侯文，副研究员

一、学习经历

(1) 2005/02-2011/12，新加坡南洋理工大学，生物科学学院，博士

(2) 1999/09-2003/06，浙江大学，生命科学学院生物技术系，学士

二、工作经历

(1) 2022/12-至今，南开大学移植医学研究院，南开大学附属第一中心医院，副研究员

(2) 2016/08-2022/11，南开大学附属第一中心医院，助理研究员

(2) 2013/07-2016/07，天津大学生命科学学院，博士后

三、研究方向和课题

研究方向：缺血再灌注损伤、机械灌注、移植免疫排斥与耐受

主要课题：

1. 天津市自然科学基金重点项目，23JCZDJC01070，内源代谢物EETs调控肝移植免疫稳态的功能与机制研究，2023/10-2026/09,20万，主持，在研

2. 天津市自然科学基金重点项目,18JCZDJC34500，基于蛋白质组学的SFTS布尼亚病毒逃逸宿主天然免疫的机制研究，2018/04-2021/03,20万，主持，已结题

3. 国家自然科学基金面上项目，22371147，两性离子修饰两亲杯芳烃的设计合成及其药物递送研究，2024/01-2027/12，50万，在研，参与

4. 国家自然科学基金面上项目，32371265，STING/ALG-2复合物的结构及其在STING激活诱导的T细胞凋亡中的功能，2024/01-2027/12，50万，在研，参与

5. 国家自然科学基金面上项目，82072212，下丘脑室旁核STAT3/ET-1炎症反应通路在脑死亡进程中的作用及机制研究，2021/01-2024/12,55万，在研，参与

6. 国家自然科学基金面上项目，82072219，外泌体microRNA-122介导肝缺血再灌注致发育期海马损伤的机制研究，2021/01-2024/12，55万，在研，参与

7. 天津市自然科学基金面上项目，20JCYBJC00980，低温机械灌注减轻小肠缺血再灌注损伤的研究，2020/04-2024/03,20万元，在研，参与

8. 天津市自然科学基金青年项目，17JCQNJC12800，靶向沉默GARP表达的间充质干细胞对大鼠脂肪肝缺血再灌注损伤的保护作用及机制研究，2017/04-2020/03，6万元，已结题，参与

9. 天津市自然科学基金面上项目，17JCYBJC28000，小檗碱对脂肪供肝缺血再灌注损伤中自噬-凋亡平衡调控的机制研究，2017/04-2020/03，10万，已结题，参与

四、近五年主要发表论文

Z Wang, L Deng, Wen Hou, S Liu, Y Zhang, C Sheng, Y Zhang, J Li, Z Shen^*. Cancer mortality among solid organ transplant recipients: A systematic review and meta-analysis. Prev Med. 2024 Nov 2;189:108161.

Kong D, Wang Z, Wang H, Yang R, Zhang W, Cao L, Nian Y, Ren J, Lu J, Chen T, Duan J, Song Z, Liu T, Wen Hou, Yoshida S, Shen Z^*, Bromberg JS, Zheng H. Capecitabine mitigates cardiac allograft rejection via inhibition of TYMS-Mediated Th1 differentiation in mice. Int Immunopharmacol. 2024 Aug 19;141:112955.

Wen Hou, Jiansen Lu, Zirong Liu, Xuequan Feng, Hongsheng Liu^*. The protective effect of Dogwood preparation on hepatic ischemia-reperfusion injury in mice by down-regulating PTGS2. Arabian Journal of Chemistry, 2024, 17(2), February 2024, 105513.

Shuang Yang, Wen Hou^*, Lei Liu^*. Progress in preservation of intestinal grafts by oxygenated hypothermic machine perfusion. Transplantation Reviews, 2024 Jan; 38(1):100802.

Zhang M, Guan Y, Han M, Kong F, Xu A, Jin X, Hu X, Dong F, Zhang N, Peng X, Liu D, Chen Y, Zhao R, Zhu X, Zhang Y, Lu C, Hou W, Liu L, Li D^*, Zhang Z^*, Zhang X^*, Zhang S^*. Foxo1 Drives the TGFβ1-Dependent Dichotomy of Th17 Cell Fates. J Leukoc Biol. 2024 Jan 9:qiae004.

Jiansen Lu^#, Wen Hou^#, Shuang Yang, Decheng Chen, Fei Wang, Lei Liu^*, Zhongyang Shen^*. Trans-anethole pretreatment ameliorates hepatic ischemia-reperfusion injury via regulation of soluble epoxide hydrolase. International Immunopharmacology, 2023Sep 8; 124(Pt A): 110809.  

Wen Hou, Shuang Yang, Jiansen Lu, Yuan Shi, Jing Chen, Decheng Chen, Fei Wang, Lei Liu^*. Hypothermic machine perfusion alleviates ischemia-reperfusion injury of intestinal transplantation in pigs. Frontiers in Immunology, 2023, 14:1117292.

Sai Zhang, Shunli Fan, Zhenglu Wang, Wen Hou, Tao Liu, Sei Yoshida, Shuang Yang, Hong Zheng^* and Zhongyang Shen^*. Capecitabine Regulates HSP90AB1 Expression and Induces Apoptosis via Akt/SMARCC1/AP-1/ROS Axis in T Cells. Oxidative Medicine and Cellular Longevity, 2022 Mar 24; 2022:1012509 .

Wen Hou, Bao Wei, Hongsheng Liu^*. The protective effect of Panax notoginseng Mixture on Hepatic Ischemia/Reperfusion Injury in mice via regulating NR3C2, SRC and GAPDH. Frontiers in Pharmacology, 2021, 12:756259.

Sai Zhang, Zhenglu Wang, Shunli Fan, Tao Liu, Sei Yoshida, Shuang Yang, Lei Liu, Wen Hou, Lei Cao, Jianxi Wang, Zhuolun Song, Shanni Li, Sirui Zhang, Hao Wang, Jianghong Li, Hong Zheng^*, Zhongyang Shen^*. Capecitabine can induce T cell apoptosis: A potential immunosuppressive agent with anti-cancer effect. Frontiers in Immunology, 2021, Sep 7; 12:737849

Wen Hou, Xiaoli Wu^*. Diverse functions of  T cells in the progression of hepatitis B virus and hepatitis C virus infection. Frontiers in Immunology, 2021, 11:619872.

Lin Cai, Wen Hou^*.Specific disulfide bond formation directed by peptide nucleic acids. Journal of the Brazilian Chemical Society, 2020, 31(5), 982-989.

1. Sihua Liu, Hongyun Liu, Jun Kang, Leling Xu, Keke Zhang, Xueping Li, Wen Hou, Zhiyun Wang^*, Tao Wang^*.The SFTSV NSs protein interacts with CDK1 to induce G2 cell cycle arrest and positively regulate viral replication. Journal of Virology, 2020, 94(6), e01575-19.

2. Han Yang^#, Hongsheng Liu^#, Wen Hou, Junxiao Gao, Yue Duan, Daohe Wei, Xiaoqun Gong, Hanjie Wang, Xiaoli Wu^*, Jin Chang^*. NIR-Responsive Mesoporous Silica Nanosystem for Synergetic Photothermal-immunoenhancement Therapy of Hepatocellular Carcinoma. Journal of Materials Chemistry B, 2020, 8(2):251-259.

五、联系方式

houwen@nankai.edu.cn