策略，2017/10-2020/9，50

3.天津市卫计委中医中西医结合科研课题，2015067，冲和膏对痔组织微循环的影响及意义，2015/10-2017/09，4

4.天津市卫计委重点攻关项目，14KG108，结直肠恶性肿瘤生物样本库的构建与管理，2015/01-2017/12，20

5.天津市科委抗癌重大专项攻关计划，12ZCDZSY17100，结直肠癌早期诊断及治疗的临床研究，2012/04-2015/03，50

6.中国医师协会临床科研专项资金，DC疫苗联合CIK细胞治疗在CRC规范化治疗后的应用，2012/07-2014/07，3

7.天津市卫计委重点项目，06KR10，大肠癌与高胰岛素血症的相关性研究，2006/04-2008/03，4

4. 学术兼职

中国中西医结合学会大肠肛门病专业委员会副主任委员

中国医师协会结直肠肿瘤专业委员会常务委员

中国抗癌学会大肠癌专业委员会委员

中国医师协会中西医结合委员会肛肠专家委员会委员

中国医师协会微创外科专业委员会委员

国家癌症中心结直肠癌质控专家委员会委员

京津冀大肠癌医师联盟副主任委员

天津市中西医结合学会大肠肛门病专业委员会主任委员

天津市医学会肿瘤学会委员

《中国肛肠病杂志》编委，Bioengineered、CancerBiology & Therapy、WorldJournal of Surgical Oncology、Frontiersin Genetics等杂志审稿人

5. 代表性学术论文

[1] ZhangM, Zhao L, Zhang Y, Jing H, Wei L, Li Z, Zhang H, Zhang Y, Zhu S,Zhang S, Zhang X. Colorectal Cancer Screening With High Risk-FactorQuestionnaire and Fecal Immunochemical Tests Among 5,947,986Asymptomatic Population: A Population-Based Study. Front Oncol.2022;12:893183.

[2] ZhangM, Zhang Y, Jing H, Zhao L, Xu M, Xu H, Zhu S, Zhang X. Prognosis ofPatients Over 60 Years Old With Early Rectal Cancer UndergoingTransanal Endoscopic Microsurgery - A Single-Center Experience. FrontOncol. 2022;12:888739.

[3] SunY, Yang H, Zhang Z, Zhou Y, Li P, Zeng Q, Zhang X. A novel surgicalapproach in dealing with the confusing sites in total mesorectalexcision: fascial space priority approach with two tunnelsestablished. Tech Coloproctol.2022.2；26(2):153-154

[4] SunY, Yang H, Zhang Z, Zhou Y, Li P, Zeng Q, Fu W, Zhang X. LaparoscopicPelvic Exenteration with Bladder Sparing for Men with LocallyAdvanced Rectal Cancer (with Video). Ann Surg Oncol. 2022May;29(5):3067-3068.

[5] SunY, Yang H, Zhang Z, Li J, Wei H, Li P, Zhou Y, Zeng Q, Xu C, Zhang X.Fascial space priority approach for laparoscopic total pelvicexenteration in patients with locally advanced rectal cancer. SurgEndosc. 2022 Aug;36(8):6331-6335

[6] ChenS, Wang Y, Wang K, Zhang L, Zhang X. Circulating tumor DNA-basedearly detection of precancerous colorectal lesions using QClampXNA-mediated real-time PCR. Pharmazie. 2021;76(12):606-10.

[7] LiuJ, Gu L, Zhang M, Zhang S, Wang M, Long Y, Zhang X. The FecalMicrobiota Transplantation: A Remarkable Clinical Therapy for SlowTransit Constipation in Future. Front Cell Infect Microbiol. 2021 Oct22;11:732474.

[8] SunY, Yang H, Zhang Z, Zhou Y, Li P, Zeng Q, Zhang X. A novel surgicalapproach in dealing with the confusing sites in total mesorectalexcision: fascial space priority approach with two tunnelsestablished. Tech Coloproctol. 2021 Sep 13.

[9] ChenS, Wang Y, Xu M, Zhang L, Su Y, Wang B, Zhang X. miR-1184 regulatesthe proliferation and apoptosis of colon cancer cells via targetingCSNK2A1. Mol Cell Probes. 2020 Oct;53:101625.

[10] SunY, Lian L, Zhang H, Bai X, Xie Z, Ouyang J, Wang K, Yuan H, Xu C, LuoH, Deng H, Li J, Yang H, Zhang Z, Li P, Zhang X. The feasibility andtechnical strategy of a fascia space priority approach inlaparoscopic lateral lymph node dissection for advanced middle andlow rectal cancer: a retrospective multicentre study. Wideochir InneTech Maloinwazyjne. 2021 Jun;16(2):312-320.

[11] XuM, Yuan L, Wang Y, Chen S, Zhang L, Zhang X. Integrative Analysis ofDNA Methylation and Gene Expression Profiles Identifies ColorectalCancer-Related Diagnostic Biomarkers. Pathol Oncol Res. 2021 Jul21;27:1609784.

[12] JiL, Chen S, Gu L, Zhang X. Exploration of Potential Roles of m6ARegulators in Colorectal Cancer Prognosis. Front Oncol. 2020 May15;10:768.

[13] LiS, Chen S, Wang B, Zhang L, Su Y, Zhang X. The long noncoding RNALINC00341 suppresses colorectal carcinoma by preventing cellmigration and apoptosis. Cell Biochem Funct. 2020 Apr;38(3):266-274.

[14] LiS, Chen S, Wang B, Zhang L, Su Y, Zhang X. A Robust 6-lncRNAPrognostic Signature for Predicting the Prognosis of Patients WithColorectal Cancer Metastasis. Front Med (Lausanne). 2020 Mar 6;7:56.

[15] JiL, Chen S, Gu L, Wang J, Zhang X. LncRNA AGAP2-AS1 Promotes CancerCell Proliferation, Migration and Invasion in Colon Cancer by Forminga Negative Feedback Loop with LINC-PINT. Cancer Manag Res. 2021 Mar2;13:2153-2161.

[16] ZhangZ, Wang D, Xu C, Li Y, Yu Y, Chen C, Li M, Zhang X. Analysis ofexpression levels of markers associated with tumor proliferation andangiogenesis in familial adenomatous polyposis. Mol Genet GenomicMed. 2020 Dec;8(12):e1534.

[17] SuY, Zhang M, Zhang L, Chen S, Zhang D, Zhang X. Construction of anmiRNA-mRNA regulatory network in colorectal cancer withbioinformatics methods. Anticancer Drugs. 2019 Jul;30(6):588-595.

[18] ZhangL, Chen S, Wang B, Su Y, Li S, Liu G, Zhang X. An eight-longnoncoding RNA expression signature for colorectal cancer patients'prognosis. J Cell Biochem. 2019 Apr;120(4):5636-5643.

[19] ChenS, Zhang L, Su Y, Zhang X. Screening potential biomarkers forcolorectal cancer based on circular RNA chips. Oncol Rep. 2018Jun;39(6):2499-2512.

[20] GuL, Yu J, Wang Q, Xu B, Ji L, Yu L, Zhang X, Cai H. Identification ofa 5 lncRNA signature based risk scoring system for survivalprediction in colorectal cancer. Mol Med Rep. 2018 Jul;18(1):279-291.

[21] ChenS, Wang Y, Su Y, Zhang L, Zhang M, Li X, Wang J, Zhang X. miR 2055p/PTK7 axis is involved in the proliferation, migration and invasionof colorectal cancer cells. Mol Med Rep. 2018 May;17(5):6253-6260.

[22] WangT, Xu H, Liu X, Chen S, Zhou Y, Zhang X. Identification of Key Genesin Colorectal Cancer Regulated by miR-34a. Med Sci Monit. 2017 Dec3;23:5735-5743.

[23] ChenS, Wang Y, Zhang L, Su Y, Zhang M, Wang J, Zhang X. Exploration ofthe mechanism of colorectal cancer metastasis using microarrayanalysis. Oncol Lett. 2017 Dec;14(6):6671-6677.

[24] ZhangC, Li X, Fu W, Wang Y, Wang T, Wang W, Chen S, Qin H, Zhang X. SMAD7rs4939827 variant contributes to colorectal cancer risk in Chinesepopulation. Oncotarget. 2017 Jun 20;8(25):41125-41131.

[25] ZhangC, Li X, Zhang W, Wang Y, Fan G, Wang W, Chen S, Qin H, Zhang X.Common genetic variant rs3802842 in 11q23 contributes to colorectalcancer risk in Chinese population. Oncotarget. 2017 Jul31;8(42):72227-72234.

[26] HuaY, Ma X, Liu X, Yuan X, Qin H, Zhang X. Abnormal expression of mRNA,microRNA alteration and aberrant DNA methylation patterns in rectaladenocarcinoma. PLoS One. 2017 Mar 28;12(3):e0174461.

[27] ShiY, Yu Y, Zhang X, Li Y. Transvaginal Mesh and Transanal Resection toTreat Outlet Obstruction Constipation Caused by Rectocele. Med SciMonit. 2017 Feb 1;23:598-605.

[28] HuaY, Ma X, Liu X, Yuan X, Qin H, Zhang X. Identification of thepotential biomarkers for the metastasis of rectal adenocarcinoma.APMIS. 2017 Feb;125(2):93-100.

[29] LiS, Fang Y, Qin H, Fu W, Zhang X. miR-659-3p is involved in theregulation of the chemotherapy response of colorectal cancer viamodulating the expression of SPHK1. Am J Cancer Res. 2016 Sep1;6(9):1976-1985.

[30] XuC, Chen S, Wang T, Zhao K, You X, Wang Y, Zhang X, Li Y. Quantitativeassessment of the influence of glutathione S-transferase M1 nullvariant on ovarian cancer risk. J Cancer Res Ther. 2014 Nov;10Suppl:C201-5.

[31] LiuJ, Gu L, Zhang M, Zhang S, Wang M, Long Y, Zhang X. The FecalMicrobiota Transplantation: A Remarkable Clinical Therapy for SlowTransit Constipation in Future. Front Cell Infect Microbiol. 2021 Oct22;11:732474.

[32] LiP, Zhang Z, Zhou Y, Zeng Q, Zhang X, Sun Y. Metastasis to laterallymph nodes with no mesenteric lymph node involvement in low rectalcancer: a retrospective case series. World J Surg Oncol. 2020 Nov6;18(1):288.

[33] GaoWF, Li YX, Zhang WH, Tao R, Yin TT, Wang YJ, Liu LN, Fu ZW, Li SN,Liu NR, Zhang H, Liu G, Zhao LZ, Zhang XP, Zhang CZ. Comparison ofthe inhibition potential of parthenolide and micheliolide on variousUDP-glucuronosyltransferase isoforms. Xenobiotica. 2019Oct;49(10):1158-1163.

[34] ZhangC, Wang Y, Hu X, Qin L, Yin T, Fu W, Fan G, Zhang H, Liu G, Jiang Z,Zhang X, Li X. An Improved NGS Library Construction Approach UsingDNA Isolated from Human Cancer Formalin-Fixed Paraffin-EmbeddedSamples. Anat Rec (Hoboken). 2019 Jun;302(6):941-946.

[35] GuLQ, Xing XL, Cai H, Si AF, Hu XR, Ma QY, Zheng ML, Wang RY, Li HY,Zhang XP. Long non-coding RNA DILC suppresses cell proliferation andmetastasis in colorectal cancer. Gene. 2018 Aug 5;666:18-26.

[36] YuY, Li Y, Xu C, Zhang Z, Zhang X. Comparison of long course and shortcourse preoperative radiotherapy in the treatment of locally advancedrectal cancer: a systematic review and meta-analysis. Rev Esp EnfermDig. 2019 Jan;111(1):17-27.

[37] LiY, Yu Y, Li S, Zhang M, Zhang Z, Zhang X, Shi Y, Zhang S. Isobarictags for relative and absolute quantification-based proteomicanalysis that reveals the roles of progesterone receptor,inflammation, and fibrosis for slow-transit constipation. JGastroenterol Hepatol. 2018 Feb;33(2):385-392.

[38] ZhangZ, Liang S, Wang D, Liang S, Li Y, Wang B, Jiang T, Zhao G, Zhang X,Banerjee S. A novel pathogenic single nucleotide germline deletion inAPC gene in a four generation Chinese family with familialadenomatous polyposis. Sci Rep. 2017 Sep 27;7(1):12357.

[39] WangD, Liang S, Zhang Z, Zhao G, Hu Y, Liang S, Zhang X, Banerjee S. Anovel pathogenic splice acceptor site germline mutation in intron 14of the APC gene in a Chinese family with familial adenomatouspolyposis. Oncotarget. 2017 Mar 28;8(13):21327-21335.

6. 荣誉和奖励

天津市临床重点学科带头人，“张锡朋”劳模创新工作室负责人。曾获全国五一劳动奖章(2018)、天津市劳动模范(2015)、天津市十佳医务工作者(2012)，首届“天津名医”（2020）等荣誉称号，入选天津市131创新型人才团队。

奖励：

1.天津市科学技术进步奖二等奖，基于60000余例肛周疾病建立的规范化诊疗体系，2020，第1完成人

2.天津市科学技术进步奖二等奖，6000余例中低位直肠癌临床诊治及随访，2018，第1完成人

3.天津市科学技术进步奖三等奖，多倍体肿瘤巨细胞在肿瘤发生发展中的作用及其机制，2016，第2完成人

7. 联系方式

联系邮箱：zhxp1011@163.com

联系地址：天津市红桥区芥园道190号天津市人民医院肛肠病诊疗中心