本人照片

姓名：张春泽

职称：主任医师

导师类型：博士研究生导师/硕士研究生导师

1. 教育经历

2011/09-2014/06：天津中医药大学，中西医结合临床系，博士（导师：江涛）。

2008/09-2011/06：天津中医药大学，中西医结合临床系，硕士（导师：马东旺）；

2. 工作经历

2004/08--2006/10：天津市第一中心医院，普通外科，医师；

2006/11--2015/10：天津市人民医院，肛肠外科，主治医师；

2015/11--2017/07：天津市人民医院，肛肠外科，副主任医师；

2017/08--2018/08：美国H.LeeMoffitt癌症中心，博士后

2018/09--2021/01：天津市人民医院，肛肠外科，副主任医师；

2021/02——至今：天津市人民医院，肛肠外科，主任医师。

3. 研究方向（可以填写多个方向）

1. 表观调控消化系统肿瘤的作用机制与临床研究;

2. 中药及天然产物抗癌作用与机制研究。

4. 学术兼职

1. 中国老年学和老年医学学会肿瘤康复分会常务委员

2. 中国中西医结合科研院所工作委员会委员

3. 中国医师协会科普分会肛肠专委会委员

4. 天津市预防医学会毒理分会委员

5. 天津市医师协会肛肠专业委员会委员，科普与预防专委会主任

6. 天津市中西医结合学会循证医学专业委员会委员

7. 国际CSCO肿瘤学会会员

8. 《中国肿瘤生物治疗杂志》特邀审稿专家

9. 天津市抗衰老学会大肠肛门病专委会委员

10. 天津市药理学会网络药理学分会副主委

5. 代表性学术论文

第一作者论文

1. Jianmei Wei#, Chunze Zhang#, Yunhuan Gao，Yuanyuan Lia, Qianjing Zhang, Houbao Qi, Mengli Jin, Xiaorong Yang, Xiaomin Su, Yuan Zhang & Rongcun Yang. Gut Epithelial-derived CXCL9 Maintains Gut Homeostasis through Preventing Overgrown E. coli. Journal of Crohn's and Colitis. 影响因子: 9.1.

2. Yijia Wang, * Chunze Zhang, * Shaobin Hou, Xiaojing Wu1 Jun Liu4 Xuehua Wan5.Analyses of Potential Driver and Passenger Bacteria in Human Colorectal Cancer.Cancer Management and Research.2020.课题号:81972826, 63191440, 19YFZCSY00420,2017YFC1700604,2017YFC1700606,2018YJ023.

3. Chunze Zhang#, Tingting Yin#, Tao Ran#, Jing Chen, Bo Xiao, Xueyuan Miao, Xichuan Li *，Wei Zhang*，Elevated nuclear YBX1 expression and the clinicopathological characteristics of patients in solid tumors: a meta-analysis, Cancer management and research, 2019, 11: 4391-4402.影响因子：2.5.课题号:81872236, 18JCYBJC28100,2014KZ053, 2017058,2017057,2018094,2016YJ029.

4. Chunze Zhang＃, Yijia Wang＃, Xia Hu＃, Litao Qin＃, Tingting Yin, Wenzheng Fu, Guanwei Fan，Heng Zhang, Guang Liu, Zhi Jiang, Xipeng Zhang*, Xichuan Li*, An improved NGS library construction approach using DNA isolated from human cancer formalin-fixed paraffin-embedded samples. The Anatomical Record, 2018, 2018, 302 (6), 941-946.影响因子：1.373.课题号:2016YJZD006,81472681, 2017057.

5. Dan Sun#, Chun-Ze Zhang#, Rui-Xue Ran, Yun-Feng Cao, Zuo Du, Zhi-Wei Fu, Chun-Ting Huang, Zhen-Ying Zhao, Wei-Hua Zhang* and Zhong-Ze Fang*, In Vitro Comparative Study of the Inhibitory Effects of Mangiferin and Its Aglycone Norathyriol towards UDP-Glucuronosyl Transferase (UGT) Isoforms. Molecules, 2017, 22(6):1008，影响因子：2.465.课题号:2016YFC0903100, 2016YFC0903102, Grant No. 15JCY-BJC54700, 2016M590210, 2014KR14, 16KG154, No. LNCCC-B05-2015. 11601501, 2016KJ0313.

6. Chunze Zhang#, Xichuan Li#, Weihua Zhang, Yijia Wang, Guanwei Fan, Wenhong Wang, Shuo Chen, Hai Qin and Xipeng Zhang*, Common genetic variant rs3802842 in 11q23 contributes to colorectal cancer risk in Chinese population. Oncotarget, Advance Publications ,2017,8(42):72227-72234. .影响因子：5.008.课题号:2014KR14, 2016YJZD006, 4KG108, 2010KG206,16KG154.

7. Chunze Zhang#, Xiaoting Li1#, Dan Gao, Haihua Ruan, Zhenzhen Lin, Xiaobo Li, Guang Liu, Zhicheng Ma and Xichuan Li*, The prognostic value of over-expressed TrkB in solid tumors: a systematic review and meta-analysis. Oncotarget, 2017 , 8 (59) :99394.影响因子：5.008.课题号:81472681,31540066, 2014KR14.

8. Lingling Wang#, Chunze Zhang#, Litao Qin, Jingyue Xu, Xiaobo Li1, Wenhong Wang, Lingqin Kong, Taizhen Zhou and Xichuan Li*, The prognostic value of NRF2 in solid tumor patients: a meta-analysis. Oncotarget, Advance Publications 2017 9(1):1257-1265.影响因子：5.008.课题号:81472681,2014KR14.

9. Chunze Zhang#, Xichuan Li#, Wenzheng Fu, Yijia Wang, Tao Wang, Wenhong Wang, Shuo Chen, Hai Qin, Xipeng Zhang*, SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population. Oncotarget, Advance Publications, 2017, 11(5): 135-38.影响因子：5.008.课题号:2014KR14, 2016YJZD006，14KG108.

10. Yijia Wang#, Chunze Zhang#, Shiwu Zhang, Zhenying Zhao, Jiawen Wang, Jiali Song, YueWang, Jun Liu，Shaobin Hou*. Kanglaite sensitizes colorectal cancer cells to Taxol via NF-κΒinhibition and connexin 43 upregulation. Scientific Reports, 2017, 7(1):1280，影响因子：5.228.课题号:15JCQNJC42200, 2016YFC0102404, 81472729, 81672426, 81503127, 2014KR14, 2016YJ033.

11. Huan-Huan Wang#, Chun-Ze Zhang#, Bai-Lin Zhang, Jie Chen, Xian-Liang Zeng, Lei Deng, Mao-Bin Meng*. Sublobar resection is associated with improved outcomes over radiotherapy in the management of high-risk elderly patients with Stage I non-small cell lung cancer: a systematic review and meta-analysis[J]. Oncotarget ,2016,8(4):6033-6042，影响因子：5.008.课题号:2014KR14

12. Ruixue Ran#, Chunze Zhang#, Rongshan Li , Bowei Chen , Weihua Zhang , Zhenying Zhao ,Zhiwei Fu , Zuo Du , Xiaolang Du , Xiaolong Yang and Zhongze Fang* . Evaluation and Comparison of the Inhibition Effect of Astragaloside IV and Aglycone Cycloastragenol on Various UDP-Glucuronosyltransferase (UGT) Isoforms[J]. Molecules, 2016, 21(12):1616，影响因子：2.465. 课题号: 2016YFC0903102,Grant No.15JCYBJC54700,2016M590210, No.LNCCC-B05-2015.

13. Chunze Zhang#*, Yijia Wang#, Wenzheng Fu, Weihua Zhang, Tao Wang,Hai Qin. A Meta-analysis on the Effect of Ulinastatin on Serum Levels of C-Reactive Protein, Interleukin 6, and Tumor Necrosis Factor Alpha in Asian Patients with Acute Pancreatitis, Genetic testing and molecular biomarkers, 2016, 20(3): 1-7，影响因子：1.297.课题号:2014KR14.

14. Chunze Zhang, Chunjie Li, WenKang Zong, Meilin Xu*, Guanwei Fan, One case of inflammatory myofibroblastic tumor--a case report, Journal of cancer research and therapeutics, 2015,11(5): 131-33.影响因子：0.777.

15. Yongsheng Jia#, Chunze Zhang#, Liyan Zhou#, Huijun Xu, Yehui Shi, Zhongsheng Tong*, Micheliolide overcomes KLF4-mediated cisplatin resistance in breast cancer cells by downregulating glutathione, OncoTargets and therapy, 2015,8: 2319-27.影响因子：2.272.课题号：2015BAI12B15, 81302080, 12ZCDZSY16200, 20131202120003, 14JCQNJC11100, 2013KYQ06.

16. Tao Wang#, Huilan Nan#, Chunze Zhang#, Yan Wang, Xipeng Zhang, Yuwei Li, Mulati*, Aidi injection combined with FOLFOX4 chemotherapy regimen in the treatment of advanced colorectal carcinoma, Journal of cancer research and therapeutics, 2014,10(S1): 52-5.影响因子：1.359.

通讯作者论文

1. Wang J, Qiao Y, Sun M,Sun H, Xie F, Chang H, Wang Y, Song J, Lai S,Yang C, Li X, Liu S, Zhao X, Ni K, Meng K, Zhang S, Shan C*, Zhang C*. FTO promotes colorectal cancer progression and chemotherapy response via demethylating G6PD/PARP1. Clin Transl Med. 2022. (影响因子:11.492)

2. Bao X, Liu Y, Huang J, Yin S, Sheng H, Han X, Chen Q, Wang T, Chen S, Qiu Y, Zhang C*, Yu H*. Stachydrine hydrochloride inhibits hepatocellular carcinoma progression via LIF/AMPK axis. Phytomedicine. 2022 Jun;100:154066. doi: 10.1016/j.phymed.2022.154066. Epub 2022 Mar 21. PMID: 35366490. (影响因子:5.340)

3. Gao W#, Yuan Z#, Zhao X#, Wang S#, Lai S, Ni K, Zhan Y, Liu Z, Liu L, Xin R, Yin X, Zhou X, Liu X, Zhang X, Zhang Q, Li G, Wang W*, Zhang C*. The prognostic and clinical value of p53 upregulated modulator of apoptosis expression in solid tumours: a meta-analysis and TCGA data review. Expert Review of Molecular Diagnostics. 2022 Sep. (影响因子:5.670)

4. Yuan Z#, Wang S#, Ni K#, Zhan Y#, Ma H, Liu X, Xin R, Zhou X, Liu Z, Zhao X, Yin X, Ping H, Liu Y, Wang W, Yan S, Han Q, Cui W, Zhang X, Zhang Q*, Zhang C*. Circulating Methylated SEPT9 DNA Analyses to Predict Recurrence Risk and Adjuvant Chemotherapy Benefit in Stage II to III Colorectal Cancer. Med Sci Monit 2022; 28:e938365. doi: 10.12659/MSM.938365 (影响因子:3.386)

5. Xichuan Li #, Ce Wang#, Jinqian Chen#, Xia Hu#, Hao Zhang, Zhiying Li, Bei Lan, Yan-Jun Su, Chunze Zhang*，Potential interactions among myricetin and dietary flavonols through the inhibition of human UDP-glucuronosyltransferase in vitro, Toxicology Letters. 影响因子：4.4. 课题号: 19YFZCSY00420

6. Wu X, Wang S, Zhao X, Lai S, Yuan Z, Zhan Y, Ni K, Liu Z, Liu L, Xin R, Zhou X, Yin X, Liu X, Zhang X, Cui W, Zhang C*. Clinicopathological and prognostic value of SIRT6 in patients with solid tumors: a meta-analysis and TCGA data review. Cancer Cell Int. 2022 Feb 16;22(1):84. doi: 10.1186/s12935-022-02511-3. PMID: 35172823; PMCID: PMC8848894. 影响因子：5.7 课题号: 19YFZCSY00420

7. Kemin Ni#, Yixiang Zhan#, Zhaoce Liu#, Xuan-zhu Zhao, Wanting Wang, Guihua Wang, Zili Zhang, Guo Xunli, Xipeng Zhang, Chunze Zhang*, Mismatch Repair System Deficiency Is Associated with Chemoradiotherapy Resistance in Locally Advanced Rectal Adenocarcinoma Patients, Journal of Surgical Oncology. 影响因子：3.5. 课题号: 19YFZCSY00420

8. Wang G, Bi Y, Xiong H, Bo T, Han L, Zhou L, Zhang C*, Zhang Y*. Wedelolactone protects against cisplatin-induced nephrotoxicity in mice via inhibition of organic cation transporter 2. Hum Exp Toxicol. 2021 Dec;40(12_suppl):S447-S459. 影响因子：2.9. 课题号: 19YFZCSY00420

9. Kai Zhen#, Jie Zhang#, Qinghuai Zhang,Ningning Chai, Lina Liu, Xichuan Li，Chunze Zhang*，A novel NGS-based microsatellite instability (MSI) status classifier with 9 loci for colorectal cancer patients，Journal of Translational Medicine. 2020，18（1）：215.影响因子：4.1.课题号:2017057, 2018094, 19YFZCSY00420,18JCYBJC28100,81872236,1707.

10. Yixuan Li#, Weihua Zhang#,Tingting Yin, Ce Wang, Feige Wang, Jing Sun, Lina Liu, Qinghuai Zhang ,Chunze Zhang*，Inhibition of UDP-glucuronosyltransferases by different furoquinoline alkaloids，Xenobiotica.2020，50（10）：1170-1179.影响因子：1.8.课题号:2016YJZD006, 19YFZCSY00420, 2017057, 16KG154, 2014kZ053, 2018094.

11. X.C Li＃, J.J Zeng＃, T.T Yin＃, W.H Wang*, C.Z Zhang*,Baicalin Inhibiting GSDME-mediated Pyroptosis in Chemotherapy of Colorectal Cancer, Basic and Clinical Pharmacology and Toxicology, 2018, 123(6):36-36 Meeting Abstract 影响因子：2.7.

12. Weifeng Gao＃,Yixuan Li＃, Weihua Zhang#, Ran Tao, Ting-Ting Yin, Yi-Jia Wang, Li-Na Liu, Zhi-Wei Fu, Sai-Nan Li, Nai-Rong Liu, Heng Zhang, Guang Liu, Li-Zhong Zhao, Xi-Peng Zhang, Chunze Zhang*, Comparison of the inhibition potentialof parthenolide (PTL) and micheliolide (MCL) on various UDP-Glucuronosyltransferase (UGT) isoforms, Xenobiotica,2018, 49:10, 1158-1163. 影响因子：1.8.课题号:2016YFC0903100, 2016YFC0903102, 11601501,2016KJ0313, 81602850, 2016M590210, 2017T100164, 16KG154, KF2017, YJSCX201816.

13. Jifang Cui#, Yandi Liu, Heng Zhang, Yijia Wang, Guang Liu, Weihua Zhang, Chunze Zhang*, Low BIN3 expression is an independent predictor of unfavorable survival in patients with primary colorectal cancer, Technology in cancer research and treatment. 2017, 16 (6) :1244-1251.影响因子：2.2.课题号:无

6. 荣誉和奖励

2020年被评为《中国肿瘤生物治疗杂志》2018-2019年度优秀审稿专家

2018年取得美国H.LEEMOFFITT癌症中心博士后，

2018年被天津市人民医院评为优秀临床指导教师，

2018年第八届天津国际结直肠外科高峰论坛-结直肠腹腔镜手术视频大赛中荣获第二名。

2017年荣获天津市“131”创新型人才培养工程第一层次

2015年被大中华结直肠腔镜外科学院评为“实力达人”，

2012年荣获中国医师协会外科医师分会“优秀奖”。

7. 联系方式

联系邮箱：chunze.zhang@nankai.edu.cn

联系地址：天津市红桥区芥园道190号