姓名：沈文

职称：主任医师

导师类型：博士研究生导师

1. 教育经历

1984年9月~1989年7月 天津第二医学院 医学影像学 学士学位

1999年9月~2002年7月 天津医科大学 影像医学与核医学  硕士学位

2003年9月~2006年7月 天津医科大学 影像医学与核医学  博士学位

2. 工作经历

1989年8月~1995年8月  天津市第一中心医院 放射科   住院医师
1995年8月~2000年8月  天津市第一中心医院 放射科   主治医师
2000年8月~2004年8月  天津市第一中心医院 放射科   副主任医师
2004年8月~至今        天津市第一中心医院  放射科  主任医师

3. 研究方向（可以填写多个方向）

腹盆部功能影像学研究与应用、器官移植相关功能影像学评估、磁共振新技术应用研究、盆底三维有限元分析及肾血管流体力学研究

1.     基于多参数MRI探索慢性肝病肾损伤演进机制和风险预估的研究，国家自然科学基金面上项目，2023/01-2026/12

2.     基于图神经网络模型的肝性脑病发生、进展及干预效果的预测研究，天津市卫生健康委员会重点学科专项，2023/07 - 2026/06

3.     慢性肝病肾损伤及干细胞干预的MRI定量研究，天津市科学技术基金面上项目，2021/10-2024/09

4.     多模态fMRI评价肾脏冷缺血再灌注损伤微观特点的研究，国家自然科学基金面上项目，2019/01-2022/12

5.     肝纤维化多参数MRI与病理形态学改变的定量对比研究，国家自然科学基金面上项目，2017/01-2018/12

6.     MRI评价肝部分切除后残肝微观变化及其与再生结局关系的实验研究，国家自然科学基金青年项目，2020/01-2022/12

7.     脂肪肝部分切除后再生过程及结局预估的多参数MRI研究，天津市科学技术基金青年项目，2021/10-2023/09

8.     静动态MRI探究经阴道分娩初产妇产后盆底功能障碍性疾病发生、发展机制，天津市科学技术青年项目，2021/10-2023/09

9.     影像组学预测子宫内膜癌患者淋巴结转移及预后生存的临床应用研究，天津市卫健委面上项目，2020/08-2023/08

10.  基于多模态MRI影像组学探索肝纤维化早期诊断的价值研究，天津市卫健委青年项目，2022/08-2025/07

11.  增强MRI相关组学模型预测HCC微血管侵犯及早期复发研究，天津市卫健委青年项目，2021/12-2024/11 

12.  多期CT全肿瘤影像组学特征与HCC预后相关病理指标的关系及对手术切除后早期复发的预测价值，天津市卫健委青年项目，2020/08-2023/07

4. 学术兼职

  中华医学会放射学分会第十三~十五届全国委员及第十五届MR学组副组长，中华医学会放射学分会腹部学组第十三届~十四届委员、十六届MRI学组及科普学组委员、中国医师协会放射医师分会全国委员、中国医师协会放射医师分会消化学组委员及泌尿学组副组长、中国医学影像技术研究会常务理事、中国研究型医院学会肿瘤影像诊断学专委会常委、中国研究型医院学会磁共振专业委员会常委、中国装备学会CT及MR专业委员会常委、中国医学装备协会中国医学影像发展联盟第一届理事会常务理事、中国医疗保健国际交流促进会放射分会常务委员，中国医师协会整合医学医师分会整合影像专业委员会常务委员，中国女医师协会医学影像专家委员会委员，中国医师协会外科医师分会MDT专委会委员，中国乳腺癌风险防控及早治联盟委员，中国医学装备人工智能联盟影像委员会委员，海峡两岸医药卫生交流协会放射学专业委员会常务委员，天津市抗癌协会影像专委会主委、天津市放射学会副主委、天津市毕业后教育医技质控组组长、天津市医师协会放射医师分会常委，天津市医学影像技术研究会放射分会常务委员，天津市医学影像质控中心副主任委员，天津市门静脉高压联盟副理事长，中华放射学杂志编委、国际医学放射学杂志副主编、临床放射学杂志编委、实用放射学杂志副主编编委、磁共振成像杂志编委、放射学实践杂志编委、中国医学影像技术杂志编委、天津医药杂志、影像诊断与介入放射学杂志编委。

5. 代表性学术论文

1. Zhang K, He K, Zhang L, Li WC, Xie SS, Cui YZ, Lin LY, Shen ZW, Xia S, Su XM, Zhang HM, Ye ZX^*, Shen W^*. Gadoxetic Acid-enhanced MRI Scoring Model to Predict Pathologic Features of Hepatocellular Carcinoma. Radiology. 2025 Feb;314(2):e233229.

2. Xie S, Chen M, Chen C, Zhao Y, Qin J, Qiu C, Zhu J, Nickel MD, Kuehn B, Shen W^*. T1 mapping combined with arterial spin labeling MRI to identify renal injury in patients with liver cirrhosis. Front Endocrinol (Lausanne). 2024 Aug 9;15:1363797.

3. Chen L, Ren Y, Yuan Y, Xu J, Wen B, Xie S, Zhu J, Li W, Gong X, Shen W^*. Multi-parametric MRI-based machine learning model for prediction of pathological grade of renal injury in a rat kidney cold ischemia-reperfusion injury model. BMC Med Imaging. 2024 Jul 26;24(1):188.

4. Qin J, Xie S^*, Yu Y, Yang J, Zhao Y, Qiu C, Li X, Zhang C, Hu Z, Tong D, Zhu J, Kuehn B, Shen W^*. Evaluation of Kidney Injury Using Arterial Spin Labeling and Blood Oxygen Level-Dependent MRI: An Experimental Study in Rats With Carbon Tetrachloride-Induced Liver Cirrhosis. J Magn Reson Imaging. 2024 Feb 1.

5. Zhang C, Ma L, Zhao Y, Zhang Z, Zhang Q, Li X, Qin J, Ren Y, Hu Z, Zhao Q, Shen W^*, Cheng Y^*. Estimating pathological prognostic factors in epithelial ovarian cancers using apparent diffusion coefficients of functional tumor volume. Eur J Radiol. 2024 Jul;176:111514.

6. Wang X, Xie S^*, Qiu C, Du X, Qin J, Hu Z, Grimm R, Zhu J, Shen W^*. Use of Intravoxel Incoherent Motion Diffusion-Weighted Imaging to Assess Mesenchymal Stromal Cells Promoting Liver Regeneration in a Rat Model. Acad Radiol. 2024 Jun 21:S1076-6332(24)00302-7.

7. Cui Q, Yu J, Ge X, Gao G, Liu Y, He Q, Shen W^*. Diagnostic value of LGE and T1 mapping in multiple myeloma patients'heart. BMC Cardiovasc Disord. 2024 Apr 27;24(1):230.

8. Du G^#, Chen L^#, Wen B, Lu Y, Xia F, Liu Q, Shen W^*. Deep learning-based prediction of tumor aggressiveness in RCC using multiparametric MRI: a pilot study. Int Urol Nephrol. 2024 Dec 13.

9. Liu L^#, Ji X^#, Liang C, Zhu J, Huang L, Zhao Y, Xu X, Song Z, Shen W^*. An MRI-based radiomics nomogram to predict progression-free survival in patients with endometrial cancer. Future Oncol. 2024 Sep 17:1-15.

10. Zhao Y, You C, Zhou X, Li X, Zhang C, Wu Y, Shen W^*. The volumetric ADC histogram analysis in differentiating stage IA endometrial carcinoma from endometrial polyp. Br J Radiol. 2024 May 29;97(1158):1139-1145.

11. Ren Y, Chen L, Yuan Y, Xu J, Xia F, Zhu J, Shen W^*. Evaluation of renal cold ischemia-reperfusion injury with intravoxel incoherent motion diffusion-weighted imaging and blood oxygenation level-dependent MRI in a rat model. Front Physiol. 2023 May 22;14:1159741.

12. You C^#, Zhao Y^#, Zhang C, Chen M, Shen W^*. Pelvic floor parameters predict postpartum stress urinary incontinence: a prospective MRI study. Insights Imaging. 2023 Sep 27;14(1):160.

13. Zhao YM, Xie SS, Wang J, Zhang YM, Li WC, Ye ZX, Shen W^*. Added value of CE-CT radiomics to predict high Ki-67 expression in hepatocellular carcinoma. BMC Med Imaging. 2023 Sep 22;23(1):138.

14. Zhao Y, Zhang C, Cui C, Zhang X, Zhao Q, Shen W^*. Longitudinal changes in pelvic organ support among primiparas with postpartum pelvic organ prolapse: A follow-up magnetic resonance imaging study. Int J Gynaecol Obstet. 2023 Aug;162(2):514-524.

15. Zhang K, Zhang L, Li WC, Xie SS, Cui YZ, Lin LY, Shen ZW, Zhang HM, Xia S, Ye ZX^*, He K^*, Shen W^*. Radiomics nomogram for the prediction of microvascular invasion of HCC and patients' benefit from postoperative adjuvant TACE: a multi-center study. Eur Radiol. 2023 Dec;33(12):8936-8947.

16. Liu X, Lin P, Shen W^*, Yang Y^*. A population-based model identifying optimal candidate for primary tumor resection in distant metastatic laryngeal carcinoma. Eur Arch Otorhinolaryngol. 2023 Jun;280(6):2885-2896.

17. Wang H, Yang Q, Li F, Wang H, Yu J, Ge X, Gao G, Xia S, Xing Z^*, Shen W^*. The Risk Factors and Outcomes for Radiological Abnormalities in Early Convalescence of COVID-19 Patients Caused by the SARS-CoV-2 Omicron Variant: A Retrospective, Multicenter Follow-up Study. J Korean Med Sci. 2023 Feb 27;38(8):e55.

18. Xue K, Gao B, Chen F, Wang M, Cheng J, Zhang B, Zhu W, Qiu S, Geng Z, Zhang X, Cui G, Yu Y, Zhang Q, Liao W, Zhang H, Xu X, Han T, Qin W, Liu F, Liang M, Guo L, Xu Q, Xu J, Fu J, Zhang P, Li W, Shi D, Wang C, Lui S, Yan Z, Zhang J, Li J, Wang D, Xian J, Xu K, Zuo XN, Zhang L, Ye Z, Banaschewski T, Barker GJ, Bokde ALW, Desrivières S, Flor H, Grigis A, Garavan H, Gowland P, Heinz A, Brühl R, Martinot JL, Martinot MP, Artiges E, Nees F, Orfanos DP, Lemaitre H, Poustka L, Hohmann S, Holz N, Fröhner JH, Smolka MN, Vaidya N, Walter H, Whelan R, Shen W^*, Miao Y^*, Yu C^*. Covariation of preadult environmental exposures, adult brain imaging phenotypes, and adult personality traits. Mol Psychiatry. 2023 Nov;28(11):4853-4866.

19. Yan Z, Chen L, Shen W^*, Dong L, Wang C, Guan Y, Zheng M, Li Y, Zhang C, Grimm R. Preliminary study on intravoxel incoherent motion imaging and diffusion kurtosis imaging based on magnetic resonance imaging of normal kidneys in children. Transl Pediatr. 2022 Dec;11(12):1928-1938.

20. Wang D^#, Yue J^#, Cao Q^#, Liu J, Yang L^*, Shen W^*, Zhang W^*, Liu J^*. ICG-loaded and 125I-labeled theranostic nanosystem for multimodality imaging-navigated phototherapy of breast cancer. Biomater Sci. 2022 Dec 20;11(1):248-262.

21. Xie S, Qiu C, Sun Y, Yu Y, Zhang Q, Bao M, Zhu J, Grimm R, Shen W^*. Series of Intravoxel Incoherent Motion and T2* Magnetic Resonance Imaging Mapping in Detection of Liver Perfusion Changes and Regeneration Among Partial Hepatectomy in Sprague-Dawley Rats. Acad Radiol. 2022 Dec;29(12):1810-1818.

22. Zhang K, Xie SS, Li WC, Ye ZX, Shen ZW, Shen W^*. Prediction of microvascular invasion in HCC by a scoring model combining Gd-EOB-DTPA MRI and biochemical indicators. Eur Radiol. 2022 Jun;32(6):4186-4197.

23. Zhang K, Shi X, Xie SS, Sun JH, Liu ZH, Zhang S, Song JY, Shen W^*. Deep learning image reconstruction in pediatric abdominal and chest computed tomography: a comparison of image quality and radiation dose. Quant Imaging Med Surg. 2022 Jun;12(6):3238-3250.

24. Xie S, Qiu C, Sun Y, Yu Y, Hu Z, Zhang K, Chen L, Cheng Y, Bao M, Zhang Q, Zhu J, Grimm R, Shen W^*. Assessment of Fibrotic Liver Regeneration After Partial Hepatectomy With Intravoxel Incoherent Motion Diffusion-Weighted Imaging: An Experimental Study in a Rat Model With Carbon Tetrachloride Induced Liver Injury. Front Physiol. 2022 Feb 18;13:822763.

25. Liu X, Sun C, Long M, Yang Y, Lin P, Xia S, Shen W^*. Computed tomography-based radiomics signature as a pretreatment predictor of progression-free survival in locally advanced hypopharyngeal carcinoma with a different response to induction chemotherapy. Eur Arch Otorhinolaryngol. 2022 Jul;279(7):3551-3562.

26. Qiu C, Xie S, Shen W^*. Editorial for Characterizing Fibrosis and Inflammation in a Partial Bile Duct Ligation Mouse Model by Multiparametric Magnetic Resonance Imaging. J Magn Reson Imaging. 2022 Jun;55(6):1875-1876.

27. Qiu C, Xie S, Sun Y, Yu Y, Zhang K, Wang X, Zhu J, Grimm R, Shen W^*. Multi-parametric magnetic resonance imaging of liver regeneration in a standardized partial hepatectomy rat model. BMC Gastroenterol. 2022 Oct 9;22(1):430.

28. Zhang K, Li WC, Xie SS, Lin LY, Shen ZW, Ye ZX^*, Shen W^*. Preoperative determination of pathological grades of primary single HCC: development and validation of a scoring model. Abdom Radiol (NY). 2022 Oct;47(10):3468-3477.

29. Liu X, Long M, Sun C, Yang Y, Lin P, Shen Z, Xia S^*, Shen W^*. CT-based radiomics signature analysis for evaluation of response to induction chemotherapy and progression-free survival in locally advanced hypopharyngeal carcinoma. Eur Radiol. 2022 Nov;32(11):7755-7766.

30. Yu Y, Xie S, Wang K, Zhang F, Jiang C, Qiu C, Zhu J, Shen W^*. Perfusion Analysis of Kidney Injury in Rats With Cirrhosis Induced by Common Bile Duct Ligation Using Arterial Spin Labeling MRI. J Magn Reson Imaging. 2022 May;55(5):1393-1404.

31. Ji X^#, Huang W^#, Dong H, Shen Z, Zheng M, Zou D, Shen W^*, Xia S^*. Evaluation of bone marrow infiltration in multiple myeloma using whole-body diffusion-weighted imaging and T1-weighted water-fat separation Dixon. Quant Imaging Med Surg. 2021 Feb;11(2):641-651.

32. Liu Y, Yu J, Liu J, Wu B, Cui Q, Shen W^*, Xia S^*. Prognostic value of late gadolinium enhancement in arrhythmogenic right ventricular cardiomyopathy: a meta-analysis. Clin Radiol. 2021 Aug;76(8):628.e9-628.e15.

33. Chai C, Zhang M, Wang H, Li J, Zhang T, Han Y, Zhu J, Zhang X, Xia S^*, Shen W^*. Increased cerebral blood flow is correlated with neurocognitive impairment in long-term hemodialysis patients: an arterial spin labeling MRI study. Brain Imaging Behav. 2021 Aug;15(4):1828-1839.

34. Zhang G, Li Y, Zhang X, Huang L, Cheng Y^*, Shen W^*. Identifying Mild Hepatic Encephalopathy Based on Multi-Layer Modular Algorithm and Machine Learning. Front Neurosci. 2021 Jan 11;14:627062.

35. Xie S, Li Q, Cheng Y, Zhou L, Xia S, Li J, Shen W^*. Differentiating mild and substantial hepatic fibrosis from healthy controls: a comparison of diffusion kurtosis imaging and conventional diffusion-weighted imaging. Acta Radiol. 2020 Aug;61(8):1012-1020.

36. Xie S, Qi H, Li Q, Zhang K, Zhang L, Cheng Y, Shen W^*. Liver injury monitoring, fibrosis staging and inflammation grading using T1rho magnetic resonance imaging: an experimental study in rats with carbon tetrachloride intoxication. BMC Gastroenterol. 2020 Jan 15;20(1):14.

6. 荣誉和奖励

2020年入选天津首届名医

2014年度国家级科学技术进步奖一等奖，排名第五

2020天津市科技进步奖二等奖，排名第二

7. 联系方式

联系邮箱：shenwen66happy@163.com

联系地址：天津市南开区复康路24号