姓名：李凤娥

职称：副主任医师

导师类型：硕士研究生导师 

一、教育和国外访学经历

2005.09-2010.07，山东省济宁医学院，临床医学，学士

2010.08-2015.07，天津医科大学，肿瘤学，博士（硕博连读）

2013.08-2014.10，美国MD安德森癌症研究中心，Melanoma Oncology，国家公派留学联合培养博士

二、工作经历

2015.07-2018.03， 天津市第一中心医院，妇科，住院医师

2015.10-2017.02，天津医科大学第二附属医院，规范化培训，住院医师2017.02-2020.01，美国贝勒医学院，Huffington center，博士后

2020.01-2021.10， 美国MD安德森癌症研究中心，Melanoma Oncology，博士后

2021.10-2025.04， 天津市北辰医院，肿瘤科副主任医师，中心实验室负责人

2025.06-至今，   天津市人民医院，肿瘤5科，副主任医师

三、研究方向和科研课题

研究方向

肿瘤免疫基础研究

TIL基础和临床转化研究

肿瘤新抗原疫苗及临床转化研究

个体化多肽疫苗 

TCR 克隆

TCR-T

肿瘤新靶点治疗药物研发（细胞信号通路研究）

承担的科研课题

基础研究课题

天津市北辰区科技发展计划项目  SHGY-2021006  肿瘤浸润性淋巴细胞（TIL）与肿瘤发生发展以及患者预后的相关性研究, 5万, 2021.12-2024.12, 主要负责人 结题

天津市自然科学基金自主立项面上项目，题目：非小细胞肺癌中SENP 3介导YTHDF类泛素化修饰对其蛋白相分离和耐药性产生中的机制研究，主持，10万，在研

国家自然科学基金（81471761）：冷冻消融联合TGF-β阻断治疗前列腺癌的有效性及相关机制研究，2015.01-2018.12，结题，第六参与人

国家自然科学基金（81501568）：新型调节细胞因子 IL-35 在前列腺癌发生发展和冷冻免疫中的作用及相关机制研究，2016/01-2018/12，结题，第二负责人

主研临床试验项目

LM303注射液治疗晚期实体肿瘤的研究者发起的临床研究，拟55万元，2025.07-2027.07, Sub-PI，在研

LM103注射液治疗晚期实体肿瘤的研究者发起的临床研究，88.8万, 2022.5-2023.6，主要研究者，结题

水疱性口炎溶瘤病毒注射液（Revottack）用于广泛期小细胞肺癌患者静脉给药的临床探索研究，51.5万元，2022.7.18-2023.12.31, 主要研究者，结题

一项评价自体肿瘤浸润性淋巴细胞（TILs）LM103注射液联合PD-1在晚期实体瘤患者中安全性、耐受性、免疫反应和初步疗效的探索性临床研究，65.9万元，2023.10.8-2026.10.8, 主要研究者，结题

LM303注射液治疗晚期实体肿瘤的研究者发起的临床研究，66万元，2023.10.8-2026.10.8, 主要研究者，结题

一项评价自体肿瘤浸润性淋巴细胞（TILs）LM103注射液在晚期实体瘤患者中安全性、耐受性、免疫反应和初步疗效的探索性临床研究，65.9万元，2023.5.18-2026.5.17, 主要研究者，结题

HR070803联合奥沙利铂、5-氟尿嘧啶、亚叶酸钙对比白蛋白紫杉醇联合吉西他滨一线治疗晚期胰腺癌的开放、随机、多中心III期临床研究，2023.5-2024.12，27.3万元，主要研究者，结题

四、学术兼职

国际冷冻消融协会委员

国际肿瘤介入和临床转化医学联盟发起人

中国抗癌协会肿瘤介入学专委会化疗与免疫学治疗专家委员会副主委

天津市整合医学学会肿瘤微创诊疗专业委员会委员

天津市中西医结合学会专业委员会委员

天津市整合医学学会肝转移瘤诊疗专业委员

五、审稿编辑
Section Editor （2020-至今）

Archives of Medical Science

客座编辑（2014-2015）

Gene Regulation and Systems Biology

审稿期刊
Journal of Hematology and Oncology Research
Journal of Biological Methods
Clinical Genetics
Molecular and Cellular Biochemistry
Molecular Medicine Reports
Oncology Reports
Archives of Medical Science
Stem Cell International
Oncology Letters
International Journal of Oncology
Oncotarget

Frontiers in medicine

六、近五年发表的学术论文 

Fenge Li, Yupeng Wang, Mengli Jin, Hongli Li, Jin Yan, Jiandong Hu, Xianfeng Zhang, Chunwa Wu, Luqing Wei. A comprehensive analysis of immune characteristic and clinical prognosis in Asian patients with SARS-CoV-2/COVID-19 of strain omicron sub-variants XBB infection: a retrospective study of 450 cases. (Archives journal of medicine, accepted，in press)

Huancheng Wu, Mengli Jin, Jiandong Hu, Fenge Li (corresponding author). Nicotinamide Adenine Dinucleotide alleviates neuroinflammation in rats with traumatic brain injury （Neuroscience letters，accepted, in press）

Jiandong Hu, Mengli Jin, Weihong Feng, Barbara Nassif-Rausseo, Alexandre Reuben , Chunhua Ma, Gregory Lizee, Fenge Li(corresponding author). Clinical and Fundamental Research Progressions on Tumor-Infiltrating Lymphocytes Therapy in Cancer. Vacines (Basel), 2025 May 14;13(5):521.

Xiaolin Li, Jiandong Hu, Fenge Li (corresponding author). Hysteroscopy combined with laparoscopy in the diagnosis and treatment of omentum majus incarceration secondary to uterine perforation: a case report and review of literature .The Journal of Obstetrics and Gynaecology Research. 2025;51:e16213.

Fenge Li, Chong Tian, Yupeng Wang, Huancheng Wu, Mengli Jin, Xueming Du, Jin Yan, Haipeng Yu. Prognostic and predictive significance of peripheral and tumor-infiltrating lymphocytes in newly diagnosed stage III/IV none-small-cell Lung cancer. Frontiers in medicine，2024,11:1349178

Fenge Li, Yupeng Wang, Jin Yan, Xiaolin Li, Huancheng Wu, Chong Tian, Xueming Du, Weihong Feng, Xiaoqing Zhang, Yongming Xue, Yongjin Hu, Jianhui Wei, Huaqing Wang, Wenxin Liu. Autologous tumor-infiltrating lymphocyte mono-therapy rapidly shrank tumor in an Asian patient of metastatic cervical cancer with severe myelosuppression: two cases report. International journal of women's health, 2024:16；31-39

Hongli Li, Luqing Wei, Fenge Li（Co-corresponding Author).Diagnose of mycobacterium avium complex infection utilizing metagenomics next-generation sequencing: a case report. Front. Med. 10:1247034. doi: 10.3389/fmed. 2023.1247034

Fenge Li, Huancheng Wu , Xueming Du , Yimo Sun , Barbara Nassif Rausseo , Amjad Talukder , Arjun Katailiha , Lama Elzohary , Yupeng Wang , Zhiyu Wang, and Gregory Lizee. Epidermal Growth Factor Receptor-Targeted Neoantigen Peptide Vaccination for the Treatment of Non-Small Cell Lung Cancer and Glioblastoma. Vaccines, 2023,11,1460.

Fenge Li, Yimo Sun, Heather Sonnemann, Kyle R. Jackson, Amjad H. Talukder, Arjun S. Katailiha, Gregory Lizee. Evolution of CD8+ T Cell Receptor (TCR) Engineered Therapies for the Treatment of Cancer. Cells. 2021 Sep; 10(9): 2379.

Fenge Li, Ligang Deng, Amjad H. Talukder, Kyle R. Jackson, Arjun Katailiha, Sherille D. Bradley, Heather Sonnemann, Qingwei Zou, Caixia Chen, Chong Huo,Yulun Chiu1, Matthew Stair, Weihong Feng, Aleksander Bagaev, Nikita Kotlov, Viktor Svekolkin, Ravshan Ataullakhanov, Natalia Miheecheva, Felix Frenkel, Yaling Wang, Minying Zhang, David Hawke, Jason Roszik, Ling Han, Shuo Zhou, Yan Zhang, Zhenglu Wang, Patrick Hwu, Xueming Du, and Gregory Lizée. Neoantigen vaccination induces clinical and immunologic responses in non-small cell lung cancer patients harboring EGFR mutations. J Immunother Cancer 2021;9:e002531

Ravi G. Gupta, Fenge Li, Jason Roszik, Gregory Lizee. Exploiting tumor Neoantigens to target cancer evolution: current challenges and promising therapeutic approaches. Cancer Discovery, 2021; 11: 1-16. DOI:10.1158/2159-8290.CD-20-1575

Fenge Li, Liping Wang, Yixiang Zhang, Weihong Feng, Tao Ju, Zaiping Liu, Zhenglu Wang, Xueming Du. A retrospective study on using a novel single needle cone puncture approach for the Iodine-125 seed brachytherapy in treating patients with thoracic malignancy. Frontiers in Oncology, 2021; 11: 640131. doi: 10.3389/fonc.2021.640131

Sherille D. Bradley, Amjad Talukder, Ivy Lai, Rebecca Davis, Hector Alvarez, Herve Tiriac, Minying Zhang, Yulun Chiu, Brenda Melendez, Kyle Jackson, Arjun Katailiha, Heather Sonnemann, Fenge Li, Yaan Kang, Na Qiao, Bih-Fang Pan, Philip L. Lorenzi, Mark Hurd, Elizabeth Mittendorf, Christine B. Peterson, Milind Javle, Christopher Bristow, Michael Kim, David Tuveson, David Hawke, Robert Wolff, Patrick Hwu, Anirban Maitra, Jason Roszik, Cassian Yee and Gregory Lizée. VESTIGIAL-LIKE 1 IS A SHARED TARGETABLE CANCER-PLACENTA ANTIGEN EXPRESSED BY PANCREATIC AND BASAL-LIKE BREAST CANCERS. Nat Commun. 2020; 11: 5332.

Courtney A. Burger, Danye Jiang, Fenge Li, Melanie A. Samuel. C1q Regulates Horizontal Cell Neurite Confinement in the Outer Retina. Front Neural Circuits. 2020; 14: 583391.

Qizhen Cao, Min Zhou, Wanqin Wang, Sixiang Shi, Jun Zhao, Ku Geng, Qian Huang, Xiaoxia Wen, Fenge Li, Hiroto Hatakeyama, Chunyu Xu, David Piwnica-Worms, Weiyi Peng, Dapeng Zhou, Anil K. Sood, Chun Li. Induction of Anti-tumor Immunity in Mice by the Combination of Nanoparticle-Based Photothermolysis and Anti-PD-1 Checkpoint Inhibition. Nanomedicine .2020 Apr;25:102169.

Xiaolin L, Fenge L, Yumei Z, Jing L, Zhonge T and Quanxin Q. Advanced pelvic malignancy causes syndrome of inappropriate antidiuretic hormone secretion: a case report. J Gynecol Oncol , Volume 3, Issue 3, 1034.

Yan Lan, Shuo Zhou, Weihong Feng, Ying Qiao , Xueming Du , Fenge Li (Co-corresponding author). Association of tumor mutation burden and EGFR inhibitor history with survival in patients with metastatic stage III/IV non-small cell Lung Cancer. CLINICS (Sao Paulo) 2021; 76: e2251.

七、荣誉和奖励

2013.8-2014.10 中国国家留学基金委奖学金（CSC）
2008.10       国家励志奖学金

八、联系方式

通讯地址：天津市红桥区芥园西道190号

办公室电话022-27557552

E-mai：rosetea85@163.com